ORIGINAL_ARTICLE
Central serous chorioretinopathy following use of desmopressin nasal spray: A case report
In the present report, we describe a middle- age man who experienced decrased visual acuity and metamorphopsia several times since administration of desmpressin nasal spray.Ophthalmologic examination revealed that visual acuity of OD: 4/10 and OS: 9/10 with correction. pigmentary change and retinal elevation was present in fundus examination. Finding was documented with optical coherence tomography (OCT) and Fluorescein angiography (FA).The patient was diagnosed as central serous chorioretinopathy (CSCR) due to consumption of desmopressin nasal spray.We conclude that desmopressin might be developed of CSCR but more study is recommended to confirm this hypothesis that there is association between this kind of drug and development of CSCR.
https://tips.sums.ac.ir/article_42254_6e2d24d2f13b944c5790acde7eb4f057.pdf
2018-06-01
Vahid
Beigi
v.beigi66@gmail.com
1
LEAD_AUTHOR
Mehrnoosh
Maalhagh
2
AUTHOR
Mohammad sadegh
Beigi
3
AUTHOR
Meisam
Ghanbari
4
AUTHOR
Kisma N, Loukianou E, Pal B. Central Serous Chorioretinopathy Associated with Desmopressin Nasal Spray: Causality or Unfortunate Association. Case Reports in Ophthalmology. 2018;9(1):126-31.
1
Bouzas EA, Scott MH, Mastorakos G, Chrousos GP, Kaiser-Kupfer MI. Central serous chorioretinopathy in endogenous hypercortisolism. Archives of ophthalmology (Chicago, Ill : 1960). 1993;111(9):1229-33.
2
Carnahan MC, Goldstein DA. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol. 2000;11(6):478-83.
3
Chaine G, Haouat M, Menard-Molcard C, Favard C, Vignal-Clermont C, Campinchi-Tardy F, et al. [Central serous chorioretinopathy and systemic steroid therapy]. Journal francais d'ophtalmologie. 2001;24(2):139-46.
4
Fawzi AA, Cunningham ET, Jr. Central serous chorioretinopathy after bone marrow transplantation. Am J Ophthalmol. 2001;131(6):804-5.
5
Abu el-Asrar AM. Central serous chorioretinopathy complicating systemic corticosteroid therapy. European journal of ophthalmology. 1997;7(3):297-300.
6
Chumbley LC, Frank RN. Central serous retinopathy and pregnancy. Am J Ophthalmol. 1974;77(2):158-60.
7
Gelber GS, Schatz H. Loss of vision due to central serous chorioretinopathy following psychological stress. The American journal of psychiatry. 1987;144(1):46-50.
8
Williams RB, Jr., Lane JD, Kuhn CM, Melosh W, White AD, Schanberg SM. Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks. Science (New York, NY). 1982;218(4571):483-5.
9
Boucher MC, el Toukhy EA, Cormier G. Bilateral serous retinal detachments associated with Goodpasture's syndrome. Canadian journal of ophthalmology Journal canadien d'ophtalmologie. 1998;33(1):46-9.
10
Dinakaran S, Desai SP. Central serous retinopathy associated with Weber-Christian disease. European journal of ophthalmology. 1999;9(2):139-41.
11
Malerbi DA, Mendonca BB, Liberman B, Toledo SP, Corradini MC, Cunha-Neto MB, et al. The desmopressin stimulation test in the differential diagnosis of Cushing's syndrome. Clinical endocrinology. 1993;38(5):463-72.
12
ORIGINAL_ARTICLE
Acute onset bilateral myopia induced by Chlordiazepoxide
Oral drugs may have adverse effects that affect vision. There are some drugs that are confirmed to induce ciliary effusion such as topiramate. Here we present a case of sudden onset decreased vision after consumption of chlordiazepoxide for a while.
https://tips.sums.ac.ir/article_42255_5ebe758a0d015f7049ff07a36ce1a4a4.pdf
2018-06-01
Adel
Hamid
1
AUTHOR
Mehrnoosh
Maalhagh
2
AUTHOR
Meisam
Ghanbari
3
AUTHOR
Vahid
Beigi
v.beigi66@gmail.com
4
1- Department of ophthalmology, Poostchi ophthalmology research center, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Antidiabetic, Antioxidant, Antibacterial, and Antifungal Activities of Vanadyl Schiff Base Complexes
This review comprises some biological activities of vanadyl Schiff base complexes in terms of antidiabetic, antioxidant, antibacterial and anti-fungal activity. The structure activity relationship for the potential biological activities of these compounds is also discussed.
