ORIGINAL_ARTICLE
Cell organelle-shaped liposomes: A novel approach to present the stable intracellular drug delivery systems
Caveolae are lipid raft-enriched flask-shaped, expose in the plasma membrane of various cell types. It has become clear now that caveolae and their caveolin “marker proteins” are associated in a several cellular procedures including endocytosis, lipid homeostasis, signal transduction, and tumorigenesis. Caveolin has been shown to have high binding affinity for cholesterol and sphingolipids. Caveolin oligomers construct filamentous networks that are believed to stabilize the membrane. Liposomes are the well-known drug delivery systems with spherical shape that can be produced from natural non-toxic phospholipids and cholesterol. Liposomes have been used as a considerable tool in biology, biochemistry, medicine, and drug delivery. The utilization of liposomes as a drug-delivery system has become more attractive in carrying systemically administered drugs with narrow therapeutic windows. The similarity between plasma membrane and liposomes from several points of view gives hope that the incorporation of caveolin in the phospholipid bilayer structures of liposomes can result in tightening and therefore stabilizing and long circulation of these structures.
https://tips.sums.ac.ir/article_42187_028b1dff8f680a0855dd3a068991cec7.pdf
2016-06-01
Amir
Azadi
amirazadipharm@gmail.com
1
AUTHOR
Hajar
Ashrafi
hashrafi@sums.ac.ir
2
Department of Pharmaceutics, School of Pharmacy, International branch, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Medicinal Plants for Joint Pain in Traditional Persian Medicine
Joint pains can be resulted by many factors of which osteoarthritis (OA) and rheumatoid arthritis (RA) are the most popular ones. Treatment of both conditions usually involves pain killers. Chronic joint pains are associated with a high usage of herbal medicines. Herbal remedies are the main part of many traditional medical schools specially Traditional Persian Medicine. This study is conducted to present herbal remedies for joint pain from important treatises of Traditional Persian Medicine. Five manuscripts of the most comprehensive pharmacopeias in TPM which cover more than 900 years of golden ages and also commonly used by natural healers were used. Totally more than 120 medicinal herbs were mentioned for joint pain in those treatises, but 105 herbs from 59 different families were identified. This list of traditional herbal medicines, some of which were used for 1000 years for joint pain, this perennial problem, can provide a basis for further studies and therefore finding more effective drugs to help solving more problems in this area.
https://tips.sums.ac.ir/article_42189_8c50275e0d470b4dbf08d79fc6473799.pdf
2016-06-01
Joint pain
Traditional Persian Medicine
Herbal
Zohreh
Abolhassanzadeh
abolhasan@sums.ac.ir
1
Pharmaceutical Science Research Center, School of Pharmacy. Shiraz University of Medical Sciences, Shiraz, IR Iran.
AUTHOR
Elham
Aflaki
2
Department of Internal Medicine, School of Medicine, School of Pharmacy. Shiraz University of Medical Sciences, Shiraz, IR Iran.
AUTHOR
Gholamhossein
Yousefi
3
Department of Pharmaceutics, School of Pharmacy, School of Pharmacy. Shiraz University of Medical Sciences, Shiraz, IR Iran.
AUTHOR
Abdolali
Mohagheghzadeh
mohaghegh@sums.ac.ir
4
Department of Phytopharmaceuticals (Traditional Pharmacy) , School of Pharmacy. Shiraz University of Medical Sciences, Shiraz, IR Iran.
LEAD_AUTHOR
Wambugua S. N., Mathiua P. M., Gakuyab D. W., Kanuia T. I., Kabasac J. D., G. KS. Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya. Journal of Ethnopharmacology. 2011;137:945- 55.
1
Parmet S LC, Glass RM. Osteoarthritis of the Knee. J Am Med Assoc. 2003;289(8):1068.
2
Arden N. Osteoarthritis: Epidemiology. Best Practice & Research Clinical Rheumatology. 2006;20(1):3-25.
3
Hugh A., Gemmell, Bert H., Jacobson, Brad M., Hayes. Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot srudy. ournal of manipulative and physiological therapeutics. 2003;26(5).
4
Gabriel S. E. The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am. 2001;27(2):269-81.
5
Alarcon G. Epidemiology of rheumatoid arthritis. Rheumatic Diseases Clinics of North America. 1995;21:589-604.
