Solid-phase nano extraction as a green approach for the analyte isolation

Document Type : Review Article

Authors

1 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

2 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Today rapid and reliable analytical method for determining the trace level of targeted analytes in biological analysis and different fields is an essential object in analysis. So we try to focus on novel methods suggested for improving solid-phase microextraction based on novel drug delivery systems, especially nanoparticles. Nanoparticles like (dendrimer, carbon-based nanoparticles, magnetic and mesoporous nanoparticles, …) and their application as a new sorbent combined with different methods such as solid microextraction and liquid microextraction techniques are discussed in this article. These nano sorbents induced the potentials like selectivity and sensitivity for these methods. Furthermore, this nano extraction caused the lower consumption of hazardous solvent and reduced the total time needed for the extraction procedure, especially in biological analysis. The beneficial effects of nanoparticles indicated that a meaningful future was expected for their application. These new sorbents can be evolved the analytical methods and create reliable and rapid analytical methods.     

Keywords


1.    Olcer YA, Demirkurt M, Demir MM, Eroglu AE. Development of molecularly imprinted polymers (MIPs) as a solid phase extraction (SPE) sorbent for the determination of ibuprofen in water. RSC Advances. 2017;7(50): 31441-31447. http://dx.doi.org/10.1039/C7RA05254E.
2.    Kataoka H, Saito K. Recent advances in SPME techniques in biomedical analysis. J Pharm Biomed Anal. 2011 Apr 5;54(5):926-50. doi: 10.1016/j.jpba.2010.12.010. Epub 2010 Dec 16. PMID: 21194868.
3.    Ashri NY, Abdel-Rehim M. Sample treatment based on extraction techniques in biological matrices. Bioanalysis. 2011 Sep;3(17):2003-18. doi: 10.4155/bio.11.201. PMID: 21899508.
4.    Snow NH. Solid-phase micro-extraction of drugs from biological matrices. J Chromatogr A. 2000 Jul 14;885(1-2):445-55. doi: 10.1016/s0021-9673(00)00192-8. PMID: 10941690.
5.    Alpendurada MF. Solid-phase microextraction: a promising technique for sample preparation in environmental analysis. J Chromatogr A. 2000 Aug 11;889(1-2):3-14. doi: 10.1016/s0021-9673(00)00453-2. PMID: 10985530.
6.    Vas G, Vekey K. Solid‐phase microextraction: a powerful sample preparation tool prior to mass spectrometric analysis. J Mass Spectrom. 2004;39(3):233-54.
7.    Bylda C, Thiele R, Kobold U, Volmer DA. Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS/MS. Analyst. 2014;139(10):2265-76.
8.    Ali I, Gupta V, Aboul‐Enein HY, Hussain A. Hyphenation in sample preparation: Advancement from the micro to the nano world. J Sep Sci. 2008;31(11):2040-53.
9.    Wille SM, Lambert WE. Recent developments in extraction procedures relevant to analytical toxicology. Anal Bioanal Chem. 2007 Aug;388(7):1381-91. doi: 10.1007/s00216-007-1294-z. Epub 2007 Apr 28. PMID: 17468854.
10.    Vogeser M, Kirchhoff F. Progress in automation of LC-MS in laboratory medicine. Clin Biochem. 2011 Jan;44(1):4-13. doi: 10.1016/j.clinbiochem.2010.06.005. Epub 2010 Jun 19. PMID: 20599877.
11.    Bonaventura C, Johnson FM. Healthy environments for healthy people: bioremediation today and tomorrow. Environ Health Perspect. 1997 Feb;105 Suppl 1(Suppl 1):5-20. doi: 10.1289/ehp.97105s15. PMID: 9114274; PMCID: PMC1470315.
12.    Nickerson Beverly. Sample Preparation of Pharmaceutical Dosage Forms: Challenges and Strategies for Sample Preparation and Extraction: Springer Science & Business Media; 2011. DOI: 10.1007/978-1-4419-9631-2.