https://tips.sums.ac.ir/article_42252_1388f22f657e0235d6536a25118daf38.pdf
2018-06-01
Susan
Torabi
torabi_s@sums.ac.ir
1
LEAD_AUTHOR
Mohsen
Mohammadi
2
AUTHOR
Marzieh
Shirvani
3
AUTHOR
ORIGINAL_ARTICLE
Analysis of Fatty Acid Composition of Crude Seed Oil of Lactuca sativa L. by GC-MS and GC Methods
Lactuca sativa L. (Garden Lettuce), is an edible herb cultivated in Iran and other parts of the world. In Traditional Iranian Pharmacy books, garden lettuce is named "Kass Bostani" and Hakim Aqili classified it as a "Ghazā'ye Dawā'ee" (Ghazā means Food; Dawā means Drug). It is said to be soporific, prescribed to cure insomnia and to be useful in thirst and feeling of hotness and burning in the stomach. Seeds of this herb reduce semen, suppress libido and are useful in cases of frequent nocturnal emissions. Fixed oil obtained from seeds of this plant is reputed to have hypnotic and brain moistening properties. In this study we aimed to analyze the fatty acid composition of the crude seed oil of Lactuca sativa L. Methyl esterification of the fatty acids was performed by the method of Ken'ichi Ichihara et al but with a slight modification. Components of the oil were then extracted by n-hexane and analyzed by Gas chromatography-Mass spectroscopy and Gas Chromatography methods. Identified constituents which represented 98.20% of the total elutes were the methyl esters of linoleic (52.38%), oleic (34.42%), palmitic (7.25%), stearic (2.66%), arachidic (1.32%) and myristic (0.17%) acids. Total percentages of methyl esters of the saturated and unsaturated fatty acids identified in our examined oil are 11.4 and 86.80% respectively. In conclusion, seed fat of Lactuca sativa L. like many other plant fats, is rich in unsaturated fatty acids.
https://tips.sums.ac.ir/article_42253_3ebce8113090e1290b86162f1bbc0e0d.pdf
2018-06-01
Suleiman
Afsharypuor
afsharypuor@pharm.mui.ac.ir
1
LEAD_AUTHOR
Mahdieh
Ranjbar
m_ranjbar@dr.com
2
AUTHOR
Mohammad
Mazaheri
mazaherimohammad@yahoo.com
3
AUTHOR
Fereshteh
Shakibaei
shakibaei@med.mui.ac.ir
4
AUTHOR
Abolfazl
Aslani
aslani@pharm.mui.ac.ir
5
AUTHOR
ORIGINAL_ARTICLE
Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation
The cholestatic liver disease ensues with a hepatic accumulation of cytotoxic molecules. Several hydrophobic bile acids are known as cytotoxic agents accumulated in the liver during cholestasis. Chenodeoxycholic acid (CDCA) is a toxic hydrophobic bile acid. Oxidative stress and mitochondrial dysfunction are well-known mechanisms of bile acids cytotoxicity. In the current study, CDCA effect on isolated liver mitochondria was monitored by analyzing the changes in mitochondrial dehydrogenases activity, mitochondrial permeabilization, and mitochondrial membrane potential. On the other hand, taurine (1 mM) and carnosine (1 mM) were added as potential protective agents against CDCA-induced mitochondrial dysfunction. Increasing concentrations of CDCA (100 µM - 1000 µM) impaired mitochondrial membrane potential, decreased mitochondrial dehydrogenases activity and enhanced mitochondrial permeabilization and swelling. It was found that taurine and carnosine supplementation preserved mitochondrial function in the presence of CDCA. The results mention that toxicologically relevant concentrations of CDCA impaired mitochondrial function. On the other hand, taurine and carnosine might be applicable as protective agents against bile acids-induced mitochondrial impairment and toxicity.
https://tips.sums.ac.ir/article_42256_850076220796c1701ba058ab19a155c6.pdf
2018-06-01
Reza
Heidari
rezaheidari@hotmail.com
1
Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
AUTHOR
Narges
Abdoli
2
AUTHOR
Mohammad Mehdi
Ommati
3
AUTHOR
Akram
Jamshidzadeh
ajamshid@sums.ac.ir
4
AUTHOR
Hossein
Niknahad
niknahadh@sums.ac.ir
5
LEAD_AUTHOR
Lefkowitch J. 6 Cholestasis. Liver Pathology. 2011;4;89.
1
Gossard AA, Talwalkar JA. Cholestatic liver disease. The Medical clinics of North America. 2014;98;73-85.
2
Patil A, Mayo MJ. Complications of Cholestasis. In: Md KDL, Md JAT, editors. Cholestatic Liver Disease. Clinical Gastroenterology: Humana Press; 2008. p. 155-169.
3
Perez MJ, Briz O. Bile-acid-induced cell injury and protection. W J Gastroenterol. 2009;15;1677-1689.
4
Martinez-Diez MC, Serrano MA, Monte MJ, Marin JJG. Comparison of the effects of bile acids on cell viability and DNA synthesis by rat hepatocytes in primary culture. Biochim Biophys Acta. 2000;1500;153-160.
5
Heidari R, Niknahad H, Sadeghi A, Mohammadi H, Ghanbarinejad V, Ommati MM, Hosseini A, Azarpira N, Khodaei F, Farshad O, Rashidi E, Siavashpour A, Najibi A, Ahmadi A, Jamshidzadeh A. Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury. Biomed Pharmacother. 2018;103;75-86.
6
Heidari R, Moezi L, Asadi B, Ommati MM, Azarpira N. Hepatoprotective effect of boldine in a bile duct ligated rat model of cholestasis/cirrhosis. PharmaNutrition. 2017;5;109-117.
