Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Central serous chorioretinopathy following use of desmopressin nasal spray: A case report
EN
Vahid
Beigi
v.beigi66@gmail.com
Mehrnoosh
Maalhagh
Mohammad sadegh
Beigi
Meisam
Ghanbari
In the present report, we describe a middle- age man who experienced decrased visual acuity and metamorphopsia several times since administration of desmpressin nasal spray.Ophthalmologic examination revealed that visual acuity of OD: 4/10 and OS: 9/10 with correction. pigmentary change and retinal elevation was present in fundus examination. Finding was documented with optical coherence tomography (OCT) and Fluorescein angiography (FA).The patient was diagnosed as central serous chorioretinopathy (CSCR) due to consumption of desmopressin nasal spray.We conclude that desmopressin might be developed of CSCR but more study is recommended to confirm this hypothesis that there is association between this kind of drug and development of CSCR.
https://tips.sums.ac.ir/article_42254.html
https://tips.sums.ac.ir/article_42254_6e2d24d2f13b944c5790acde7eb4f057.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Acute onset bilateral myopia induced by Chlordiazepoxide
EN
Adel
Hamid
Mehrnoosh
Maalhagh
Meisam
Ghanbari
Vahid
Beigi
1- Department of ophthalmology, Poostchi ophthalmology research center, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
v.beigi66@gmail.com
Oral drugs may have adverse effects that affect vision. There are some drugs that are confirmed to induce ciliary effusion such as topiramate. Here we present a case of sudden onset decreased vision after consumption of chlordiazepoxide for a while.
https://tips.sums.ac.ir/article_42255.html
https://tips.sums.ac.ir/article_42255_5ebe758a0d015f7049ff07a36ce1a4a4.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Antidiabetic, Antioxidant, Antibacterial, and Antifungal Activities of Vanadyl Schiff Base Complexes
EN
Susan
Torabi
torabi_s@sums.ac.ir
Mohsen
Mohammadi
Marzieh
Shirvani
This review comprises some biological activities of vanadyl Schiff base complexes in terms of antidiabetic, antioxidant, antibacterial and anti-fungal activity. The structure activity relationship for the potential biological activities of these compounds is also discussed.
https://tips.sums.ac.ir/article_42252.html
https://tips.sums.ac.ir/article_42252_1388f22f657e0235d6536a25118daf38.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Analysis of Fatty Acid Composition of Crude Seed Oil of Lactuca sativa L. by GC-MS and GC Methods
EN
Suleiman
Afsharypuor
afsharypuor@pharm.mui.ac.ir
Mahdieh
Ranjbar
m_ranjbar@dr.com
Mohammad
Mazaheri
mazaherimohammad@yahoo.com
Fereshteh
Shakibaei
shakibaei@med.mui.ac.ir
Abolfazl
Aslani
aslani@pharm.mui.ac.ir
Lactuca sativa L. (Garden Lettuce), is an edible herb cultivated in Iran and other parts of the world. In Traditional Iranian Pharmacy books, garden lettuce is named "Kass Bostani" and Hakim Aqili classified it as a "Ghazā'ye Dawā'ee" (Ghazā means Food; Dawā means Drug). It is said to be soporific, prescribed to cure insomnia and to be useful in thirst and feeling of hotness and burning in the stomach. Seeds of this herb reduce semen, suppress libido and are useful in cases of frequent nocturnal emissions. Fixed oil obtained from seeds of this plant is reputed to have hypnotic and brain moistening properties. In this study we aimed to analyze the fatty acid composition of the crude seed oil of Lactuca sativa L. Methyl esterification of the fatty acids was performed by the method of Ken'ichi Ichihara et al but with a slight modification. Components of the oil were then extracted by n-hexane and analyzed by Gas chromatography-Mass spectroscopy and Gas Chromatography methods. Identified constituents which represented 98.20% of the total elutes were the methyl esters of linoleic (52.38%), oleic (34.42%), palmitic (7.25%), stearic (2.66%), arachidic (1.32%) and myristic (0.17%) acids. Total percentages of methyl esters of the saturated and unsaturated fatty acids identified in our examined oil are 11.4 and 86.80% respectively. In conclusion, seed fat of Lactuca sativa L. like many other plant fats, is rich in unsaturated fatty acids.
https://tips.sums.ac.ir/article_42253.html
https://tips.sums.ac.ir/article_42253_3ebce8113090e1290b86162f1bbc0e0d.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation
EN
Reza
Heidari
0000-0002-7038-9838
Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
rezaheidari@hotmail.com
Narges
Abdoli
Mohammad Mehdi
Ommati
Akram
Jamshidzadeh
0000-0003-4461-7291
ajamshid@sums.ac.ir
Hossein
Niknahad
0000-0001-6211-5936
niknahadh@sums.ac.ir
The cholestatic liver disease ensues with a hepatic accumulation of cytotoxic molecules. Several hydrophobic bile acids are known as cytotoxic agents accumulated in the liver during cholestasis. Chenodeoxycholic acid (CDCA) is a toxic hydrophobic bile acid. Oxidative stress and mitochondrial dysfunction are well-known mechanisms of bile acids cytotoxicity. In the current study, CDCA effect on isolated liver mitochondria was monitored by analyzing the changes in mitochondrial dehydrogenases activity, mitochondrial permeabilization, and mitochondrial membrane potential. On the other hand, taurine (1 mM) and carnosine (1 mM) were added as potential protective agents against CDCA-induced mitochondrial dysfunction. Increasing concentrations of CDCA (100 µM - 1000 µM) impaired mitochondrial membrane potential, decreased mitochondrial dehydrogenases activity and enhanced mitochondrial permeabilization and swelling. It was found that taurine and carnosine supplementation preserved mitochondrial function in the presence of CDCA. The results mention that toxicologically relevant concentrations of CDCA impaired mitochondrial function. On the other hand, taurine and carnosine might be applicable as protective agents against bile acids-induced mitochondrial impairment and toxicity.
