@article { author = {Hemmati, Shiva}, title = {A Tribute to Professor Maike Petersen}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {231-232}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2020.88890.1071}, abstract = {Maike Petersen as a professor of pharmaceutical biology at Marburg University has been admired on the occasion of her 62nd birthday. Her scientific trend, mesmerizing character, discipline, and good nature make her a role model for the generation of students and colleagues. Her behavior can profoundly influence the thoughts on scholarship, leadership, and humanity. A rare combination of a personality trait with simultaneous brilliance and humbleness makes her so respected. In addition to all the marvelous attributes of her personality, her reputation as a phytochemist is truly deserved. A brief review of her achievements shows that she is one of the pioneers in the identification and characterization of enzymes, especially in vitro plant cultures, to shed light on the biosynthetic pathways in the way of the production of valuable metabolites. Trends of her research show her focused and oriented investigations in the field. Therefore, within this letter, her commitment to innovation, pluralism, generosity of spirit with all due respect has been admired.}, keywords = {Professor Maike Petersen,Legacy,Phytochemistry}, url = {https://tips.sums.ac.ir/article_47133.html}, eprint = {https://tips.sums.ac.ir/article_47133_3a7d2131ffdf2449c7c0ed48293c0daa.pdf} } @article { author = {Iraji, Aida and Nemati, Ali and Hosseinpoor, Hona and Edraki, Najmeh and Khoshneviszadeh, mahsima and Attarroshan, Mahshid and Sadeghpour, Hossein and Khoshneviszadeh, Mehdi}, title = {Novel heterocyclic hybrid of 2-(aryl)-1H-indene-1,3(2H)-dione targeting tyrosinase: design, biological evaluation and in silico studies}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {233-242}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2020.88203.1068}, abstract = {Melanogenesis is a process of melanin synthesize, which is a primary response for the pigmentation of human skin. Tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin formation, natural products have shown potent inhibitors, but some of these possess toxicity. Numerous synthetic inhibitors have been developed in recent years may lead to the potent anti-tyrosinase agents. Therefore its inhibition may be an efficient way for the development of depigmenting agents. A novel series of 2-arylidine-1H-indene-1,3(2H)-dione analogs were designed, synthesized and screened for their in vitro tyrosinase inhibitory activity. 3d derivative bearing nitrothiophene revealed excellent anti-tyrosinase activity with an IC50 value of 3.55 μM comparable to kojic acid as a positive control. 3d as the most potent inhibitor and 3f as the least active derivative were subjected to in silico evaluations considering the 3D conformations, ΔGb of bindings and interactions within the active site of tyrosinase. }, keywords = {1,3-Indandione,Tyrosinase inhibitor,In silico studies,organic Synthesis}, url = {https://tips.sums.ac.ir/article_47117.html}, eprint = {https://tips.sums.ac.ir/article_47117_413de650c0a9c47dd1647abf45d85727.pdf} } @article { author = {Heidari, Reza and Raeisi, Akbar and Pasdaran, Ardalan and Hamedi, Azadeh}, title = {Investigation of Chemical Composition of Oriental plane (Platanus orientalis L.) Hydrosol and its Effects on Tissue Damage Markers and Plasma Enzymes in Short-term Consumption}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {243-254}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2020.88485.1069}, abstract = {Oriental plane hydrosol (distillate), as a remedy for weight gain and asthma treatment is popular in ethnomedicine. Phytochemicals of medicinal plants could have side effects or serious damages. In this study, the oriental plane hydrosol was prepared by steam distillation. Also, tree oriental plane hydrosol samples from different companies were purchased from herbal market to compare the constituents. The phytochemicals in hexane and chloroform extracts of the hydrosols were identified by GC-MS analysis. In order to investigate subacute toxicity, the hydrosol was given to groups of 6 of male mice at doses of 10, 50, 100, 300 or 500 µl/ mouse/ twice a day by gavage for 14 consecutive days (subacute toxicity) or just for one day (acute toxicity). Serologic and pathologic samples were prepared. Chloroform extracts contained mostly (Z) -3-hexenol, thymol, carvacrol, camphor and the main constituents of hexane extracts include decane, dodecane and hexadecane. The results showed lack of serologic toxicity in subacute consumption of the hydrosol. In acute toxicity study, the levels of ALT, LDH, and BUN increased significantly. Other enzymes did not change significantly in compare to the control group. No significant pathologic damage was seen in heart or lung tissues, but the liver and kidney showed mild inflammation in acute toxicity study and inflammation in subacute toxicity studies. Determination of compounds which are responsible for the observed effects and especially safety of this hydrosol consumption for the longer periods can prevent side effects or possible toxicities.