13.    Abdulra'uf LB, Sirhan AY, Huat Tan G. Recent developments and applications of liquid phase microextraction in fruits and vegetables analysis. J Sep Sci. 2012 Dec;35(24):3540-53. doi: 10.1002/jssc.201200427. PMID: 23225719.
14.    Lord H, Pawliszyn J. Microextraction of drugs. J Chromatogr A. 2000 Dec 1;902(1):17-63. doi: 10.1016/s0021-9673(00)00836-0. PMID: 11192154.
15.    Fabregat-Cabello N, Pitarch-Motellón J, Sancho JV, Ibáñez M, Roig-Navarro AF. Method development and validation for the determination of selected endocrine disrupting compounds by liquid chromatography mass spectrometry and isotope pattern deconvolution in water samples. Comparison of two extraction techniques. Anal Method. 2016;8(14):2895-903.
16.    Pawliszyn J, Pawliszyn B, Pawliszyn M. Solid Phase Microextraction (SPME). Chem Educator. 1997;2(4):1-7.
17.    Naccarato A, Gionfriddo E, Elliani R, Pawliszyn J, Sindona G, Tagarelli A. Investigating the robustness and extraction performance of a matrix-compatible solid-phase microextraction coating in human urine and its application to assess 2-6-ring polycyclic aromatic hydrocarbons using GC-MS/MS. J Sep Sci. 2018 Feb;41(4):929-939. doi: 10.1002/jssc.201700989. Epub 2017 Dec 27. PMID: 29193803.
18.    Berrou K, Dunyach-Remy C, Lavigne JP, Roig B, Cadiere A. Comparison of Stir Bar Sorptive Extraction and Solid Phase Microextraction of Volatile and Semi-Volatile Metabolite Profile of Staphylococcus Aureus. Molecules. 2019 Dec 23;25(1):55. doi: 10.3390/molecules25010055. PMID: 31877955; PMCID: PMC6982899.
19.    Cárdenas S, Lucena R. Recent Advances in Extraction and Stirring Integrated Techniques. Separations. 2017;4(1):6.
20.    Benet Iu, Ibañez C, Guàrdia MD, Solà J, Arnau J, Roura E. Optimisation of stir-bar sorptive extraction (SBSE), targeting medium and long-chain free fatty acids in cooked ham exudates. Food Chem. 2015 Oct 15;185:75-83. doi: 10.1016/j.foodchem.2015.03.102. Epub 2015 Mar 28. PMID: 25952843.
21.    Kazantzi V, Anthemidis A. Fabric sol–gel phase sorptive extraction technique: a review. Separations. 2017;4(2):20.
22.    Hashemi SH, Monfaredzadeh Z. Molecularly Imprinted Stir Bar Sorptive Extraction Coupled with High-Performance Liquid Chromatography for Trace Analysis of Diclofenac in Different Real Samples. Iran J Chem Chem Engin (IJCCE). 2019;38(1):173-83.
23.    Kataoka H, Ishizaki A, Saito K. Recent progress in solid-phase microextraction and its pharmaceutical and biomedical applications. Anal Methods. 2016;8(29):5773-88.
24.    Dadalı C, Elmacı Y. Optimization of Headspace-Solid Phase Microextraction (HS-SPME) technique for the analysis of volatile compounds of margarine. J Food Sci Technol. 2019 Nov;56(11):4834-4843. doi: 10.1007/s13197-019-03945-w. Epub 2019 Aug 1. PMID: 31741508; PMCID: PMC6828873.
25.    Kataoka H, Saito K. Recent advances in SPME techniques in biomedical analysis. J Pharm Biomed Anal. 2011;54(5):926-50.
26.    Attari SG, Bahrami A, Shahna FG, Heidari M. Solid-phase microextraction fiber development for sampling and analysis of volatile organohalogen compounds in air. J Environ Health Sci Engineer. 2014;12(1):123-.