6
Stanos S. P. Topical Agents for the Management of Musculoskeletal Pain. Journal of Pain and Symptom Management. 2007;33( 3):342-55.
7
Argoff C. E. Topical Analgesics in the Management of Acute and Chronic Pain. Mayo Clinic Proceedings. 2013;88(2):195-20.
8
Astin J. A. Why patients use alternative medicine:Results of a national study. JAMA. 1998; 279:1548-53.
9
Resch L., Hill S., Ernest E. Use of complementary therapies by individuals with arthritis. Clinical Rheumatology. 1997;16:391-5.
10
Setty A., Sigal L. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy and side effects. Seminars in Arthritis and Rheumatism. 2005;34:773-84.
11
Adams M., Berset C., Kessler M., Hamburger M. Medicinal herbs for the treatment of rheumatic disorders-A survey of European herbals from the 16th and 17th century. Journal of Ethnopharmacology. 2009;121(3):343-59.
12
Al-rhazes (Rhazes) M., editor. Al Havi (Liber Continent). Tehran: Academy of Medical Sciences Publication; 2005.
13
Avicenna., editor. Canon Fi Tibb (Canon of Medicine). New Delhi: Jamia Hamdard Printing Press; 1988.
14
Heravi A. M. Alabnie an Haghaegh ol Advieh. Tehran Iran: Tehran University Press; 1992.
15
Ansari Shirazi Z. A. Ekhtiyarat-e-Badiyee. Mir rbMT, editor. Tehran: Pakhsh Razi Press; 1992.
16
Aghili Shirazi S.M.H.I.M.H. Makhzan ol Advieh. Tehran: Intisharat va Amoozesh enghelab Islami Press; 1992.
17
Biruni A. R. Seydaneh fi Teb. Mozaffarzadeh PtbB, editor. Tehran: Iranian Academy of Persian Language and Literature Press; 2004.
18
Hooper D., Field H. Useful plants and drugs of Iran and Iraq. Chicago: Field Museum of Natural History; 1937.
19
Dymook W., Warden C. J., Hooper D. Pharmacographica Indica. London: Kegan Paul;; 1893.
20
Muthuraman A., Singh N., Singh Jaggi A. Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: An evidence of anti-inflammatory and anti-oxidative activity. Food and Chemical Toxicology. 2011;49(10):2557-63.
21
Almeida R.N., Almeida R.N., Navarro D.S., Barbosa-Filho J.M. Plants with central analgesic activity. Phytomedicine. 2001;8(4):310-22.
22
Garg V. R., Jain M., Sharma P. K., Garg G. Anti-infl ammatory activity of spinacia oleracea. Int J Pharma Prof Res. 2010;1:1-4.
23
Atta A. H., Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol 1998;60:117-24.
24
Ãakici I., Ulug H. Y., Inci S., Tunçtan B., Abacioglu N., Kanzik I., et al. Antinociceptive effect of some Amaryllidaceae plants in mice. J Pharm Pharmacol. 1997;49:828-30.
25
Maxia A., Sanna C., Frau M. A., Piras A., Karchuli M. S., Kasture V. Anti-inflammatory activity of Pistacia lentiscus essential oil: involvement of IL-6 and TNF-alpha. Nat Prod Commun. 2011;6(10):1543-4.
26
Mahmoudi M., Ebrahimzadeh M. A., Nabavi S. F., Hafezi S., Nabavi S. M., Eslami Sh. Antiinflammatory and antioxidant activities of gum mastic. Eur Rev Med Pharmacol Sci. 2010;14:765-9
27
El-Sawy E.R., Ebaid M.S., Abo-Salem H.M., Al-Sehemi A.G., Mandour A.H. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of some new 4,6-dimethoxy-5-(heterocycles)benzofuran starting from naturally occurring visnagin. Arabian Journal of Chemistry. In Press.
28
Naseri M., Mojab F., Khodadoost M., Kamalinejad M., Davati A., Choopani R., et al. The Study of Anti-Inflammatory Activity of Oil-Based Dilln(Anethum graveolens L.) Extract Used Topically innFormalin-Induced Inflammation Male Rat Paw
29
Iranian Journal of Pharmaceutical Research. 2012;11(4):1169-74.