7
Heidari R, Ghanbarinejad V, Mohammadi H, Ahmadi A, Esfandiari A, Azarpira N, Niknahad H. Dithiothreitol supplementation mitigates hepatic and renal injury in bile duct ligated mice: Potential application in the treatment of cholestasis-associated complications. Biomed Pharmacother. 2018;99;1022-1032.
8
Heidari R, Ghanbarinejad V, Mohammadi H, Ahmadi A, Ommati MM, Abdoli N, Aghaei F, Esfandiari A, Azarpira N, Niknahad H. Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. Biomed Pharmacother. 2018;97;1086-1095.
9
Bomzon A, Holt S, Moore K. Bile acids, oxidative stress, and renal function in biliary obstruction. Semin Nephrol. 1997;17;549-562.
10
Chen C-C, Ho C-Y, Chaung H-C, Tain Y-L, Hsieh C-S, Kuo F-Y, Yang C-Y, Huang L-T. Fish omega-3 fatty acids induce liver fibrosis in the treatment of bile duct-ligated rats. Dig Dis Sci. 2013;58;440-447.
11
Copple BL, Jaeschke H, Klaassen CD. Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis. 2010;30;195-204.
12
Holt S, Marley R, Fernando B, Harry D, Anand R, Goodier D, Moore K. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Kidney Int. 1999;55;271-277.
13
Rolo AP, Oliveira PJ, Moreno AJM, Palmeira CM. Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. Toxicol Sci. 2000;57;177-185.
14
Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J Clin Invest. 1993;92;17-24.
15
Schulz S, Schmitt S, Wimmer R, Aichler M, Eisenhofer S, Lichtmannegger J, Eberhagen C, Artmann R, Tookos F, Walch A, Krappmann D, Brenner C, Rust C, Zischka H. Progressive stages of mitochondrial destruction caused by cell toxic bile salts. Biochim Biophys Acta. 2013;1828;2121-2133.
16
Arduini A, Serviddio G, Tormos AM, Monsalve M, Sastre J. Mitochondrial dysfunction in cholestatic liver diseases. Front Biosci. 2012;4;2233-2252.
17
Rolo AP, Palmeira CM, Wallace KB. Mitochondrially mediated synergistic cell killing by bile acids. Biochim Biophys Acta. 2003;1637;127-132.
18
Palmeira CM, Rolo AP. Mitochondrially-mediated toxicity of bile acids. Toxicology. 2004;203;1-15.
19
Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72;101-163.
20
Huxtable RJ, Michalk D. Taurine in Health and Disease: Springer Science & Business Media; 2013 2013/11/21/. 447 p.
21
Timbrell JA, Seabra V, Waterfield CJ. The in vivo and in vitro protective properties of taurine. General Pharmacol. 1995;26;453-462.
22
Heidari R, Jamshidzadeh A, Ghanbarinejad V, Ommati MM, Niknahad H. Taurine supplementation abates cirrhosis-associated locomotor dysfunction. Clin Exp Hepatol. 2018;4;72-82.
23
Niknahad H, Jamshidzadeh A, Heidari R, Zarei M, Ommati MM. Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment. Clin Exp Hepatol. 2017;3;141-151.
24
Jamshidzadeh A, Abdoli N, Niknahad H, Azarpira N, Mardani E, Mousavi S, Abasvali M, Heidari R. taurine alleviates brain tissue markers of oxidative stress in a rat model of hepatic encephalopathy. Trend Pharm Sci. 2017;3;181-192.
25
Jamshidzadeh A, Heidari R, Abasvali M, Zarei M, Ommati MM, Abdoli N, Khodaei F, Yeganeh Y, Jafari F, Zarei A, Latifpour Z, Mardani E, Azarpira N, Asadi B, Najibi A. Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia. Biomed Pharmacother. 2017;86;514-520.
26
Heidari R, Jamshidzadeh A, Niknahad H, Safari F, Azizi H, Abdoli N, Ommati MM, Khodaei F, Saeedi A, Najibi A. The hepatoprotection provided by taurine and glycine against antineoplastic drugs induced liver injury in an ex vivo model of normothermic recirculating isolated perfused rat liver. Trend Pharm Sci. 2016;2;59-76.
27
Heidari R, Jamshidzadeh A, Niknahad H, Mardani E, Ommati MM, Azarpira N, Khodaei F, Zarei A, Ayarzadeh M, Mousavi S, Abdoli N, Yeganeh BS, Saeedi A, Najibi A. Effect of taurine on chronic and acute liver injury: Focus on blood and brain ammonia. Toxicol Report. 2016;3;870-879.
28
Heidari R, Rasti M, Shirazi Yeganeh B, Niknahad H, Saeedi A, Najibi A. Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine. BioImpacts. 2016;6;3-8.
29
Heidari R, Sadeghi N, Azarpira N, Niknahad H. Sulfasalazine-induced hepatic injury in an ex vivo model of isolated perfused rat liver and the protective role of taurine. Pharm Sci. 2015;21;211-219.
30
Heidari R, Jamshidzadeh A, Keshavarz N, Azarpira N. Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice. Sci Pharm. 2015;83;143-158.
31
Heidari R, Babaei H, Eghbal MA. Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine. Res Pharm Sci. 2014;9;97-105.
