eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
197
204
44692
Review Article
Recent findings in production and health benefits of prebiotics; a review of literatures
Abdorrasoul Malekpour
immurasoul@gmail.com
1
Mehdi Forouzesh
mehdiforouzesh@gmail.com
2
Saeid Gholamzadeh
saeedghmail@yahoo.com
3
Younes Ghasemi
ghasemiy@sums.ac.ir
4
Mohammad Moaddeli
ms.moaddeli@yahoo.com
5
Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran
M.D., Assistant Professor, Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran
Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Prebiotics are known as fermented ingredient with specific health benefits. The two main fermentative substrates of dietary origin are non-digestible carbohydrates and proteins which escape digestion in the small intestine. Beside traditional protocols for production of prebiotics, there are some commercial advanced methods for mass production of prebiotics with acceptable health effects. On the other hand, different types of nondigestible oligosaccharides (NDO) are used in the food and drug industries as functional foods and nutraceuticals due to their prebiotic effects and also immunomodulation effects (ex. SCFA modulate chemokine expression in intestinal epithelial cells). Prebiotics with novel and wide variety of health benefits deal with a bright future for improving society health.
https://tips.sums.ac.ir/article_44692_cf98d2b1552fe1ef0d9725dd295f3b2a.pdf
Prebiotics
production
Health Benefits
eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
205
218
42266
Research(Original) Article
QSAR analysis of some azole derivatives as potent aromatase inhibitors
Razeih Sabet
1
Soghra Khabnadideh
khabns@sums.ac.ir
2
Samaneh Mohseni
3
Ayyub Mojaddami
mojaddamia@sums.ac.ir
4
Zahra Rezaei
rezaeiza@sums.ac.ir
5
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
A high proportion of breast tumors are hormone-dependent, implying that endogenous estrogens play a critical role in cancer cell proliferation. One of the most effective strategies for the treatment of breast cancer is reduction of estrogens level by inhibiting aromatase enzyme which is responsible for catalyzing the rate-limiting step in estrogen biosynthesis. A series of azole derivatives as potential aromatase inhibitors were subjected to two different drug design methodologies, QSAR and molecular docking simulation. MLR, FA-MLR, PCR and GA-PLS were employed to make connections between the structural parameters and aromatase inhibitory activity. GA-PLS represented superior results and a model with a high statistical quality (R2 = 0.86 and Q2 = 0.83) for predicting the inhibitory activity. The results can provide useful information for the development of more potent aromatase inhibitors.
https://tips.sums.ac.ir/article_42266_386f2aa39f171cda0865e50ca004c573.pdf
QSAR
Aromatase inhibitor
Azole derivatives
eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
219
224
44693
Research(Original) Article
Antimicrobial effect of some herbal medicine against infectious bacteria isolated from burn wound
Shahin Mohammadsadeghi
shmohammadsadeghi@yahoo.com
1
Hasan Habibi
dr.h.habibi@gmail.com
2
Abdolkhalegh Keshavarzi
iliakeshavarzi@yahoo.com
3
Abdorrasoul Malekpour
immurasoul@gmail.com
4
Plastic Surgery Ward, School of Medicine, Shahid Beheshti University of Medical Sciences
Agricultural and Natural Resources College, Persian Gulf University, Bushehr, Iran
Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran
Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran
Herbal compounds with antimicrobial effects are of major considerations because of increasing antimicrobial resistance of pathogenic bacteria. In this study, we investigated the antimicrobial effects of Melissa officinalis L, Plantago major L, Orobancha crenata Forsk, Phoenix dactylifera, Ziziphus mauritiana and Teucrium Polium seed extracts on some human pathogenic bacteria isolated from burn wounds. Disk-diffusion antibiotic sensitivity testing, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were applied to assess the antibacterial activity of the extracts in comparison to the tetracycline, as a control antibiotic. The extract of the Orobancha crenata showed stonger antibacterial effects than the other herbal extracts on Pseudomonas aeroginosa and Kelebsiela ponomoni. Staphylococcus aureus was the most sensitive one to the Ziziphus mauritiana nucleus extract compared to other herbs. According to the results of this study, it can be concluded that extracts of some native plants of Iran can be appropriate alternative to the existing antibiotics, applicable for prevention of burn infections.
https://tips.sums.ac.ir/article_44693_56ccaa3771e4f1aea9be1b6958788a40.pdf
Melissa officinalis
Teucrium Polium
Burn infections
pathogenic bacteria
eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
225
234
44719
Research(Original) Article
Volatile Constituents and Antioxidant Activity of Spathes from Five Uncommon Varieties of Phoenix dactylifera L.