}, keywords = {Aromatic water,Oriental Plane Distillate,Platanus orientalis,Toxicity}, url = {https://tips.sums.ac.ir/article_47132.html}, eprint = {https://tips.sums.ac.ir/article_47132_24c2bcbddb1384865ee0ead59c17f612.pdf} } @article { author = {Azadi, Roza and Musavi, Seyyedeh Elaheh and Motekef, Negar and Rezayat, Seyed Mehdi and Jafari, Mahmoudreza}, title = {Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {255-262}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2021.88569.1070}, abstract = {Berberine (BBR) is a quaternary ammonium salt that possesses plentiful therapeutics properties. But notwithstanding the positive points, it has two negative points: poor aqueous solubility and permeability. These properties are important for achieving good bioavailability and therapeutic effect. Lately nano formulations developed to overcome these challenges through drug encapsulation. The aim of this study was preparation of nano formulations based on surfactant to achieve the best formulation with good characteristics. In this research, nano micellar formulations were prepared by thin film hydration method using poly sorbate 20 as surfactant and BBR as drug to get the good formulation based on high encapsulation efficiency (EE). Then nano micelles were characterized by particle size and polydispersity index (PDI) by DLS, drug encapsulation by UV-Vis spectrophotometer and drug release behavior in simulated gastro fluid (SGF) and simulated intestinal fluid (SIF). BBR successfully was encapsulated within micelles by thin film hydration method. DLS analysis showed average size of nano micelle samples between 9.247 and 18.46 nm, PDI was about 0.271, with maximum percentage of drug encapsulation of 78%. Also fluctuation of drug release was very low in elementary time points in SGF and SIF, and it was approximately sustained release profile. These results showed to achieve a good formulation and in order to have better drug delivery, physical attributes including the size distribution, PDI, and EE should be controlled. Our findings may be benefactress for different applications in variety research fields of pharmaceutical industry. }, keywords = {berberine,nano formulation,Drug delivery,encapsulation,micelle}, url = {https://tips.sums.ac.ir/article_47269.html}, eprint = {https://tips.sums.ac.ir/article_47269_f453977f63c9690de8e4341116ee2f33.pdf} } @article { author = {Adikwu, Elias and Ebinyo, Nelson and Clara Adogbo Ejovwoke, Clara}, title = {Resveratrol abrogates 5-flourouracil -induced hepatotoxicity: A preclinical study}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {263-270}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2021.87868.1065}, abstract = {The manifestation of acute hepatotoxicity caused by 5-fluorouracil could be characterized by asymptomatic elevations of liver enzymes, hepatic steatosis and fuminant hepatitis. Natural antioxidants have potential as excellent treatment strategy against diseases and drug-induced toxicities. This study assessed the potential of resveratrol (RSV) to abrogate the hepatotoxic effect of 5-FU in rats. Forty adult male albino rats (240g± 20g) were randomized and orally supplemented with RSV (10, 20 and 40 mg/kg/day) prior to the administration of 5-FU (20mg/kg/day) intraperitoneally for 5 days. On day 6, after weighing, the rats were anesthetized, blood samples were collected and centrifuged and sera obtianed. Liver tissues were harvested and weighed. Sera and liver samples were evaluated for biochemical parameters. Liver tissues were assessed for histology. Body weight was significantly (p <0.05) decreased where as liver weight was significantly (p <0.01) increased in 5-FU administered rats in relation to control. Serum and liver lactate dehydrogenase, aminotransferases (AST), alkaline phosphatase, gamma-glutamyl transferase, total bilirubin, conjugated bilirubin and malondialdehyde levels were significantly (p <0.001) increased in 5FU-administered rats in relation to control. Liver glutathione peroxidase, catalase, glutathione and superoxide dismutase levels were significantly (p <0.001) decreased in 5-FU administered rats in relation to control. The liver of 5-FU administered rats showed necrosis and steatosis. The hepatotoxic effect of 5-FU was abrogated in a dose-related fashion in RSV 10 mg/kg (p <0.05), 20mg/kg (p <0.01), and RSV 40mg/kg (p <0.001) supplemented rats in relation to 5-FU. RVS may be clinically effective against 5-FU-induced hepatotoxicity.