32
Heidari R, Babaei H, Eghbal MA. Cytoprotective Effects of Taurine Against Toxicity Induced by Isoniazid and Hydrazine in Isolated Rat Hepatocytes. Arch Industl Hyg Toxicol. 2013;64;201-210.
33
Hansen SH, Andersen ML, Cornett C, Gradinaru R, Grunnet N. A role for taurine in mitochondrial function. J Biomed Sci. 2010;17;1-8.
34
Hansen SH, Grunnet N. Taurine, Glutathione and Bioenergetics. In: Idrissi AE, L'Amoreaux WJ, editors. Taurine 8. Advances in Experimental Medicine and Biology: Springer New York; 2013. p. 3-12.
35
Ahmadian E, Babaei H, Mohajjel Nayebi A, Eftekhari A, Eghbal MA. Venlafaxine-induced cytotoxicity towards isolated rat hepatocytes involves oxidative stress and mitochondrial/lysosomal dysfunction. Adv Pharm Bull. 2016;6;521-530.
36
Parvez S, Tabassum H, Banerjee BD, Raisuddin S. Taurine Prevents Tamoxifen-Induced Mitochondrial Oxidative Damage in Mice. Basic Clin Pharmacol Toxicol. 2008;102;382-387.
37
Xu S, He M, Zhong M, Li L, Lu Y, Zhang Y, Zhang L, Yu Z, Zhou Z. The neuroprotective effects of taurine against nickel by reducing oxidative stress and maintaining mitochondrial function in cortical neurons. Neurosci Lett. 2015;590;52-57.
38
Zhang Z, Liu D, Yi B, Liao Z, Tang L, Yin D, He M. Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model. Mol Med Report. 2014;10;2255-2262.
39
Boldyrev AA, Aldini G, Derave W. Physiology and Pathophysiology of Carnosine. Physiol Rev. 2013;93;1803-1845.
40
Cheng J, Wang F, Yu D-F, Wu P-F, Chen J-G. The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons. Eur J Pharmacol. 2011;650;184-194.
41
Fouad AA, El-Rehany MA-A, Maghraby HK. The hepatoprotective effect of carnosine against ischemia/reperfusion liver injury in rats. Eur J Pharmacol. 2007;572;61-68.
42
Fouad AA, Morsy MA, Gomaa W. Protective effect of carnosine against cisplatin-induced nephrotoxicity in mice. Environ Toxicol Pharmacol. 2008;25;292-297.
43
Kurata H, Fujii T, Tsutsui H, Katayama T, Ohkita M, Takaoka M, Tsuruoka N, Kiso Y, Ohno Y, Fujisawa Y, Shokoji T, Nishiyama A, Abe Y, Matsumura Y. Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats. J Pharmacol Exp Ther. 2006;319;640-647.
44
Lee Y-t, Hsu C-c, Lin M-h, Liu K-s, Yin M-c. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur J Pharmacol. 2005;513;145-150.
45
Guiotto A, Calderan A, Ruzza P, Borin G. Carnosine and carnosine-related antioxidants: A Review. Curr Med Chem. 2005;12;2293-2315.
46
Heidari R, Niknahad H, Jamshidzadeh A, Azarpira N, Bazyari M, Najibi A. Carbonyl traps as potential protective agents against methimazole-induced liver injury. J Biochem Mol Toxicol. 2015;29;173-181.
47
Jamshidzadeh A, Heidari R, Latifpour Z, Ommati MM, Abdoli N, Mousavi S, Azarpira N, Zarei A, Zarei M, Asadi B, Abasvali M, Yeganeh Y, Jafari F, Saeedi A, Najibi A, Mardani E. Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats. Clin Res Hepatol Gastroenterol. 2017;41;424-434.
48
Jamshidzadeh A, Abdoli N, Niknahad H, Azarpira N, Mousavi S, Mardani E, Abasvali M, Heidari R. Carnosine supplementation mitigates brain tissue markers of oxidative stress in a rat model of fulminant hepatic failure. Trend Pharm Sci. 2017;3;149-160.
49
Akram J, Reza H, Farzaneh A, Maral R, Forouzan K, Mohammad Mehdi O, Maryam A, Roya F, Arastoo S, Negar A, Asma N. Antimalarial drugs-induced hepatic injury in rats and the protective role of carnosine. Pharm Sci. 2016;22;170-180.
50
Jamshidzadeh A, Niknahad H, Heidari R, Zarei M, Ommati MM, Khodaei F. Carnosine protects brain mitochondria under hyperammonemic conditions: Relevance to hepatic encephalopathy treatment. PharmaNutrition. 2017;5;58-63.
51
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LMT, Ciavardelli D, Rizzarelli E, Sensi SL. Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice. PLoS One. 2011;6;e17971.
52
Hipkiss AR. Aging, proteotoxicity, mitochondria, glycation, NAD+ and carnosine: possible inter-relationships and resolution of the oxygen paradox. Front Aging Neurosci. 2010;2.
53
Caro AA, Adlong LW, Crocker SJ, Gardner MW, Luikart EF, Gron LU. Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria. Toxicol Lett. 2012;214;166-174.