27.    Mieth M, Schubert JK, Gröger T, Sabel B, Kischkel S, Fuchs P, Hein D, Zimmermann R, Miekisch W. Automated needle trap heart-cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment. Anal Chem. 2010 Mar 15;82(6):2541-51. doi: 10.1021/ac100061k. PMID: 20170082.
28.    Moliner-Martinez Y, Herráez-Hernández R, Verdú-Andrés J, Molins-Legua C, Campíns-Falcó P. Recent advances of in-tube solid-phase microextraction. TrAC Trends  Anal Chem. 2015;71:205-13.
29.    Fernández-Amado M, Prieto-Blanco MC, López-Mahía P, Muniategui-Lorenzo S, Prada-Rodríguez D. Strengths and weaknesses of in-tube solid-phase microextraction: A scoping review. Anal Chim Acta. 2016 Feb 4;906:41-57. doi: 10.1016/j.aca.2015.12.007. Epub 2015 Dec 17. PMID: 26772124.
30.    Wang H, Huang C, Ma S, Bo C, Ou J, Gong B. Recent advances of restricted access molecularly imprinted materials and their applications in food and biological samples analysis. TrAC Trends  Anal Chem. 2022:116526.
31.    Ponce-Rodríguez HD, Verdú-Andrés J, Herráez-Hernández R, Campíns-Falcó P. Innovations in Extractive Phases for In-Tube Solid-Phase Microextraction Coupled to Miniaturized Liquid Chromatography: A Critical Review. Molecules. 2020 May 25;25(10):2460. doi: 10.3390/molecules25102460. PMID: 32466305; PMCID: PMC7287690.
32.    Hutchinson JP, Setkova L, Pawliszyn J. Automation of solid-phase microextraction on a 96-well plate format. J Chromatogr A. 2007 May 18;1149(2):127-37. doi: 10.1016/j.chroma.2007.02.117. Epub 2007 Mar 16. PMID: 17418854.
33.    Kailasa SK, Wu HF. Recent Advances in Mass Spectrometry for the Identification of Neuro-chemicals and their Metabolites in Biofluids. Curr Neuropharmacol. 2013 Jul;11(4):436-64. doi: 10.2174/1570159X11311040007. PMID: 24381533; PMCID: PMC3744906.
34.    Hamidi S, Alipour-Ghorbani N. Liquid-phase microextraction of biomarkers: A review on current methods. J Liq Chromatogr Relat. 2017;40(16):853-61.
35.    Macklin A, Khan S, Kislinger T. Recent advances in mass spectrometry based clinical proteomics: applications to cancer research. Clin Proteomics. 2020 May 24;17:17. doi: 10.1186/s12014-020-09283-w. PMID: 32489335; PMCID: PMC7247207.
36.    Ouyang G, Zhao W, Pawliszyn J. Automation and optimization of liquid-phase microextraction by gas chromatography. J Chromatogr A. 2007 Jan 5;1138(1-2):47-54. doi: 10.1016/j.chroma.2006.10.093. Epub 2006 Nov 20. PMID: 17116305.
37.    Rafiei Jam M, Nezhadali A, Kaykhaii M. Application of gas flow headspace liquid phase micro extraction coupled with gas chromatography-mass spectrometry for determination of 4-methylimidazole in food samples employing experimental design optimization. BMC Chem. 2022 May 6;16(1):29. doi: 10.1186/s13065-022-00823-z. PMID: 35524272; PMCID: PMC9077832.
38.    Xu L, Basheer C, Lee HK. Developments in single-drop microextraction. J Chromatogr A. 2007;1152(1-2):184-92.
39.    Kailasa SK, Wu HF. Single-drop microextraction for bioanalysis: present and future. Bioanalysis. 2013 Nov;5(21):2593-6. doi: 10.4155/bio.13.231. PMID: 24180499.
40.    Tang S, Qi T, Ansah PD, Nalouzebi Fouemina JC, Shen W, Basheer C, et al. Single-drop microextraction. TrAC, Trends Anal Chem. 2018;108:306-13.