30
Bakhtiarian A., Rezai-Asl M., Sabour M., Nikoui V., Ghamami G., Yadavar-Nikravesh M. S., et al. The study of analgesic effects of hydroalcoholic extract of seed and crops of Anethum graveolens. Toxicology Letters. 2012;211.
31
Iranshahy M., Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafetida (Ferula assa-foetida oleo-gum-resin). Journal of Ethnopharmacology. 2011;134:1-10.
32
Shahverdi A.R., Saadat F., Khorramizadeh M. R., Iranshahi M., Khoshayand M. R. Two matrix metalloproteinases inhibitors from Ferula persica var. persica. Phytomedicine. 2006;13:712-7.
33
Erdemoglu N., Küpeli E., YeÅilada E. Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J Ethnopharmacol 2003;89:123-9.
34
Bae E. A., Yoo Y. I., Lee I. A., Joo Han M., Kim D. H. The anti-inflammmatory effect of fermented red ginseng in experimental colitic mice. Food Agr Immunol. 2008;19:313-23.
35
Choi S. S., Han E. J., Han K. J., Lee H. K., Suh H. W. Antinociceptive Effects of Ginsenosides Injected Intracerebroventricularly or Intrathecally in Substance P-Induced Pain Model. Planta Med. 2003;69:1001-4.
36
Fayyaz A., Rafeeq A. K., Ibrahim H. Study of analgesic and antiinflammatory activity from plant extracts of lactuca scarriola and artemisia absinthium. J Islam Acad Sci. 1992;5:111-4.
37
Núñez Figueredo Y., Montero Alarcon C., Agüero Fernandez S., Muñoz Cernuda A. Preclinical anti-inflammatory effects of dry powder of Calendula officinalis. Efecto antiinflamatorio preclinico del polvo seco de Calendula officinalis. Lat Am J Pharm. 2007;26:548-52.
38
Ahmad S., Qureshi S., Atiqur R., Zakirur R., Badar Y. Antipyretic and analgesic activity in crude ethanolic extract of Calendula officinalis Linn. Pak J Sci Ind Res. 2000;43:50-4.
39
Cavin C., Delannoy M., Malnoe A., Debefve E., Touche A., Courtois D., et al. Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract. Biochem Biophys Res Commun. 2005;327:742-9.
40
Wesolowska A., Nikiforuk A., Michalska K., Kisiel W., Chojnacka-Wojcik E. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. J Ethnopharmacol. 2006;107:254-8.
41
Wu Y., Xu Y., Yao L. Anti-inflammatory and Anti-allergic Effects of German Chamomile (Matricaria chamomilla L.). Journal of Essential Oil Bearing Plants. 2011;14(5).
42
Heidari M. R., Asadipour A., Ghayoor. Evaluation of Analgesic and Ulcerogenic Effects of Methanolic Extract of Matricaria chamomilla L. J Qazvin Univ Med Sci. 2003;20:15-23.
43
Bonjardim L. R., da Silva A. P., Gameiro G. H., Tambeli C. H., Ferraz de Arruda Veiga M. C. Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic. Pharmacol Biochem Behav. 2009;91:321-6.
44
Lin J. Y., Li C.Y., Hwang I. F. Characterisation of the pigment components in red cabbage (Brassica oleracea L. var.) juice and their anti-inflammatory effects on LPS-stimulated murine splenocytes. Food Chem. 2008;109:771-81.
45
Su Sh., Hua Y., Wang Y., Gu W., Zhou W., Duan J., et al. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. Journal of Ethnopharmacology. 2012;139(2):649-56.
46
Tipton D. A., Lyle B., Babich H., Dabbous M. In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicol In Vitro. 2003;17:301-10.
47
al-Said M. S., Abdelsattar E. A., Khalifa S. I., el-Feraly F. S. Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Pharmazie. 1988;43:640-1.
48
Panico A. M., Cardile V., Garufi F., Puglia C., Bonina F., Ronsisvalle G. Protective effect of Capparis spinosa on chondrocytes. Life Sci. 2005;77:2479-88.
49
Sireeratawong S., Jaijoy K., Panunto W., Soonthornchareonnon N. Anti-inflammatory activity and toxicity of the water extract of Terminalia chebula rezt in rats. Planta Med. 2012; 78 112.
50
Kaur S., Jaggi R. K. Antinociceptive activity of chronic administration of different extracts of Terminalia bellerica Roxb. and Terminalia chebula Retz. fruits. Indian J Exp Biol. 2010;48:925-30.