}, keywords = {5-Fluoroural,Liver,Toxicity,Resveratrol,Mitigation,Rat}, url = {https://tips.sums.ac.ir/article_47251.html}, eprint = {https://tips.sums.ac.ir/article_47251_7d188cfa203978a9d510db6fb450362f.pdf} } @article { author = {Odeghe, Bensandy and Adikwu, Elias and John, Frances}, title = {Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {271-278}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2020.87005.1054}, abstract = {Challenges including treatment failure, cost, resistance, and adverse effects associated with antimalarial drugs have increased the use of medical plants as alternative treatment. Anchomanes difformis (A. difformis) is a multipurpose plant used traditionally for the treatment of a variety of ailments including malaria, but with a paucity of scientific evidence. This study assessed the antiplasmodial activity of A. difformis aqueous leaf extract (AEA) in Plasmodium berghei (P. berghei) infected mice. AEA (100, 200 and 400 mg/kg) was orally administered to P. berghei infected mice in the curative, suppressive and prophylactic groups. The untreated parasitized control (UPC) and the positive control were administered orally with normal saline (0.2mL) and chloroquine (CQ) (10mg/kg). After treatment, blood samples were analyzed for parasitamia level, hematological parameters and liver samples were evaluated for histology. Curative, suppressive and prophylactic studies showed that administered AEA decreased parasitamia levels and increased survival time in a dose-dependent fashion with significance at 200 mg/kg (p}, keywords = {Anchomanes difformis,Antimalaria,Hematology,Liver,mice}, url = {https://tips.sums.ac.ir/article_46877.html}, eprint = {https://tips.sums.ac.ir/article_46877_e01be9d9a0b0e61ea4a3c652a40b6b21.pdf} } @article { author = {Keikha, Masoud}, title = {The association between Helicobacter pylori eradication in peptic ulcer patients and gastric cancer? Investigation in an East-Asian population}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {279-282}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2021.89405.1074}, abstract = {H. pylori is Gram-negative, microaerophilic, and motile bacteria which colonized in human stomach of nearly 50% of world population; there are several evidence for chronic colonization with H. pylori that significantly increased the risk of gastric cancer development (15). Eradication of H. pylori infection can have reduced the risk of gastric cancer as well as reduction of H. pylori in young population as reservoir of infection (5,10). According to literatures, the mother to child transmission is predominant rout of H. pylori transmission in Japanese population; therefore, eradication of H. pylori infection can be considered as appropriated strategy for reducing both of gastric cancer as well as H. pylori infection burden (16). There are several literatures in relation to efficacy of H. pylori eradication for prevention of gastric cancer development in asymptomatic carrier and patients with endoscopic resections (7,8); however, we evaluated the efficacy of H. pylori eradication in reduction of gastric cancer in patients with history of peptic ulcer. We are suggested that H. pylori infection should be eradicated in peptic ulcer patients in order to reducing the risk of develop to gastric cancer.}, keywords = {Helicobacter pylori,peptic ulcer,Gastric Cancer,Asia,Meta-analysis}, url = {https://tips.sums.ac.ir/article_47253.html}, eprint = {https://tips.sums.ac.ir/article_47253_70a10d04fab8c9b32b586c49176fcff6.pdf} } @article { author = {Karamikhah, Raziyeh and Karimzadeh, Iman}, title = {Acute lymphoblastic leukemia in children: A short review}, journal = {Trends in Pharmaceutical Sciences}, volume = {6}, number = {4}, pages = {283-296}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2423-3722}, eissn = {2423-5652}, doi = {10.30476/tips.2021.88938.1073}, abstract = {Acute lymphoblastic leukemia is as the most common childhood cancer. The definite etiology of childhood ALL is unknown. The pathogenesis of ALL is described as the disruption of lymphocyte proliferation and differentiation. The most common signs and symptoms of ALL are fever, hepatosplenomegaly, lymphadenopathy, pallor, and bleeding. Diagnosis is based on conducting complete blood cell, peripheral blood smear, bone marrow aspirate, immunophenotype, and cytogenetics tests. A number of demographic, clinical, and paraclinical characteristics of patients have been determined as prognostic factors. To select the appropriate treatment protocol, patients are risk stratified. In induction therapy, vincristine, corticosteroid, and asparaginase are given for the low- and standard risk groups and a four-drug induction therapy including vincristine, corticosteroid, asparaginase, and anthracycline are given for high- and very high-risk group for B cell ALL. The induction phase follow with post-induction courses including consolidation, interim maintenance, delayed intensification, and maintenance phases. ALL in pediatrics has a good prognosis and high cure rate.}, keywords = {Acute Lymphoblastic Leukemia,children,Epidemiology,Etiology,Treatment}, url = {https://tips.sums.ac.ir/article_47252.html}, eprint = {https://tips.sums.ac.ir/article_47252_96fdfb17fe978b3ba431fe07bf540356.pdf} }