54
Niknahad H, Heidari R, Mohammadzadeh R, Ommati MM, Khodaei F, Azarpira N, Abdoli N, Zarei M, Asadi B, Rasti M, Yeganeh BS, Taheri V, Saeedi A, Najibi A. Sulfasalazine induces mitochondrial dysfunction and renal injury. Ren Fail. 2017;39;745-753.
55
Akram J, Hossein N, Reza H, Maryam A, Forouzan K, Mohammad Reza A, Omid F. Propylthiouracil-induced mitochondrial dysfunction in liver and its relevance to drug-induced hepatotoxicity. 2017;23;95-102.
56
Zhao P, Kalhorn TF, Slattery JT. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology. 2002;36;326-335.
57
Niknahad H, Jamshidzadeh A, Heidari R, Hosseini Z, Mobini K, Khodaei F, Ommati MM, Abdoli N, Keshavarz N, Bazyari M, Najibi A. Paradoxical effect of methimazole on liver mitochondria: In vitro and in vivo. Toxicol Lett. 2016;259;108-115.
58
Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65;55-63.
59
Niknahad H, Heidari R, Alzuhairi AM, Najibi A. Mitochondrial dysfunction as a mechanism for pioglitazone-induced injury toward HepG2 cell line. Pharm Sci. 2015;20;169-174.
60
Ommati MM, Tanideh N, Rezakhaniha B, Wang J, Sabouri S, Vahedi M, Dormanesh B, Koohi Hosseinabadi O, Rahmanifar F, Moosapour S, Akhlaghi A, Heidari R, Zamiri MJ. Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats? Andrology. 2018;6;199-213.
61
Heidari R, Jafari F, Khodaei F, Shirazi Yeganeh B, Niknahad H. Mechanism of valproic acidâinduced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology. 2018;23;351-361.
62
Niknahad H, Jamshidzadeh A, Heidari R, Abdoli N, Mehdi M, Ommati FJ, Zarei M, Asadi B. The postulated hepatotoxic metabolite of methimazole causes mitochondrial dysfunction and energy metabolism disturbances in liver. Pharm Sci. 2016;22;217-226.
63
Heidari R, Babaei H, Eghbal M. Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug Chem Toxicol. 2013;36;403-411.
64
Ahmadian E, Eftekhari A, Fard JK, Babaei H, Nayebi AM, Mohammadnejad D, Eghbal MA. In vitro and in vivo evaluation of the mechanisms of citalopram-induced hepatotoxicity. Arch Pharmacal Res. 2017;40;1296-1313.
65
Eftekhari A, Ahmadian E, Panahi-Azar V, Hosseini H, Tabibiazar M, Dizaj SM. Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. Artificial Cell Nanomed Biotechnol. 2018;46;411-420.
66
Heidari R, Babaei H, Eghbal MA. Cytoprotective effects of organosulfur compounds against methimazole-induced toxicity in isolated rat hepatocytes. Adv Pharm Bull. 2013;3;135-142.
67
Ommati MM, Heidari R, Jamshidzadeh A, Zamiri MJ, Sun Z, Sabouri S, Wang J, Ahmadi F, Javanmard N, Seifi K, Mousapour S, Yeganeh BS. Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models. Toxicol Lett. 2018;284;46-55.
68
Rodriguez-Garay EA. Cholestasis: human disease and experimental animal models. Ann Hepatol. 2003;2;150-158.
69
Pessayre D, Fromenty B, Berson A, Robin M-A, Letteron P, Moreau R, Mansouri A. Central role of mitochondria in drug-induced liver injury. Drug Metab Rev. 2012;44;34-87.
70
Pessayre D, Fromenty B, Mansouri A, Berson A. Hepatotoxicity due to mitochondrial injury. Drug-induced liver disease. 2002;49-84.
71
Hansen SH, Andersen ML, Birkedal H, Cornett C, Wibrand F. The important role of taurine in oxidative metabolism. Adv Exp Med Biol. 2006;583;129-135.
72
Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. 2012;42;2223-2232.
73
Schaffer SW, Azuma J, Mozaffari M. Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol. 2009;87;91-99.
74
Suzuki T, Suzuki T, Wada T, Saigo K, Watanabe K. Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J. 2002;21;6581-6589.
75
Shao A, Hathcock JN. Risk assessment for the amino acids taurine, l-glutamine and l-arginine. Regul Toxicol Pharmacol. 2008;50;376-399.
76
Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M. Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci. 2010;17;S6.
77
Aldini G, Facino RM, Beretta G, Carini M. Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectives. BioFactors. 2005;24;77-87.
78
Zhang Z-y, Sun B-l, Yang M-f, Li D-w, Fang J, Zhang S. Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model. Cell Mol Neurobiol. 2015;35;147-157.
79
Hipkiss AR. Chapter 3 Carnosine and Its Possible Roles in Nutrition and Health. In: Research BTAiF, Nutrition, editors. 57: Academic Press; 2009. p. 87-154.
80
Ommati MM, Jamshidzadeh A, Heidari R, Sun Z, Zamiri MJ, Khodaei F, Mousapour S, Ahmadi F, Javanmard N, Yeganeh BS. Carnosine and histidine supplementation blunt lead-induced reproductive toxicity through antioxidative and mitochondria-dependent mechanisms. Biol Trace Elem Res. 2018;In Press;1-12.