51
Blazovics A., Lugasi A., Szentmihalyi K., Kery Ã. Reducing power of the natural polyphenols of Sempervivum tectorum in vitro and in vivo. Act Biol Szeg. 2003;47:99-102.
52
Kekesi G., Dobos I., Benedek G., Horvath G. Antinociceptive Activity of Sempervivum tectorum L. Extract in Rats. Phytother Res. 2003;17:1032-6.
53
Yesilada E., Tanaka S., Sezik E., Tabata M. Isolation of an anti-inflammatory principle from the fruit juice of Ecballium elaterium. J Nat Prod. 1988;51:504-8.
54
Agil M. A., Risco S., Miro M., Navarro M. C., Ocete M. A., Jimenez J. Analgesic and antipyretic effects of Ecballium elaterium (L.) A. Richard. Extract in rodents. Phytother Res. 1995;9(135-138).
55
Marzouk B., Marzouk Z., Haloui E., Fenina N., Bouraoui A., Aouni M. Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J Ethnopharmacol. 2010;128:15-9.
56
Ahmadiani A., Hosseiny J., Semnanian S., Javan M., Saeedi F., Kamalinejad M., et al. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. J Ethnopharmacol. 2000; 72:287-92.
57
Ilavarasan R., Mallika M., Venkataraman S. Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. J Ethnopharmacol. 2006;103:478-80.
58
Vieira C., Fetzer S., Sauer S. K., Evangelista S., Averbeck B., Kress M., et al. Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin. Naunyn Schmiedebergs Arch Pharmacol. 2001;364:87-95.
59
Shaker E., Mahmoud H., Mnaa S. Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). Food and Chemical Toxicology. 2010;48(10):2785-90.
60
Bhakta T., Mukherjee P. K., Saha K., Pal M., Saha B. P., Mandal S. C. Evaluation of anti-inflammatory effects of Cassia fistula (Leguminosae) leaf extract on rats. Journal of Herbs , Spices and Medicinal Plants. 1999;6:67-72.
61
Patwardhan S., Sakhare G., Singhai A. K., Jain K., Somani R. Evaluation of analgesic activity of Cassia fistula on albino mice. Pharmacologyonline. 2009;2:887-93
62
Saravana Kumar A., Gandhimathi R., Mohana Lakshmi S., Rahul N., Ashok Kumar C. K. Evaluation of the antinociceptive properties from Indigofera tinctoria leaves extracts. J Pharm Sci & Res. 2009;1:31-7.
63
Berkan T., Ustünes L., Lermioglu F., Ozer A. Antiinflammatory, analgesic, and antipyretic effects of an aqueous extract of Erythraea centaurium. Planta Med. 1991;57:34-7.
64
Papoutsi Z., Kassi E., Chinou ., Halabalaki M., Skaltsounis L. A., Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr. 2008;99:715-22.
65
Lin J.T., Chen Y. C., Lee Y. C., Rolis Hou C. W., Chen F. L., Yang D. J. Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm (Melissa officinalis L.) leaves. Food Science and Technology. 2012;49(1):1-7.
66
Guginski G., Luiz A. P., Silva M. D., Massaro M., Martins D. F., Chaves J., et al. Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. Pharmacology Biochemistry and Behavior. 2009;93(1):10-6.
67
Tariq M., Ageel A. M., al-Yahya M. A., Mossa J. S., al-Said M. S. Anti-inflammatory activity of Teucrium polium. Int J Tissue React. 1989;11(4):185-8.
68
Baluchnejadmojarad T., Roghani M., Roghani-Dehkordi F. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J Ethnopharmacol. 2005;97:207-10.
69
Hosseinzadeh H., Ramezani M., Salman G. A. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. Journal of Ethnopharmacology. 2000;73( 3):379-85.
70
Sayyah M., Saroukhani G., Peirovi A., Kamalinejad M. Analgesic and anti-infl ammatory activity of the leaf essential oil of Laurus nobilis Linn. Phytother Res. 2003;17:733-6.
71
Deraniyagala S.A, Ratnasooriya W.D, Goonasekara C.L. Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats. Journal of Ethnopharmacology. 2003;86(1):21-6.
72
Hodge G., Hodge S., Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry. 2002;48:209-15.
