Biotechnology: employing organism as bioreactors

Maryam Baniasad, Zohreh Amoozgar

Abstract


Biological products, especially proteins, have numerous applications including prevention, diagnosis, and treating diseases. Advances in biotechnology in recent years have opened up many ways to manufacture these products in large scales. To engineer biopharmaceuticals, often pro and/or eukaryotic sustainable resources are used. Selection of the cellular factory depends on the type and application of protein needed. In this review, we explore current resources used to produce biologics, examine these resources critically for their biological output, and finally highlight impact of using sustainable resources in modern medicine

Full Text:

PDF

References


Butler MS, Blaskovich MA, Cooper MA. Antibiotics in the clinical pipeline in 2013. The Journal of antibiotics. 2013;66(10):571-91. Epub 2013/09/05.

Martinez JL, Liu L, Petranovic D, Nielsen J. Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation. Current opinion in biotechnology. 2012;23(6):965-71. Epub 2012/04/17.

van Dijl JM, Hecker M. Bacillus subtilis: from soil bacterium to super-secreting cell factory. Microbial cell factories. 2013;12:3. Epub 2013/01/15.

Waegeman H, Soetaert W. Increasing recombinant protein production in Escherichia coli through metabolic and genetic engineering. Journal of industrial microbiology & biotechnology. 2011;38(12):1891-910. Epub 2011/09/09.

Demain AL, Vaishnav P. Production of recombinant proteins by microbes and higher organisms. Biotechnology advances. 2009;27(3):297-306. Epub 2009/06/09.

Nielsen J. Production of biopharmaceutical proteins by yeast: advances through metabolic engineering. Bioengineered. 2013;4(4):207-11. Epub 2012/11/14.

Barros FF, Simiqueli AP, de Andrade CJ, Pastore GM. Production of Enzymes from Agroindustrial Wastes by Biosurfactant-Producing Strains of Bacillus subtilis. Biotechnology research international. 2013;2013:103960. Epub 2013/03/28.

Bergquist P, Te'o V, Gibbs M, Cziferszky A, de Faria FP, Azevedo M, et al. Expression of xylanase enzymes from thermophilic microorganisms in fungal hosts. Extremophiles : life under extreme conditions. 2002;6(3):177-84. Epub 2002/06/20.

Ren Q, Henes B, Fairhead M, Thony-Meyer L. High level production of tyrosinase in recombinant Escherichia coli. BMC biotechnology. 2013;13:18. Epub 2013/02/28.

Gu J, Codd R. Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of inorganic biochemistry. 2012;115:198-203. Epub 2012/03/01.

Giancarlo Lancini DALD. Bacterial Pharmaceutical Products. The Prokaryotes – Applied Bacteriology and Biotechnology. 2013:257-80.

Gonzalez R, Islas L, Obregon AM, Escalante L, Sanchez S. Gentamicin formation in Micromonospora purpurea: stimulatory effect of ammonium. The Journal of antibiotics. 1995;48(6):479-83. Epub 1995/06/01.

Lee SE, Kim YO, Choi WY, Kang DH, Lee HY, Jung KH. Two-step process using immobilized Saccharomyces cerevisiae and Pichia stipitis for ethanol production from Ulva pertusa Kjellman hydrolysate. Journal of microbiology and biotechnology. 2013;23(10):1434-44. Epub 2013/07/16.

Klein G, Schanstra JP, Hoffmann J, Mischak H, Siwy J, Zimmermann K. Proteomics as a Quality Control Tool of Pharmaceutical Probiotic Bacterial Lysate Products. PloS one. 2013;8(6):e66682. Epub 2013/07/11.

Daugherty PS. Protein engineering with bacterial display. Current opinion in structural biology. 2007;17(4):474-80. Epub 2007/08/31.

Biesebeke RT, Record E. Scientific Advances with Aspergillus Species that Are Used for Food and Biotech Applications. Microbes and environments / JSME. 2008;23(3):177-81. Epub 2008/01/01.

Coates AR, Halls G, Hu Y. Novel classes of antibiotics or more of the same? British journal of pharmacology. 2011;163(1):184-94. Epub 2011/02/18.

Nelson ML, Levy SB. The history of the tetracyclines. Annals of the New York Academy of Sciences. 2011;1241:17-32. Epub 2011/12/24.

Novotna J, Li XM, Vohradsky J, Weiser J. Protein profiles of Streptomyces aureofaciens producing tetracyclines: reappraisal of the effect of benzyl thiocyanate. Current microbiology. 1995;31(2):84-91. Epub 1995/08/01.

Abu-Salah KM. Amphotericin B: an update. British journal of biomedical science. 1996;53(2):122-33. Epub 1996/06/01.

Horbal L, Zaburannyy N, Ostash B, Shulga S, Fedorenko V. Manipulating the regulatory genes for teicoplanin production in Actinoplanes teichomyceticus. World journal of microbiology & biotechnology. 2012;28(5):2095-100. Epub 2012/07/19.

Bolzan AD, Bianchi MS. Genotoxicity of streptozotocin. Mutation research. 2002;512(2-3):121-34. Epub 2002/12/05.

Berdy J. Thoughts and facts about antibiotics: where we are now and where we are heading. The Journal of antibiotics. 2012;65(8):385-95. Epub 2012/04/19.

Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G. Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya. Antimicrobial agents and chemotherapy. 2011;55(4):1638-49. Epub 2011/01/26.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. Journal of natural products. 2007;70(3):461-77. Epub 2007/02/21.

Padma PN, Rao AB, Yadav JS, Reddy G. Optimization of fermentation conditions for production of glycopeptide antibiotic vancomycin by Amycolatopsis orientalis. Applied biochemistry and biotechnology. 2002;102-103(1-6):395-405. Epub 2002/10/25.

Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacological reviews. 2004;56(2):185-229. Epub 2004/06/01.

Li KT, Zhou J, Wei SJ, Cheng X. An optimized industrial fermentation processes for acarbose production by Actinoplanes sp. A56. Bioresource technology. 2012;118:580-3. Epub 2012/06/19.

Demirev AV, Khanal A, Sedai BR, Lim SK, Na MK, Nam DH. The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini. Applied microbiology and biotechnology. 2010;87(3):1129-39. Epub 2010/05/04.

Torres M, Canela R, Riba M, Sanchis V. Production of patulin and griseofulvin by a strain of Penicillium griseofulvum in three different media. Mycopathologia. 1987;99(2):85-9. Epub 1987/08/01.

Heusler K, Pletscher A. The controversial early history of cyclosporin. Swiss medical weekly. 2001;131(21-22):299-302. Epub 2001/10/05.

Strauss ML, Jolly NP, Lambrechts MG, van Rensburg P. Screening for the production of extracellular hydrolytic enzymes by non-Saccharomyces wine yeasts. Journal of applied microbiology. 2001;91(1):182-90. Epub 2001/07/10.

Copetti MV, Iamanaka BT, Mororo RC, Pereira JL, Frisvad JC, Taniwaki MH. The effect of cocoa fermentation and weak organic acids on growth and ochratoxin A production by Aspergillus species. International journal of food microbiology. 2012;155(3):158-64. Epub 2012/02/22.

Zendo T. Screening and characterization of novel bacteriocins from lactic acid bacteria. Bioscience, biotechnology, and biochemistry. 2013;77(5):893-9. Epub 2013/05/08.

Kirk O, Borchert TV, Fuglsang CC. Industrial enzyme applications. Current opinion in biotechnology. 2002;13(4):345-51. Epub 2002/09/27.

Xu B, Han ZB, Yang P, Liu YJ, Li YH, Han ZC. [High expression of mirobial transglutaminase gene from Streptoverticillium mobaraense in Escherichia coli]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2005;21(5):794-8. Epub 2005/11/16.

Chary VK, de la Fuente JL, Leitao AL, Liras P, Martin JF. Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up to two-fold increase in cephamycin C production. Applied microbiology and biotechnology. 2000;53(3):282-8. Epub 2000/04/20.

Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, et al. Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus. Molecular microbiology. 2011;81(4):968-81. Epub 2011/06/24.

Asmana Ningrum R. Human Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment. Scientifica. 2014;2014:970315. Epub 2014/04/18.

Morowvat MH, Babaeipour V, Rajabi-Memari H, Vahidi H, Maghsoudi N. Overexpression of Recombinant Human Beta Interferon (rhINF-beta) in Periplasmic Space of Escherichia coli. Iranian journal of pharmaceutical research : IJPR. 2014;13(Suppl):151-60. Epub 2014/04/09.

Rezaei M, Zarkesh-Esfahani SH. Optimization of production of recombinant human growth hormone in Escherichia coli. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2012;17(7):681-5. Epub 2013/06/27.

Junqueira-Kipnis AP, Marques Neto LM, Kipnis A. Role of Fused Immunogens and Adjuvants in Modern Tuberculosis Vaccines. Frontiers in immunology. 2014;5:188. Epub 2014/05/06.

Tangney M, van Pijkeren JP, Gahan CG. The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy. Bioengineered bugs. 2010;1(4):284-7. Epub 2011/02/18.

Ferrer-Miralles N, Domingo-Espin J, Corchero JL, Vazquez E, Villaverde A. Microbial factories for recombinant pharmaceuticals. Microbial cell factories. 2009;8:17. Epub 2009/03/26.

Zwick F, Lale R, Valla S. Strong stimulation of recombinant protein production in Escherichia coli by combining stimulatory control elements in an expression cassette. Microbial cell factories. 2012;11:133. Epub 2012/10/04.

Schallmey M, Singh A, Ward OP. Developments in the use of Bacillus species for industrial production. Canadian journal of microbiology. 2004;50(1):1-17. Epub 2004/03/31.

Son YD, Jeong YT, Park SY, Kim JH. Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes. Glycobiology. 2011;21(8):1019-28. Epub 2011/03/26.

Singh BK, Macdonald CA. Drug discovery from uncultivable microorganisms. Drug discovery today. 2010;15(17-18):792-9. Epub 2010/07/27.

Lorenz P, Liebeton K, Niehaus F, Eck J. Screening for novel enzymes for biocatalytic processes: accessing the metagenome as a resource of novel functional sequence space. Current opinion in biotechnology. 2002;13(6):572-7. Epub 2002/12/17.

Singh BK. Exploring microbial diversity for biotechnology: the way forward. Trends in biotechnology. 2010;28(3):111-6. Epub 2009/12/17.

Pracht M, Herrera F, Tawadros T, Berthold D. [Immunotherapy: a therapeutic revolution against prostate cancer?]. Revue medicale suisse. 2013;9(387):1070-5. Epub 2013/06/14. Immunotherapie: une nouvelle arme contre le cancer de la prostate.




DOI: http://dx.doi.org/10.1111%2Ftips.v1i2.25

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Contact Information:
  • Trends in Pharmaceutical Sciences, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR, Iran.
    Tel/Fax: +98 71 32424128 Ext: 297
  • P.O. Box: 17345-1583 Shiraz, Iran
  • Web site: tips.sums.ac.ir
    Email:tips@sums.ac.ir; irantips@gmail.com 
  • pISSN: 2423-3722   eISSN: 2423-5652