81
Heidari R, Ghanbarinejad V, Ommati MM, Jamshidzadeh A, Niknahad H. Regulation of mitochondrial function and energy metabolism: A primary mechanism of cytoprotection provided by carnosine. Trend Pharm Sci. 2018;4;41-50.
82
ORIGINAL_ARTICLE
Isolation and identification of culturable aerobic halophilic Archaea associated with salt crystals from Urmia Lake
Urmia Lake is one of the largest hypersaline lakes in the world. Water evaporation and saturation cause a lot of salt crystals formation on the lake beach. In this study, extremely halophilic strains were isolated from salt crystals that formed in distinct regions of lake. The isolation was performed by means of modified Marine agar medium and their DNA were extracted and amplified by PCR using universal primers that amplify archaeal 16S rDNA. The amplified archeal DNA fragments were purified, and were subjected to 16S rRNA gene sequencing analysis which was compared to known sequences by a Blast search at NCBI (National Center for Biological Information). Similarity analysis based on 16S rRNA gene sequences of all isolates indicated that the archaeal isolates belong to three different halophilic genera of euryarcheota: Halorubrum, Haloarcula and Halobacterium. These extreme halophilc archaea can be used as a potential source of new therapeutic metabolites and enzymes as well as antibiotic compounds along with novel biotechnological applications.
https://tips.sums.ac.ir/article_42257_a926b046e86da7066b19f765aec14bd0.pdf
2018-06-01
Gholamreza
Zarrini
1
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
AUTHOR
Rana
Rahmani
2
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
AUTHOR
Manica
Negahdaripour
negahdaripour@sums.ac.ir
3
AUTHOR
Miald
Mohkam
4
AUTHOR
Younes
Ghasemi
ghasemiy@sums.ac.ir
5
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
Oren A. Molecular ecology of extremely halophilic Archaea and Bacteria. FEMS Microbiology Ecology. 2002; 39 (1):1-7.
1
Eimanifar A, Mohebbi F. Urmia Lake (northwest Iran): a brief review. Saline systems. 2007; 3 (5):1-8
2
Kanekar P, Kanekar S, Kelkar A, Dhakephalkar P. HalophilesâTaxonomy, diversity, physiology and applications. Microorganisms in Environmental Management: Springer; 2012. p. 1-34.
3
Raghavan T, Furtado I. Occurrence of extremely halophilic Archaea in sediments from the continental shelf of west coast of India. Current Science. 2004; 86 (8):1065-7.
4
Lizama C, Monteoliva-Sanchez M, Suarez-Garcia A, Rosello-Mora R, Aguilera M, Campos V, et al. Halorubrum tebenquichense sp. nov., a novel halophilic archaeon isolated from the Atacama Saltern, Chile. International journal of systematic and evolutionary microbiology. 2002; 52 (1):149-55.
5
Zhang Z, Schwartz S, Wagner L, Miller W. A greedy algorithm for aligning DNA sequences. Journal of Computational biology. 2000; 7 (1-2):203-14.
6
Oren A. Microbial diversity and microbial abundance in salt-saturated brines: why are the waters of hypersaline lakes red? Natural Resources and Environmental Issues. 2009; 15:247.
7
Oren A. Taxonomy of the family Halobacteriaceae: a paradigm for changing concepts in prokaryote systematics. International journal of systematic and evolutionary microbiology. 2012; 62 (2):263-71.
8
Benlloch S, Acinas S, Anton J, Lopez-Lopez A, Luz S, Rodriguez-Valera F. Archaeal biodiversity in crystallizer ponds from a solar saltern: culture versus PCR. Microbial Ecology. 2001; 41(1):12-9.
9
Kerkar S. Ecology of hypersaline microorganisms In Marine Microbiology: Facets and Opportunities, Ed. by Ramaiah N., Goa: National Institute of Oceanography; 2004: pp. 37-47.
10
ORIGINAL_ARTICLE
Protective Effect of Glycine and Tri-Methyl Glycine (Betaine) Against Heavy Metals-Induced Oxidative Stress in Liver-Derived Post-Nuclear Supernatant (PNS)
Heavy metals are environmental pollutants which pose toxicity toward biological systems. Most organs are susceptible to heavy metals-induced toxicity. Hence, finding protective agents against heavy metals-induced toxicity is valuable. The post-nuclear supernatant (PNS) has been accepted as an in vitro model for assessing xenobiotic-induced toxicity toward biological systems. Monitoring the toxic effects of a large number of xenobiotics in a short time is one of the superiorities of PNS system. The goal of the present study was to validate the PNS as an in vitro model for investigating the effect of heavy metals (Cd, Co, Cu, Fe, As, Hg, Cr, and Pb)-induced toxicity and evaluating the potential protective effects of glycine and betaine. Markers of oxidative stress including ROS formation, lipid peroxidation and glutathione content in addition of succinate dehydrogenase activity (MTT test) were monitored in the presence of heavy metals alone or in combination with glycine (1 mM) and betaine (100 µM). Our results suggest that PNS preparations can be used as an appropriate model for future investigation of xenobiotics-induced toxicity and estimation of the protective properties of different agents. Indeed, further evaluations in other experimental models could reveal the protective properties of betaine and glycine against heavy metals-induced organ injury.