73
Hyun S. H., Kim M. B., Lim S. B. Physiological activities of garlic extracts from Daejeong Jeju and major cultivating areas in Korea. Journal of the Korean Society of Food Science and Nutrition. 2008;37:1542-7.
74
Chandrasekaran A. N., Porkodi R. Thiocolchicoside an anti-infl ammatory analgesic agent with muscle relaxant action. J Indian Rheum Assoc. 1994;2:137-9.
75
Vazquez B., Avila G., Segura D., Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. Journal of Ethnopharmacology. 1996; 55(1):69-75.
76
Shahraki M. R., Mirshikari H. The Anti-Nociceptive effect of Aloe vera aqueous extract in fructose-fed male rats. Basic Clin Neurosci 2010;1:39-43.
77
Dupasquier C. M., Dibrov E., Kneesh A. L., Cheung P. K., Lee K. G., Alexander H. K., et al. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Am J Physiol Heart Circ Physiol. 2007;293:2394-402.
78
Ahmad F., Khan R. A., Rashid S. Pharmacological evaluation of medicinal plants for their analgesic activity in mice. Med J Islam Repub Iran. 1996;10:149-52.
79
Chen J., Wang X., Qu Y., Chen Zh., Cai H., Liu X., et al. Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: Effect of changes in alkaloid composition. Journal of Ethnopharmacology. 2012;139(1):181-8.
80
Ali B. H., Bashir A. K., Tanira M. O. Anti-infl ammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats. Pharmacology Biochemistry and Behavior. 1995;51:356-63.
81
Koley K.M., Lal J., Tandan S.K. Anti-inflammatory activity of Azadirachta indica (neem) leaves. Fitoterapia. 1994;65:524-8.
82
Patel J. P., Hemavathi K. G., Bhatt J. D. Study of the antinociceptive effect of neem leaf extract and its interaction with morphine in mice. Indian J Pharmacol. 2005;37:37-8.
83
Ali H., Monga J., Gupta L., Singh A., Narayan S., Siddiqui Z. A., et al. Anti-inflammatory effects of hydro-methanolic extract of Ficus carica. Biomedical and Pharmacology Journal
84
; 2:129-32.
85
Hosseinzadeh H., Khoshdel M., Ghorbani M. Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice. Journal of Acupuncture and Meridian Studies. 2011;4(4):242-7.
86
Süntar I., Tumen I., Ustün O., KeleŠH., Küpeli Akko E. Appraisal on the wound healing and anti-inflammatory activities of the essential oils obtained from the cones and needles of Pinus species by in vivo and in vitro experimental models. Journal of Ethnopharmacology.139(2):533-40.
87
Devan P., Bani S., Suri K.A., Satti N.K., Qazi G.N. Immunomodulation exhibited by piperinic acid through suppression of proinflammatory cytokines. Int Immunopharmacol. 2007;7:889-99.
88
Park J.E., Choi H.J., Jung S.H., Kim N.J., Kim D.H. Analgesic and antiinflammatory activities of some oriental herbal medicines. Kor J Pharmacog. 2001;32:257-68.
89
Rodriguez-Cabezas M.E., Galvez J., Camuesco D., Lorente M.D., Concha A., Martinez-Augustin O., et al. Intestinal anti-inflammatory activity of dietary fiber (Plantago ovata seeds) in HLA-B27 transgenic rats. Clin Nutr. 2003;22:463-71.
90
Haider S., Nazreen S., Mahboob Alam M., Hamid H., Sarwar Alam M. Anti-inflammatory and anti-nociceptive activities of Platanus orientalis Linn. and its ulcerogenic risk evaluation. Journal of Ethnopharmacology. 2012;143(1):236-40.
91
Almeida R. N., Navarro D. S., Barbosa-Filho J. M. Plants with central analgesic activity. Phytomedicine. 2001 8(4):310-22.
92
Chehl N., Chipitsyna G., Gong Q., Yeo C. J., Arafat H. A. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford). 2009;11(5):373-81.
93
Bashir M.U., Qureshi H.J. Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice. J Coll Physicians Surg Pak
94
;20:464-7.
95
Shams K. A., Schmidt R. Lipid fraction constituents and evaluation of anti-anaphylactic activity of Prunus mahaleb L. kernels. Afr J Tradit Complement Altern Med. 2007;4:289-93.