Mohammad Ali Farbodniaye Jahromi
mfarboodnia@gmail.com
1
Mahmood Reza Moien
2
Motahare Mollaei
3
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
This study deals with characterization of chemical composition of spathe essential oil of five male varieties of Phoenix dactylifera L. including Ghir (GHI), Lar (LAR), Khosooyeh (KHO), Boyer (BOY) and Shahani (SHA). The essential oil samples were prepared through hydro-distillation using a Clevenger type apparatus. Analysis of oil samples was carried out following dehydration process. Hexane diluted samples were injected into a Gas chromatograph attached to a Mass spectrometer (GC/MS). Kovats indices (KI) was calculated for each compound and their mass fragmentation pattern were studied. The results compared with the relevant information procured from Wiley nl7 library and the Pherobase and NIST databases. Results of quantitative analysis of oil specimens indicated that, Ghir (0.03%) and Lar (0.07%) cultivars contain the lowest and the highest extraction yield of essential oil respectively. The oil samples were further screened for their DPPH free radical scavenging effects by means of a thin layer chromatographic method which showed a positive indication of anti DPPH activity through the visualization of spots and a yellow colour change on spraying the chromatoplates with a 0.2 % methanolic solution of DPPH. Results also indicated that 3,4-dimethoxytoluene is the main component in all Phoenix dactylifera L. spathe oil samples. This methoxylated aromatic compound showed the highest cocentration in Boyer (62.45%) and the lowest proportion in Khosooyeh cultivar (41.57%). Boyer spathe oil was superior in manifestation of DPPH free radical scavenging activity as compared with other cultivars.
https://tips.sums.ac.ir/article_44719_c04e865abfacf137e63a02e0a3067e21.pdf
eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
235
240
44721
Research(Original) Article
Toxicity of Hexyl Acrylate Modified PAMAM Dendrimer
Mohammad Ashkan Naderian
a.naderian@yahoo.com
1
Amin Reza Akbarizadeh
akbarizadehar@yahoo.com
2
Akram Jamshidzadeh
ajamshid@sums.ac.ir
3
Ali Dehshahri
dehshahria@sums.ac.ir
4
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
The aim of this study was to evaluate the effect of the hexyl acrylate conjugated polyamidoamine (PAMSM) dendrimer on different cell lines in the presence and absence of serum. Although the positively charged dendrimers including PAMAM has been considered as efficient gene carriers, their cytotoxicity is a major barrier for their clinical applications. The conjugation of hexyl acrylate on PAMAM dendrimer was carried out to improve the hydrophilic-hydrophiobic balance of the dendrimer as well as the modulation of the positive charge on the dendrimer structure. The cytotoxicity of PAMAM derivatives was evaluated using MTT test on HepG2, MCF-7 and A549 cell lines in the presence and absence of serum. The results revealed that the modified PAMAM dendrimers induced less toxic effects on the cell lines in the presence of serum. Therefore, conjugation of acrylate on the PAMAM structure could be an efficient way to reduce the dendrimer toxicity allowing the administration of more dendrimer for gene delivery.
https://tips.sums.ac.ir/article_44721_ab27903795e02ab5ed2a05b6d7d72136.pdf
eng
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
2018-12-01
4
4
241
248
10.30476/tips.2018.44720
44720
Research(Original) Article
A retrospective and cross-sectional study to evaluate potential drug – drug interaction in hospitalized pediatrics, Bandar Abbas, Iran
Motahareh Ahmadi
motahare.ahmadi66@gmail.com
1
Abd Nazemi
dr_amnazemi@yahoo.com
2
Seyedeh Fatemeh Davoodpour
dr.davoodpour@yahoo.com
3
Fahimeh Gharaie Pour
fahimehgharayi89@yahoo.com
4
Maryam Montaseri
maryam.montaseri@hums.ac.ir
5
Omid Safa
odsafa@yahoo.com
6
Hormozgan University of Medical Sciences
Hormozgan University of Medical Sciences
Hormozgan University of Medical Sciences
Hormozgan University of Medical Sciences
Hormozgan University of Medical Sciences
Hormozgan University of Medical Sciences
AbstractBackground: The incidence of drug interactions in hospitalized patients due to the administration of various drugs, the lack of proper monitoring and sometimes multiple patient’s co-morbidities, is common. This study aims to evaluate potential drug-drug interactions (PDDIs) in pediatrics hospitalized in an educational pediatric hospital. Methods: The present study is a retrospective cross-sectional study. The study population included patients hospitalized in different parts of Bandar Abbas pediatrics hospital. A total of 400 medical records were assessed. PDDIs were evaluated by Lexi-Comp drug interaction and SPSS software was used for data analysis.Result: Based on our results PDDIs were observed in 133 cases (33.25%). The mean ± SD of PDDIs per prescription was 1.97 ± 1.56. The majority of the interaction were moderate (79.1%) with risk rating C (45.7%). Salbutamol, phenytoin, phenobarbital and clarithromycin were responsible for the most interactions with 95, 40, 25,17 of PDDIs, respectively. Drug interactions with risk-rating X, observed in 5 cases. Number of drugs per prescription was significantly associated with PDDIs (P= 0.000)Conclusion: Although the prevalence rate of PDDIs in this study was lower than reported by recent studies, but careful evaluation of drug charts and implantation of educational programs for medical staff, should be considered. Abbreviation PDDIs: Potential Drug-Drug InteractionsDDIs: Drug-Drug InteractionsED: Emergency departmentNICU: Neonatal Intensive Care UnitPICU: Pediatric Intensive Care Unit
https://tips.sums.ac.ir/article_44720_08399f5ca845670f8190238884d49a7c.pdf