TY - JOUR ID - 44932 TI - Intracranial hemorrhage after carotid artery stenting in two patients taking omega-3 fatty acids with dual antiplatelet therapy: two case reports JO - Trends in Pharmaceutical Sciences JA - TIPS LA - en SN - 2423-3722 AU - Foroughinia, Farzaneh AU - Borhani-Haghighi, Afshin AU - Jamshidi, Elaheh AU - Javanmardi, Haniyeh AD - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2019 PY - 2019 VL - 5 IS - 1 SP - 1 EP - 6 KW - Intracranial Hemorrhage KW - Carotid artery stenting KW - Fatty acids KW - Omega-3 KW - Dual antiplatelets DO - 10.30476/tips.2019.81725.1005 N2 - Patients undergoing Carotid Artery Stenting (CAS) may encounter serious complications including Intracranial hemorrhage (ICH). ICH after carotid re-vascularization has been usually attributed to cerebral hyperperfusion syndrome (CHS) and it is reported as a significant cause of mortality and morbidity. Factors mentioned as risk factors for ICH after carotid intervention are preoperative hypertension, renal failure, bilateral carotid disease or contralateral carotid occlusion, impaired cerebrovascular reserve, female gender, age, nonselective admission, increased Charlson comorbidities score. In this study, we report two cases of ICH after CAS in patients receiving dual antiplatelet regimen plus omega-3 fatty acids before and after carotid intervention. It seems that administration of omega 3 with other antiplatelets could augment inhibition of platelet aggregation and may increase the risk of ICH in patients undergoing CAS especially in those with several risk factors for ICH. These findings are important because of the wide availability of omega-3 supplements as an over-the-counter (OTC) drug and the propensity for usage of it in alternative medicine. UR - https://tips.sums.ac.ir/article_44932.html L1 - https://tips.sums.ac.ir/article_44932_070dbb1b48005cf9832b21c685a7457f.pdf ER -