Antioxidant, antidiabetic, antibacterial and antifungal activities of vanadyl Schiff base complexes

Susan Torabi, Mohsen Mohammadi, Marzieh Shirvani


Compounds of the trace element vanadium exert various insulin-like effects in vitro and in vivo systems. These include their ability to improve glucose homeostasis and insulin resistance in animal models of Type 1 and Type 2 diabetes mellitus.

Antioxidants and antibacterials are important in the prevention of human diseases. Studies on vanadyl Schiff base complexes have shown that some of them are involved in important biological processes, such as antioxidant, antibacterial and antifungal activity. The simple Schiff bases showed weaker to significant activity against one or more bacterial and fungal strains. In most of the cases the oxovanadium(IV) complexes showed  higher antimicrobial effect than free ligands. It is, therefore evident that coordination makes the ligands strongly antibacterial agent and inhibits the growth of bacteria more than the parent uncomplexed ligand.



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