41.    Medina DAV, Rodriguez Cabal LF, Lanças FM, Santos-Neto ÁJ. Sample treatment platform for automated integration of microextraction techniques and liquid chromatography analysis. HardwareX. 2019;5:e00056.
42.    Fabre M, Aubry V, Guichard E. Comparison of different methods: static and dynamic headspace and solid-phase microextraction for the measurement of interactions between milk proteins and flavor compounds with an application to emulsions. J Agric Food Chem. 2002 Mar 13;50(6):1497-501. doi: 10.1021/jf010706s. PMID: 11879027.
43.    Moinfar S, Khayatian G, Milani-Hosseini MR. Continuous sample drop flow-based microextraction method as a microextraction technique for determination of organic compounds in water sample. Talanta. 2014 Nov;129:309-14. doi: 10.1016/j.talanta.2014.05.058. Epub 2014 Jun 10. PMID: 25127600.
44.    Sarafraz-Yazdi A, Amiri A. Liquid-phase microextraction. TrAC, Trends Anal Chem. 2010;29(1):1-14.
45.    Viñas P, Martínez-Castillo N, Campillo N, Hernández-Córdoba M. Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography-mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods. J Chromatogr A. 2011 Feb 4;1218(5):639-46. doi: 10.1016/j.chroma.2010.12.026. Epub 2010 Dec 14. PMID: 21185565.
46.    Havlikova M, Cabala R, Pacakova V, Bosakova Z. Critical evaluation of microextraction pretreatment techniques-Part 2: Membrane-supported and homogenous phase based techniques. J Sep Sci. 2019 Jan;42(1):303-318. doi: 10.1002/jssc.201800903. Epub 2018 Nov 14. PMID: 30367551.
47.    Einsle T, Paschke H, Bruns K, Schrader S, Popp P, Moeder M. Membrane-assisted liquid-liquid extraction coupled with gas chromatography-mass spectrometry for determination of selected polycyclic musk compounds and drugs in water samples. J Chromatogr A. 2006 Aug 18;1124(1-2):196-204. doi: 10.1016/j.chroma.2006.06.093. Epub 2006 Jul 25. PMID: 16870197.
48.    Zgoła-Grześkowiak A, Grześkowiak T. Dispersive liquid-liquid microextraction. TrAC, Trends Anal Chem. 2011;30(9):1382-99.
49.    Azzouz A, Kailasa SK, Lee SS, J. Rascón A, Ballesteros E, Zhang M, et al. Review of nanomaterials as sorbents in solid-phase extraction for environmental samples. TrAC, Trends Anal Chem.  2018;108:347-69.
50.    Patel DK, Kim HB, Dutta SD, Ganguly K, Lim KT. Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications. Materials (Basel). 2020 Apr 3;13(7):1679. doi: 10.3390/ma13071679. PMID: 32260227; PMCID: PMC7178645.
51.    Mehdinia A, Aziz-Zanjani MO. Recent advances in nanomaterials utilized in fiber coatings for solid-phase microextraction. TrAC, Trends Anal Chem. 2013;42:205-15.
52.    Fresco-Cala B, Cárdenas S, Herrero-Martínez J. Preparation of porous methacrylate monoliths with oxidized single-walled carbon nanohorns for the extraction of nonsteroidal anti-inflammatory drugs from urine samples. Microchim Acta. 2017;184.
53.    Fresco-Cala B, Cárdenas S, Valcárcel M. Preparation and evaluation of micro and meso porous silica monoliths with embedded carbon nanoparticles for the extraction of non-polar compounds from waters. J Chromatogr A. 2016 Oct 14;1468:55-63. doi: 10.1016/j.chroma.2016.09.047. Epub 2016 Sep 22. PMID: 27692641.
54.    ALOthman ZA, Wabaidur SM. Application of carbon nanotubes in extraction and chromatographic analysis: a review. Arab J Chem. 2019;12(5):633-51.