96
Rakhshandeh H., Vahdati-Mashhadian N., Dolati K., Hosseini M. Antinociceptive effect of Rosa damascena in mice. J Biol Sci. 2008;8:176-80.
97
Chan Y. Y., Li C. H., Shen Y.C., Wu T. S. Anti-inflammatory principles from the stem and root barks of Citrus medica. Chem Pharm Bull. 2010;58:61-5.
98
Sood S., Bansal S., Muthuraman A., Gill N.S., Bali M. Therapeutic potential of citrus medica L. peel extract in carrageenan induced inflammatory pain in rat. Res J Med Plant. 2009;3:123-33.
99
Sarrell E. M., Mandelberg A., Cohen H. A. Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med. 2001;155:796-9.
100
Sarrell E. M., Cohen H. A., Kahan E. Naturopathic treatment for ear pain in children. Pediatrics. 2003;111:574-9.
101
Wannang N. N., Anuka J. A., Kwanashie H. O., Gyang S. S., Auta A. Analgesic and anti-fl ammatory activities of the aqueous leaf extract of solanum nigrum Linn (solanaceae) in rats. Niger J Pharm Res. 2006;5:74-9.
102
Kaileh M., Berghe W. V., Boone E., Essawi T., Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol. 2007;113:510-6.
103
Sharma M. C., Sharma S., Kohli D. V. Formulation and evaluation of analgesic activity, anti-inflammatory and anti-anxiety activity of using plant extracts. Digest Journal of Nanomaterials and Biostructures. 2010;5:147-51.
104
Schuhbaum H., Bürgermeister J., Paper D. H., Franz G. Anti-inflammatory activity of Zingiber officinale extracts. Pharmaceut Pharmacol Lett. 2000;10:82-5.
105
Black C. D., Herring M. P., Hurley D. J., O'Connor P. J. Ginger (Zingiber officinale) Reduces Muscle Pain Caused by Eccentric Exercise. J Pain. 2010.
106
Farouk L., Laroubi A., Aboufatima R., Benharref A., Chait A. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J Ethnopharmacol. 2008;115:449-54.
107
ORIGINAL_ARTICLE
A Reversed-phase High Performance Liquid Chromatography (HPLC) method for bio-analysis of Methotrexate
Methotrexate (MTX) is a chemotherapeutic agent used in treatment of many disorders including autoimmune diseases and cancers. The availability of a reliable analysis method for drug assay in biological fluids of interest is a prerequisite for all pharmacokinetic studies in humans or animal models. Considering the complex matrices of the biological specimens as well as the low concentrations of the majority of the drugs in biological fluids, the development of an available while sensitive method for the bioanalytical studies is often a challenging issue.For drug assay in aqueous, plasma, animal brain and liver tissue environments in a concentration range of 25-600 ng/ml, a reverse phase high performance liquid chromatography (RP-HPLC) was developed.System suitability tests were indicating a method with acceptable analytic separation efficiency and peak shape proving method’s selectivity. Limit of detection (LOD) and limit of quantification (LOQ) determined to be 10 ng/ml and 25ng/ml, which reflect method sensitivity. Regression analysis showed a linear correlation between area under curve (AUC) of peaks and corresponding MTX concentrations. The within-day and between-day precision and accuracy was both in acceptable ranges. Recovery index of method for median concentration (200 ng/ml) is also about 74%.The developed method was accorded to the acceptable criteria of analytical method validation. The sensitivity of the method in all the tested matrices made the method suitable in terms of detection and quantitation of low concentration samples throughout the study. Also, the assay method had fairly short run-time and lacks any significant interference.
https://tips.sums.ac.ir/article_42188_bdcfdd85dc680af3d95aaa0b246691d7.pdf
2016-06-01
Leila
Pourtalebi Jahromi
1
Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Soliman
Mohammadi-Samani
2
Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Hajar
Ashrafi
hashrafi@sums.ac.ir
3
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. and Department of Pharmaceutics, School of Pharmacy, International branch, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Amir
Azadi
amirazadipharm@gmail.com
4
Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
Methotrxate monograph. In: Galichet LY, editor. Clarke's Analysis of Drugs and Poisons. 3th ed. London: Pharmaceutical Press; 2005.