https://tips.sums.ac.ir/article_42256.html
https://tips.sums.ac.ir/article_42256_850076220796c1701ba058ab19a155c6.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Isolation and identification of culturable aerobic halophilic Archaea associated with salt crystals from Urmia Lake
EN
Gholamreza
Zarrini
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
Rana
Rahmani
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
Manica
Negahdaripour
0000-0002-4265-1499
negahdaripour@sums.ac.ir
Miald
Mohkam
Younes
Ghasemi
0000-0003-4172-0672
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
ghasemiy@sums.ac.ir
Urmia Lake is one of the largest hypersaline lakes in the world. Water evaporation and saturation cause a lot of salt crystals formation on the lake beach. In this study, extremely halophilic strains were isolated from salt crystals that formed in distinct regions of lake. The isolation was performed by means of modified Marine agar medium and their DNA were extracted and amplified by PCR using universal primers that amplify archaeal 16S rDNA. The amplified archeal DNA fragments were purified, and were subjected to 16S rRNA gene sequencing analysis which was compared to known sequences by a Blast search at NCBI (National Center for Biological Information). Similarity analysis based on 16S rRNA gene sequences of all isolates indicated that the archaeal isolates belong to three different halophilic genera of euryarcheota: Halorubrum, Haloarcula and Halobacterium. These extreme halophilc archaea can be used as a potential source of new therapeutic metabolites and enzymes as well as antibiotic compounds along with novel biotechnological applications.
https://tips.sums.ac.ir/article_42257.html
https://tips.sums.ac.ir/article_42257_a926b046e86da7066b19f765aec14bd0.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Protective Effect of Glycine and Tri-Methyl Glycine (Betaine) Against Heavy Metals-Induced Oxidative Stress in Liver-Derived Post-Nuclear Supernatant (PNS)
EN
Reza
Heidari
0000-0002-7038-9838
Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
rezaheidari@hotmail.com
Hamidreza
Mohammadi
Asrin
Ahmadi
Vahid
Ghanbarinejad
Faraz
Kasra
Amir
Khosravi
Heavy metals are environmental pollutants which pose toxicity toward biological systems. Most organs are susceptible to heavy metals-induced toxicity. Hence, finding protective agents against heavy metals-induced toxicity is valuable. The post-nuclear supernatant (PNS) has been accepted as an in vitro model for assessing xenobiotic-induced toxicity toward biological systems. Monitoring the toxic effects of a large number of xenobiotics in a short time is one of the superiorities of PNS system. The goal of the present study was to validate the PNS as an in vitro model for investigating the effect of heavy metals (Cd, Co, Cu, Fe, As, Hg, Cr, and Pb)-induced toxicity and evaluating the potential protective effects of glycine and betaine. Markers of oxidative stress including ROS formation, lipid peroxidation and glutathione content in addition of succinate dehydrogenase activity (MTT test) were monitored in the presence of heavy metals alone or in combination with glycine (1 mM) and betaine (100 µM). Our results suggest that PNS preparations can be used as an appropriate model for future investigation of xenobiotics-induced toxicity and estimation of the protective properties of different agents. Indeed, further evaluations in other experimental models could reveal the protective properties of betaine and glycine against heavy metals-induced organ injury.
https://tips.sums.ac.ir/article_42258.html
https://tips.sums.ac.ir/article_42258_ddb0cb0dfcae00bd4b83c6ac00baf5a2.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
4
2
2018
06
01
Evaluation of Heavy Metals in Marinara chamomilla and lavandula angustifolia
125
130
EN
Sanaz
Shahkarami
Mohammad
Javad
Khoshnoud
0000-0003-2907-2596
khoshnoudm@sums.ac.ir
Saeid
Akbarzadeh
Today soil and environmental pollution by heavy metals, has become a serious problem for human health. This pollution can be absorbed by agricultural products and enter the body.The purpose of this research is to investigate the contaminant of 2 medicinal plants by 4 heavy metals in shiraz city. To achieve this, 2 kinds of medicinal plants Matricaria chamomilla and Lavandula angustifolia were chosen and then were bought from 6 different herbalist in Shiraz and then were registered in medicinal plants herbarium of school of pharmacy, shiraz university of pharmaceutical sciences. Plarograph was used for measuring the concentration of Copper, Zinc, Cadmium, and Lead in this study. And according to the results, it can be found that the concentration of heavy metals in these two medicinal plants wasn't more than the Standard concentration which was reported for similar plants. And at last it doesn’t need to be worry.
https://tips.sums.ac.ir/article_42259.html
https://tips.sums.ac.ir/article_42259_adf990da52694508d6e86d7c2d0dd235.pdf