55.    Fresco-Cala B, Mompó-Roselló Ó, Simó-Alfonso EF, Cárdenas S, Herrero-Martínez JM. Carbon nanotube-modified monolithic polymethacrylate pipette tips for (micro)solid-phase extraction of antidepressants from urine samples. Mikrochim Acta. 2018 Jan 24;185(2):127. doi: 10.1007/s00604-017-2659-4. PMID: 29594510.
56.    Tang L, Cheng J. Nonporous Silica Nanoparticles for Nanomedicine Application. Nano Today. 2013 Jun;8(3):290-312. doi: 10.1016/j.nantod.2013.04.007. PMID: 23997809; PMCID: PMC3757135.
57.    Jeelani PG, Mulay P, Venkat R, Ramalingam C. Multifaceted Application of Silica Nanoparticles. A Review. Silicon. 2020;12(6):1337-54.
58.    Bapat G, Labade C, Chaudhari A, Zinjarde S. Silica nanoparticle based techniques for extraction, detection, and degradation of pesticides. Adv Colloid Interface Sci. 2016 Nov;237:1-14. doi: 10.1016/j.cis.2016.06.001. Epub 2016 Jun 10. PMID: 27780560.
59.    Farjadian F, Azadi S, Mohammadi-Samani S, Ashrafi H, Azadi A. A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs. Heliyon. 2018 Nov 12;4(11):e00930. doi: 10.1016/j.heliyon.2018.e00930. PMID: 30456326; PMCID: PMC6234517.
60.    González-Fuenzalida RA, Moliner-Martínez Y, Prima-Garcia H, Ribera A, Campins-Falcó P, Zaragozá RJ. Evaluation of Superparamagnetic Silica Nanoparticles for Extraction of Triazines in Magnetic in-Tube Solid Phase Microextraction Coupled to Capillary Liquid Chromatography. Nanomaterials (Basel). 2014 Apr 2;4(2):242-255. doi: 10.3390/nano4020242. PMID: 28344221; PMCID: PMC5304668.
61.    de Souza KC, Andrade GF, Vasconcelos I, de Oliveira Viana IM, Fernandes C, de Sousa EM. Magnetic solid-phase extraction based on mesoporous silica-coated magnetic nanoparticles for analysis of oral antidiabetic drugs in human plasma. Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:275-80. doi: 10.1016/j.msec.2014.04.004. Epub 2014 Apr 12. PMID: 24857494.
62.    Mehdinia A, Khojasteh E, Baradaran Kayyal T, Jabbari A. Magnetic solid phase extraction using gold immobilized magnetic mesoporous silica nanoparticles coupled with dispersive liquid-liquid microextraction for determination of polycyclic aromatic hydrocarbons. J Chromatogr A. 2014 Oct 17;1364:20-7. doi: 10.1016/j.chroma.2014.08.063. Epub 2014 Aug 26. PMID: 25194625.
63.    Shirkhanloo H, Davari S, Hosseini F. Dispersive solid phase microextraction based on aminefunctionalized bimodal mesoporous silica nanoparticles for separation and determination of calcium ions in chronic kidney disease. Anal Meth Environ Chem J. 2018;1:57-66.
64.    Li T, Xu J, Wu JH, Feng YQ. Liquid-phase deposition of silica nanoparticles into a capillary for in-tube solid-phase microextraction coupled with high-performance liquid chromatography. J Chromatogr A. 2009 Apr 10;1216(15):2989-95. doi: 10.1016/j.chroma.2009.01.076. Epub 2009 Jan 29. PMID: 19211102.
65.    Płotka-Wasylka J, Marć M, Szczepańska N, Namieśnik J. New Polymeric Materials for Solid Phase Extraction. Crit Rev Anal Chem. 2017 Sep 3;47(5):373-383. doi: 10.1080/10408347.2017.1298987. Epub 2017 Apr 11. PMID: 28398080.
66.    Abbasi E, Aval SF, Akbarzadeh A, Milani M, Nasrabadi HT, Joo SW, Hanifehpour Y, Nejati-Koshki K, Pashaei-Asl R. Dendrimers: synthesis, applications, and properties. Nanoscale Res Lett. 2014 May 21;9(1):247. doi: 10.1186/1556-276X-9-247. PMID: 24994950; PMCID: PMC4074873.
