Graphene: recent advances in engineering, medical and biological sciences, and future prospective

Fatemeh Emadi, Abbas Amini, Younes Ghasemi, Ahmad Gholami


Graphene, a two dimensional carbon allotrope, has been appeared as an interesting material of the 21st century, and received world-wide attention due to its extraordinary thermal, optical, and mechanical properties. Graphene and its derivatives are being studied in different field of science from medicine and pharmaceutics to engineering and industries. Graphene materials have mainly been explored in electronics, clean energy devices, biosensors and environmental remediation also in biomedicine field, their antimicrobial activity and their capacity as drug delivery or gene delivery platforms and tissue engineering scaffold have been reported. This article provides an overview of graphene and its recent advances in different fields including biomedicine and industries.

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Novoselov, K., Nobel lecture: Graphene: Materials in the flatland. Reviews of Modern Physics, 2011. 83(3): p. 837.

Stankovich, S., et al., Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide. carbon, 2007. 45(7): p. 1558-1565.

Shioyama, H., Cleavage of graphite to graphene. Journal of materials science letters, 2001. 20(6): p. 499-500.

Hirsch, A., The era of carbon allotropes. Nature materials, 2010. 9(11): p. 868.

Singh, D.P., et al., Graphene oxide: An efficient material and recent approach for biotechnological and biomedical applications. Materials Science and Engineering: C, 2018.

Zhu, Y., et al., Graphene and graphene oxide: synthesis, properties, and applications. Advanced materials, 2010. 22(35): p. 3906-3924.

Shareena, T.P.D., et al., A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health. Nano-Micro Letters, 2018. 10(3): p. 53.

Kumar, A., et al., Tunable field effect properties in solid state and flexible graphene electronics on composite high–low k dielectric. Carbon, 2016. 99: p. 579-584.

Neto, A.C., et al., The electronic properties of graphene. Reviews of modern physics, 2009. 81(1): p. 109.

Avouris, P., Graphene: electronic and photonic properties and devices. Nano letters, 2010. 10(11): p. 4285-4294.

Wang, J., et al., Rod‐coating: towards large‐area fabrication of uniform reduced graphene oxide films for flexible touch screens. Advanced Materials, 2012. 24(21): p. 2874-2878.

Shao, Y., et al., Graphene based electrochemical sensors and biosensors: a review. Electroanalysis, 2010. 22(10): p. 1027-1036.

Kuila, T., et al., Recent advances in graphene-based biosensors. Biosensors and Bioelectronics, 2011. 26(12): p. 4637-4648.

Peng, J., et al., Blue-light photoelectrochemical sensor based on nickel tetra-amined phthalocyanine-graphene oxide covalent compound for ultrasensitive detection of erythromycin. Biosensors and Bioelectronics, 2018. 106: p. 212-218.

Liu, J., et al., Molecularly engineered graphene surfaces for sensing applications: A review. Analytica chimica acta, 2015. 859: p. 1-19.

Mohanty, N. and V. Berry, Graphene-based single-bacterium resolution biodevice and DNA transistor: interfacing graphene derivatives with nanoscale and microscale biocomponents. Nano letters, 2008. 8(12): p. 4469-4476.

Bollella, P., et al., Beyond graphene: electrochemical sensors and biosensors for biomarkers detection. Biosensors and Bioelectronics, 2017. 89: p. 152-166.

Orecchioni, M., et al., Graphene and the immune system: challenges and potentiality. Advanced drug delivery reviews, 2016. 105: p. 163-175.

Li, X., et al., Carbon and graphene quantum dots for optoelectronic and energy devices: a review. Advanced Functional Materials, 2015. 25(31): p. 4929-4947.

Petridis, K., et al., Graphene‐Based Inverted Planar Perovskite Solar Cells: Advancements, Fundamental Challenges, and Prospects. Chemistry–An Asian Journal, 2018. 13(3): p. 240-249.

Liang, M., B. Luo, and L. Zhi, Application of graphene and graphene‐based materials in clean energy‐related devices. International Journal of Energy Research, 2009. 33(13): p. 1161-1170.

Miller, J.R., R. Outlaw, and B. Holloway, Graphene double-layer capacitor with ac line-filtering performance. Science, 2010. 329(5999): p. 1637-1639.

Wang, S., et al., Adsorptive remediation of environmental pollutants using novel graphene-based nanomaterials. Chemical Engineering Journal, 2013. 226: p. 336-347.

Munuera, J., et al., High quality, low-oxidized graphene via anodic exfoliation with table salt as an efficient oxidation-preventing co-electrolyte for water/oil remediation and capacitive energy storage applications. Applied Materials Today, 2018. 11: p. 246-254.

Kim, J.M., et al., Toluene and acetaldehyde removal from air on to graphene-based adsorbents with microsized pores. Journal of hazardous materials, 2018. 344: p. 458-465.