1
Rider BJ. Methotrexate monograph. In: Dowd FJ, et al., editors. X pharm. Amsterdam: Elsevier Inc.; 2007.
2
Gerstner ER, Batchelor TT. Primary Central Nervous System Lymphoma. In: Norden AD, Reardon DA, Wen PYC, editors. Primary Central Nervous System Tumors; Pathogenesis and Therapy. New York: Humana Press; 2011. p. 333-54.
3
Olson J, Blakeley J, Grossman S, Weingart J, Rashid A, Supko J. Differences in the distribution of methotrexate into high grade gliomas following intravenous administration as monitored by microdialysis, are associated with blood-brain-barrier integrity. ASCO Meeting Abstracts. 2006; 24:1548.
4
Hamidi M, Azadi A, Rafiei P, Ashrafi H. A Pharmacokinetic Overview of Nanotechnology-Based Drug Delivery Systems: An ADME-Oriented Approach. Crit Rev Ther Drug Carr Syst. 2013; 30:435â467
5
Azadi A, Rouini MR, Hamidi M. Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels. Int J Biol Macromol., 2015; 79: 326-335.
6
Azadi A, Hamidi M, Rouini M-R. Methotrexate-loaded chitosan nanogels as âTrojan Horsesâ for drug delivery to brain: Preparation and in vitro/in vivo characterization. Int J Biol Macromol. 2013; 62:523-30.
7
Azadi A, Hamidi M, Khoshayand MR, Amini M, Rouini MR. Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery. Carbohydr Polym. 2012;90:462-471.
8
United States Pharmacopoeia. 25th ed. Micromedex; 2005.
9
Sadray S, Rezaee S, Rezakhah S. Non-linear heteroscedastic regression model for determination of methotrexate in human plasma by high-performance liquid chromatography. J Chromatogr B. 2003; 787: 293-302.
10
Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER). 2001.
11
ORIGINAL_ARTICLE
Medication errors in Pediatric Intensive Care Unit: incidence, types and outcome
Medication Errors (MEs) play a significant role in mortality and morbidity of hospitalized patients. Therefore, it seems advisable to determine types and consequences of such errors when addressing patient safety. The aim of this study was to determine the incidence, types, outcomes of errors in a 10 bed pediatric Intensive Care Unit at a large teaching hospital from September 2013 to February 2014 in southern Iran.The occurrence of errors was detected with direct observation method. A trained pharmacist selected 41 patients randomly in forty one working shifts. No patient arrived the study twice. In each shift, patient’s medications were observed from prescription, administration, transcription, and dispensing. The pharmacist would intervene only if the ME could cause substantial harms to a patient. All data were reviewed by a clinical pharmacist and a pediatric intensivist to confirm the type of the errors.Of the 512 drug dosages observed, 48.8 errors/100 orders were detected, Administration errors occurred on 148 occasions, with 28.9 chances to occur in each 100 orders. Prescription, transcription and dispensing errors came next with 14.25, 4.88 and 0.78 chance in each 100 orders, respectively. Wrong time, wrong technique, and wrong preparation were among the commonest types of administration errors with 14.1%, 5.7% and 4.9%, respectively. Monitoring errors group with 11.3% was the most common type of prescribing errors.The results of this study highlights the high medication error rates in pediatric ICU under the study, with administration and prescription errors marked the highest share of them. Hence implementing the effective strategies to reduce them are needed.
https://tips.sums.ac.ir/article_42190_13f7e169b7dd855b86022b9bc0d77f7b.pdf
2016-06-01
Medication Error
Intensive care unit
Pediatrics
Patient Safety
Critical illness
Saeedeh
Haghbin
1
Associate Professor of Pediatrics, Department of Pediatrics, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Sina
Shahsavari
2
Pharmacist, Shiraz University of Medical Sciences, Shiraz
AUTHOR
Afsaneh
Vazin
vazeena@sums.ac.ir
3
Associate Professor of Clinical pharmacy, Department of Clinical Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
Kohn L, Corrigan J, Donaldson M. To err is human: building a safer health system Washington: National Academy Press; 1999.
1
Miller MR, Robinson KA, Lubomski LH, Rinke ML, Pronovost PJ. Medication errors in paediatric care: a systematic review of epidemiology and an evaluation of evidence supporting reduction strategy recommendations. Qual Saf Health Care. 2007;16(2):116-26.