67.    Massoumi B, Jaymand M. Nanostructured star-shaped polythiophene with tannic acid core: Synthesis, characterization, and its physicochemical properties. J Appl Polym Sci. 2016;133(23).
68.    Abolghasemi MM, Habibiyan R, Jaymand M, Piryaei M. A star-shaped polythiophene dendrimer coating for solid-phase microextraction of triazole agrochemicals. Mikrochim Acta. 2018 Feb 14;185(3):179. doi: 10.1007/s00604-017-2639-8. PMID: 29594604.
69.    Alinezhad H, Amiri A, Tarahomi M, Maleki B. Magnetic solid-phase extraction of non-steroidal anti-inflammatory drugs from environmental water samples using polyamidoamine dendrimer functionalized with magnetite nanoparticles as a sorbent. Talanta. 2018 Jun 1;183:149-157. doi: 10.1016/j.talanta.2018.02.069. Epub 2018 Feb 16. PMID: 29567157.
70.    Wu Y, Chen C, Zhou Q, Li QX, Yuan Y, Tong Y, Wang H, Zhou X, Sun Y, Sheng X. Polyamidoamine dendrimer decorated nanoparticles as an adsorbent for magnetic solid-phase extraction of tetrabromobisphenol A and 4-nonylphenol from environmental water samples. J Colloid Interface Sci. 2019 Mar 15;539:361-369. doi: 10.1016/j.jcis.2018.12.064. Epub 2018 Dec 17. PMID: 30594011.
71.    Saikia C, Gogoi P. Chitosan: A Promising Biopolymer in Drug Delivery Applications. J Mol Genet Med. 2015;s4:006.
72.    Azarova YA, Pestov AV, Bratskaya SY. Application of chitosan and its derivatives for solid-phase extraction of metal and metalloid ions: a mini-review. Cellulose. 2016;23(4):2273-89.
73.    Djerahov L, Vasileva P, Karadjova I, Kurakalva RM, Aradhi KK. Chitosan film loaded with silver nanoparticles-sorbent for solid phase extraction of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II). Carbohydr Polym. 2016 Aug 20;147:45-52. doi: 10.1016/j.carbpol.2016.03.080. Epub 2016 Mar 29. PMID: 27178907.
74.    Razavi N, Sarafraz Yazdi A. New application of chitosan-grafted polyaniline in dispersive solid-phase extraction for the separation and determination of phthalate esters in milk using high-performance liquid chromatography. J Sep Sci. 2017 Apr;40(8):1739-1746. doi: 10.1002/jssc.201601059. Epub 2017 Mar 29. PMID: 28225187.
75.    Tamayo FG, Turiel E, Martín-Esteban A. Molecularly imprinted polymers for solid-phase extraction and solid-phase microextraction: recent developments and future trends. J Chromatogr A. 2007 Jun 8;1152(1-2):32-40. doi: 10.1016/j.chroma.2006.08.095. Epub 2006 Sep 28. PMID: 17010356.
76.    Santos H, Martins R, Soares D, Chaves A. Molecularly imprinted polymers for miniaturized sample preparation techniques: strategies for chromatographic and mass spectrometry methods. Anal Methods. 2020;12(7):894-911.
77.    Wang GN, Yang K, Liu HZ, Feng MX, Wang JP. Molecularly imprinted polymer-based solid phase extraction combined high performance liquid chromatography for determination of fluoroquinolones in milk. Anal Methods. 2016;8(27):5511-8.
78.    Habibi B, Rostamkhani S, Hamidi M. Magnetic molecularly imprinted polymer nanoparticles for dispersive micro solid-phase extraction and determination of buprenorphine in human urine samples by HPLC-FL. J Iran Chem Soc. 2018;15(7):1569-80.