Zhao, P., et al., Sodium alginate/graphene oxide hydrogel beads as permeable reactive barrier material for the remediation of ciprofloxacin-contaminated groundwater. Chemosphere, 2018. 200: p. 612-620.

Li, Z.-J., et al., Efficient removal of uranium from aqueous solution by zero-valent iron nanoparticle and its graphene composite. Journal of hazardous materials, 2015. 290: p. 26-33.

Liu, Z., et al., PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. Journal of the American Chemical Society, 2008. 130(33): p. 10876-10877.

Yang, K., L. Feng, and Z. Liu, The advancing uses of nano-graphene in drug delivery. Expert opinion on drug delivery, 2015. 12(4): p. 601-612.

Yang, X., et al., High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. The Journal of Physical Chemistry C, 2008. 112(45): p. 17554-17558.

Zhang, L., et al., Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small, 2010. 6(4): p. 537-544.

Li, S. and L. Huang, Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene therapy, 2006. 13(18): p. 1313.

Balapanuru, J., et al., A Graphene Oxide–Organic Dye Ionic Complex with DNA‐Sensing and Optical‐Limiting Properties. Angewandte Chemie, 2010. 122(37): p. 6699-6703.

Xu, C., et al., Encapsulating gold nanoparticles or nanorods in graphene oxide shells as a novel gene vector. ACS applied materials & interfaces, 2013. 5(7): p. 2715-2724.

Bao, H., et al., Chitosan‐functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small, 2011. 7(11): p. 1569-1578.

Zhang, L., et al., Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI‐grafted graphene oxide. Small, 2011. 7(4): p. 460-464.

Paul, A., et al., Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS nano, 2014. 8(8): p. 8050-8062.

Yue, H., et al., Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing. Nanoscale, 2018.

Lu, Y.-J., et al., Magnetic Graphene Oxide for Dual Targeted Delivery of Doxorubicin and Photothermal Therapy. Nanomaterials, 2018. 8(4): p. 193.

Yang, K., et al., Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Advanced materials, 2012. 24(14): p. 1868-1872.

Zhang, W., et al., Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide. Biomaterials, 2011. 32(33): p. 8555-8561.

Lee, W.C., et al., Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. ACS nano, 2011. 5(9): p. 7334-7341.

Goenka, S., V. Sant, and S. Sant, Graphene-based nanomaterials for drug delivery and tissue engineering. Journal of Controlled Release, 2014. 173: p. 75-88.

Raucci, M., et al., Comparative facile methods for preparing graphene oxide–hydroxyapatite for bone tissue engineering. Journal of tissue engineering and regenerative medicine, 2017. 11(8): p. 2204-2216.

Sivashankari, P. and M. Prabaharan, Chitosan/carbon-based nanomaterials as scaffolds for tissue engineering, in Biopolymer-Based Composites. 2018, Elsevier. p. 381-397.

Fan, H., et al., Fabrication, mechanical properties, and biocompatibility of graphene-reinforced chitosan composites. Biomacromolecules, 2010. 11(9): p. 2345-2351.

Depan, D., J. Shah, and R. Misra, Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Materials Science and Engineering: C, 2011. 31(7): p. 1305-1312.

Wang, Y., et al., Fluorinated Graphene for Promoting Neuro‐Induction of Stem Cells. Advanced Materials, 2012. 24(31): p. 4285-4290.

Revathi, S., T. Guna, and P. Kathirvel, Applications of Graphene in Biomedical Field. 2018.

Podila, R., et al., Graphene coatings for enhanced hemo-compatibility of nitinol stents. RSC Advances, 2013. 3(6): p. 1660-1665.

Wang, C.-H., et al., Effects of graphene modification on the bioactivation of polyethylene-terephthalate-based artificial ligaments. ACS applied materials & interfaces, 2015. 7(28): p. 15263-15276.

Sava, S., et al., Effects of graphene addition on the mechanical properties of composites for dental restoration. Mater. Plast, 2015. 52: p. 90-92.

Kulshrestha, S., et al., A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans. Biofouling, 2014. 30(10): p. 1281-1294.

Rosa, V., et al., Graphene oxide-based substrate: physical and surface characterization, cytocompatibility and differentiation potential of dental pulp stem cells. Dental Materials, 2016. 32(8): p. 1019-1025.

Su, I.-h., et al., Evaluating a Cobalt‐Tetraphenylporphyrin Complex, Functionalized with a Reduced Graphene Oxide Nanocomposite, for Improved Tooth Whitening. Journal of Esthetic and Restorative Dentistry, 2016. 28(5): p. 321-329.

Xiao, X., Y. Li, and Z. Liu, Graphene commercialization. Nature materials, 2016. 15(7): p. 697.



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