In the present report, we describe a middle- age man who experienced decrased visual acuity and metamorphopsia several times since administration of desmpressin nasal spray.Ophthalmologic examination revealed that visual acuity of OD: 4/10 and OS: 9/10 with correction. pigmentary change and retinal elevation was present in fundus examination. Finding was documented with optical coherence tomography (OCT) and Fluorescein angiography (FA).The patient was diagnosed as central serous chorioretinopathy (CSCR) due to consumption of desmopressin nasal spray.We conclude that desmopressin might be developed of CSCR but more study is recommended to confirm this hypothesis that there is association between this kind of drug and development of CSCR.