https://tips.sums.ac.ir/article_42258_ddb0cb0dfcae00bd4b83c6ac00baf5a2.pdf
2018-06-01
Reza
Heidari
rezaheidari@hotmail.com
1
Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
LEAD_AUTHOR
Hamidreza
Mohammadi
2
AUTHOR
Asrin
Ahmadi
3
AUTHOR
Vahid
Ghanbarinejad
4
AUTHOR
Faraz
Kasra
5
AUTHOR
Amir
Khosravi
6
AUTHOR
Khan S, Cao Q, Zheng YM, Huang YZ, Zhu YG. Health risks of heavy metals in contaminated soils and food crops irrigated with wastewater in Beijing, China. Environ Pollut. 2008;152;686-692.
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10
Heidari R, Jamshidzadeh A, Niknahad H, Safari F, Azizi H, Abdoli N, Ommati MM, Khodaei F, Saeedi A, Najibi A. The hepatoprotection provided by taurine and glycine against antineoplastic drugs induced liver injury in an ex vivo model of normothermic recirculating isolated perfused rat liver. Trend Pharm Sci. 2016;2;59-76.
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Ommati MM, Tanideh N, Rezakhaniha B, Wang J, Sabouri S, Vahedi M, Dormanesh B, Koohi Hosseinabadi O, Rahmanifar F, Moosapour S, Akhlaghi A, Heidari R, Zamiri MJ. Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats? Andrology. 2018;6;199-213.
12
Heidari R, Jafari F, Khodaei F, Shirazi Yeganeh B, Niknahad H. Mechanism of valproic acidâinduced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology. 2018;23;351-361.
13
Heidari R, Babaei H, Ali Eghbal M. Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug Chem Toxicol. 2012;1-9.
14
Abdoli N, Heidari R, Azarmi Y, Eghbal MA. Mechanisms of the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes. J Biochem Mol Toxicol. 2013;27;287-294.
15
Heidari R, Taheri V, Rahimi HR, Shirazi Yeganeh B, Niknahad H, Najibi A. Sulfasalazine-induced renal injury in rats and the protective role of thiol-reductants. Ren Fail. 2016;38;137-141.
16
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18
Ommati MM, Heidari R, Jamshidzadeh A, Zamiri MJ, Sun Z, Sabouri S, Wang J, Ahmadi F, Javanmard N, Seifi K, Mousapour S, Yeganeh BS. Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models. Toxicol Lett. 2018;284;46-55.
19
Heidari R, Babaei H, Roshangar L, Eghbal MA. Effects of enzyme induction and/or glutathione depletion on methimazole-induced hepatotoxicity in mice and the protective role of N-acetylcysteine. Adv Pharm Bull. 2014;4;21-28.
20
Heidari R, Moezi L, Asadi B, Ommati MM, Azarpira N. Hepatoprotective effect of boldine in a bile duct ligated rat model of cholestasis/cirrhosis. PharmaNutrition. 2017;5;109-117.
21
Heidari R, Jamshidzadeh A, Keshavarz N, Azarpira N. Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice. Sci Pharm. 2015;83;143-158.
22
Heidari R, Niknahad H, Sadeghi A, Mohammadi H, Ghanbarinejad V, Ommati MM, Hosseini A, Azarpira N, Khodaei F, Farshad O, Rashidi E, Siavashpour A, Najibi A, Ahmadi A, Jamshidzadeh A. Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury. Biomed Pharmacother. 2018;103;75-86.
23
Jamshidzadeh A, Heidari R, Latifpour Z, Ommati MM, Abdoli N, Mousavi S, Azarpira N, Zarei A, Zarei M, Asadi B, Abasvali M, Yeganeh Y, Jafari F, Saeedi A, Najibi A, Mardani E. Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats. Clin Res Hepatol Gastroenterol. 2017;41;424-434.
24
Ommati MM, Jamshidzadeh A, Heidari R, Sun Z, Zamiri MJ, Khodaei F, Mousapour S, Ahmadi F, Javanmard N, Yeganeh BS. Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms. Biol Trace Elem Res. 2018;In Press;1-12.
25
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26
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27
Heidari R, Jafari F, Khodaei F, Shirazi Yeganeh B, Niknahad H. Mechanism of valproic acid-induced fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology. 2017;23;351-361.
28
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Niknahad H, Jamshidzadeh A, Heidari R, Hosseini Z, Mobini K, Khodaei F, Ommati MM, Abdoli N, Keshavarz N, Bazyari M, Najibi A. Paradoxical effect of methimazole on liver mitochondria: In vitro and in vivo. Toxicol Lett. 2016;259;108-115.
31
Heidari R, Ghanbarinejad V, Mohammadi H, Ahmadi A, Ommati MM, Abdoli N, Aghaei F, Esfandiari A, Azarpira N, Niknahad H. Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. Biomed Pharmacother. 2018;97;1086-1095.