79.    Kaabipour M, Khodadoust S, Zeraatpisheh F. Preparation of magnetic molecularly imprinted polymer for dispersive solid-phase extraction of valsartan and its determination by high-performance liquid chromatography: Box-Behnken design. J Sep Sci. 2020;43(5):912-9.
80.    Vergara-Barberán M, Lerma-García MJ, Simó-Alfonso EF, Herrero-Martínez JM. Polymeric sorbents modified with gold and silver nanoparticles for solid-phase extraction of proteins followed by MALDI-TOF analysis. Microchim Acta. 2017;184(6):1683-90.
81.    Mafu LD, Msagati TA, Mamba BB. Ion-imprinted polymers for environmental monitoring of inorganic pollutants: synthesis, characterization, and applications. Environ Sci Pollut Res Int. 2013 Feb;20(2):790-802. doi: 10.1007/s11356-012-1215-3. Epub 2012 Oct 4. PMID: 23054781.
82.    Wang N, Xin H, Zhang Q, Jiang Y, Wang X, Shou D, et al. Carbon nanotube-polymer composite for effervescent pipette tip solid phase microextraction of alkaloids and flavonoids from Epimedii herba in biological samples. Talanta. 2017;162:10-8.
83.    Loussala HM, Feng J, Han S, Sun M, Ji X, Li C, et al. Carbon nanotubes functionalized mesoporous silica for in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons. J Sep Sci. 2020;43(16):3275-84.
84.    Mirzapour H, Panahi HA, Moniri E, Feizbakhsh A. Magnetic nanoparticles modified with organic dendrimers containing methyl methacrylate and ethylene diamine for the microextraction of rosuvastatin. Microchim Acta. 2018;185(9):440.
85.    Bagheri H, Manouchehri M, Allahdadlalouni M. A magnetic multifunctional dendrimeric coating on a steel fiber for solid phase microextraction of chlorophenols. Microchim Acta. 2017;184(7):2201-9.
86.    Ramezani Z, Saeedi I, Hashemi P. Dendrimer grafted nanoporous silica fibers for headspace solid phase microextraction coupled to gas chromatography determination of solvent residues in edible oil. Anal Methods. 2018;10(11):1379-84.
87.    Liu F, Yang X, Wu X, Xi X, Gao H, Zhang S, et al. A dispersive magnetic solid phase microextraction based on ionic liquid-coated and cyclodextrin-functionalized magnetic core dendrimer nanocomposites for the determination of pyrethroids in juice samples. Food Chem. 2018 Dec 1;268:485-491. doi: 10.1016/j.foodchem.2018.06.105. Epub 2018 Jun 27. PMID: 30064787.
88.    Azimi S, Es'haghi Z, Bardajee GR. Dendrimer-reinforced sol-gel based hollow fiber solid-phase microextraction for citalopram determination using response surface methodology. J Sep Sci. 2017 May;40(10):2246-2252. doi: 10.1002/jssc.201601429. Epub 2017 Apr 12. PMID: 28323381.
89.    Badawy MEI, El-Nouby MAM, Marei AEM. Development of a Solid-Phase Extraction (SPE) Cartridge Based on Chitosan-Metal Oxide Nanoparticles (Ch-MO NPs) for Extraction of Pesticides from Water and Determination by HPLC. Int J Anal Chem. 2018 Oct 2;2018:3640691. doi: 10.1155/2018/3640691. PMID: 30369950; PMCID: PMC6189673.
90.    Alcudia-León MC, Lucena R, Cárdenas S, Valcárcel M. Determination of parabens in waters by magnetically confined hydrophobic nanoparticle microextraction coupled to gas chromatography/mass spectrometry. Microchem J. 2013;110:643-8.
91.    Tahmasebi E, Yamini Y, Mehdinia A, Rouhi F. Polyaniline-coated Fe3O4 nanoparticles: An anion exchange magnetic sorbent for solid-phase extraction. J Sep Sci. 2012 Sep;35(17):2256-65. doi: 10.1002/jssc.201200345. Epub 2012 Jul 26. PMID: 22833522.