32
Heidari R, Niknahad H, Jamshidzadeh A, Azarpira N, Bazyari M, Najibi A. Carbonyl traps as potential protective agents against methimazole-induced liver injury. J Biochem Mol Toxicol. 2015;29;173-181.
33
Niknahad H, Heidari R, Mohammadzadeh R, Ommati MM, Khodaei F, Azarpira N, Abdoli N, Zarei M, Asadi B, Rasti M, Yeganeh BS, Taheri V, Saeedi A, Najibi A. Sulfasalazine induces mitochondrial dysfunction and renal injury. Ren Fail. 2017;39;745-753.
34
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58
ORIGINAL_ARTICLE
Evaluation of Heavy Metals in Marinara chamomilla and lavandula angustifolia
Today soil and environmental pollution by heavy metals, has become a serious problem for human health. This pollution can be absorbed by agricultural products and enter the body.The purpose of this research is to investigate the contaminant of 2 medicinal plants by 4 heavy metals in shiraz city. To achieve this, 2 kinds of medicinal plants Matricaria chamomilla and Lavandula angustifolia were chosen and then were bought from 6 different herbalist in Shiraz and then were registered in medicinal plants herbarium of school of pharmacy, shiraz university of pharmaceutical sciences. Plarograph was used for measuring the concentration of Copper, Zinc, Cadmium, and Lead in this study. And according to the results, it can be found that the concentration of heavy metals in these two medicinal plants wasn't more than the Standard concentration which was reported for similar plants. And at last it doesn’t need to be worry.
https://tips.sums.ac.ir/article_42259_adf990da52694508d6e86d7c2d0dd235.pdf
2018-06-01
125
130
Sanaz
Shahkarami
1
AUTHOR
Mohammad
Khoshnoud
khoshnoudm@sums.ac.ir
2
LEAD_AUTHOR
Saeid
Akbarzadeh
3
AUTHOR
Hamkhah F., Herbal medicine, Tehran, Asr-e-ketab, 2007
1
Zargari A., Medicinal plants, 1988;281:2-5
2
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8
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14
and distillation equipment on the heavy metal content of waste from an alcoholic anis-type beverage. Journal of hazardous materials. 2003;96(1):53-64.
15
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18
Kazemzadeh Khouei J., Nouri A., Pourang N., Alizadeh M., Ghoreishi J., Padash A., Evaluation of heavy metals Nickel, Lead, Copper, Manganese, Zinc, Cadmium and Vanadium in edible vegetables of south of Tehran. 2012, Biological environment researchs, 3 (6);65-74.
19
Cheraghi M., Ghobadi A., risk assessment of heavy metals (Cadmium, Nickel, Lead and Zinc) in harvested parsley from some farms in Hmaedan, 2014, Tolou-e-Behdasht-e-Yazd Bimonthly Scientific Reaserch, 13(4), 129-143.
20
Hashemi B., Rashidipour M., Rahimi A.., Ghyasvand A., Hosseini F., Evaluating the concentration of heavy metals in 10 medicinal plants in Khoramabad, 2014, Zanko Medical Science journal, 17-25.
21
Koh HL, Woo So. Chinese proprietary medicine in Singapore. Regulatory control of toxic heavy metals and undeclared drugs. Drug safety 2000; 23(5): 351-362.
22
Koh H-L, Woo SO. Chinese proprietary medicine in Singapore: Regulatory control of toxic heavy metals and undeclared drugs. Drug Safe. 2000; 23: 351â362.
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24
Hashemi B., Rashidipour M., Rahimi A.., Ghyasvand A., Hosseini F., Evaluating the concentration of heavy metals in 10 medicinal plants in Khoramabad, 2014, Zanko Medical Science journal, 17-25
25
Kouchaksaraei M., Samadi A.,Mahmoudi A., Evaluating faty acids and low in consumption elements (Iron, Zinc, Copper, Mnganese and Cadmium) in medicinal plants Portulaca, Ms Degree thesis, Iranian Research Institute for Information Science and Technology.
26
Entezari M., Payravand F., Comparative investigating of elements Iron, Zinc, Manganese and Copper in Anethum graveolens and Trigonella foenum-graecum, 2012, Feiz bimonthly science and research, 16 (7), 665-666
27
Hashemi B., Rashidipour M., Rahimi A.., Ghyasvand A., Hosseini F., Evaluating the concentration of heavy metals in 10 medicinal plants in Khoramabad, 2014, Zanko Medical Science journal, 17-25.
28
Kouchaksaraei M., Samadi A.,Mahmoudi A., Evaluating faty acids and low in consumption elements (Iron, Zinc, Copper, Mnganese and Cadmium) in medicinal plants Portulaca, Ms Degree thesis, Iranian Research Institute for Information Science and Technology
29
Kazemzadeh Khouei J., Nouri A., Pourang N., Alizadeh M., Ghoreishi J., Padash A., Evaluation of heavy metals Nickel, Lead, Copper, Manganese, Zinc, Cadmium and Vanadium in edible vegetables of south of Tehran. 2012, Biological environment researchs, 3 (6);65-74.
30
Pourmiri M., evaluating heavy metals (Cadmium, Lead, Mercury) in Herbal Tea which was available in pharmacies of Tehran by using Plarograph, 2014, Phd thesis.
31