2
Williams DJP. Medication errors. J Roy Coll Phys Edinburgh. 2007;37(4):343.
3
Pharmacists ASoH-S. ASHP guidelines on preventing medication errors in hospitals. Am J Hosp Pharm. 1993;50:305-14.
4
Allan E, Barker K. Fundamentals of medication error research. Am J Hosp Pharm. 1990;47(3):555-71.
5
Hartwig S, Denger S, Schneider P. Severity-indexed, incident report-based medication error-reporting program. Am J Hosp Pharm. 1991;48(12):2611-6.
6
Wang H-f, Jin J-f, Feng X-q, Huang X, Zhu L-l, Zhao X-y, et al. Quality improvements in decreasing medication administration errors made by nursing staff in an academic medical center hospital: a trend analysis during the journey to Joint Commission International accreditation and in the post-accreditation era. Therapeut Clin Risk Manag. 2015;11:393-406.
7
Vazin A, Fereidooni M. Determining frequency of prescription, administration and transcription errors in internal intensive care unit of Shahid Faghihi Hospital in Shiraz with direct observation approach. Iran J Pharm Sci. 2012;8:189-94.
8
Vessal G. Detection of prescription errors by a unit-based clinical pharmacist in a nephrology ward. Pharm World Sci. 2010;32(1):59-65.
9
Khalili H, Farsaei S, Rezaee H, Dashti-Khavidaki S. Role of clinical pharmacistsâ interventions in detection and prevention of medication errors in a medical ward. Int J Clin Pharm. 2011;33(2):281-4.
10
Schneider MP, Cotting J, Pannatier A. Evaluation of nurses' errors associated in the preparation and administration of medication in a pediatric intensive care unit. Pharm World Sci. 1998;20(4):178-82.
11
Levine SR, Cohen M, Blanchard N, Federico F, Magelli M, Lomax C, et al. Guidelines for preventing medication errors in pediatrics. J Pediatr Pharmacol Ther. 2001;6:426-42.
12
Jennane N, Madani N, OuldErrkhis R, Abidi K, Khoudri I, Belayachi J, et al. Incidence of medication errors in a Moroccan medical intensive care unit. Int Arch Med. 2011;4:32.
13
Alsulami Z, Conroy S, Choonara I. Medication errors in the Middle East countries: a systematic review of the literature. Eur J Clin Pharmacol. 2013;69(4):995-1008.
14
Flynn EA, Barker KN, Pepper GA, Bates DW, Mikeal RL. Comparison of methods for detecting medication errors in 36 hospitals and skilled-nursing facilities. Am J Health Syst Pharm. 2002;59:436-46.
15
Dean BS, Allan EL, Barber ND, Barker KN. Comparison of medication errors in an American and a British hospital. Am J Health-Syst Pharm 1995;52:2543-9.
16
Wilmer A, Louie K, Dodek P, Wong H, Ayas N. Incidence of medication errors and adverse drug events in the ICU: a systematic review. Qual Saf Health Care. 2010;19:e7.
17
Tissot E, Cornette C, Demoly P, Jacquet M, Barale F, Capellier G. Medication errors at the administration stage in an intensive care unit. Intensive Care Med. 1999;25(4):353-9.
18
Vazin A, Delfani S. Medication errors in an internal intensive care unit of a large teaching hospital: a direct observation study. Acta Med Iran. 2012;50(6):425-32.
19
Alkhaja K, Alansari T, Damanhori A, Sequeira R. Evaluation of drug utilization and prescribing errors in infants: a primary care prescription-based study. Health Pol 2007;81(2-3):350â7.
20
Fahimi F, Ariapanah P, Faizi M, Shafaghi B, Namdar R, Ardakani MT. Errors in preparation and administration of intravenous medications in the intensive care unit of a teaching hospital: an observational study. Aust Crit Care. 2008;21(2):110-6.
21
Vazin A, Zamani Z, Hatam N. Frequency of medication errors in an emergency department of a large teaching hospital in southern Iran. Drug Healthc Patient Saf. 2014;6:179.
22
Pandolfini C, Bonati M, Rossi V, Santoro E, Choonara I, Naylor C, et al. The DEC-net European register of paediatric drug therapy trials: contents and context. Eur J Clin Pharmacol. 2008;64(6):611-7.
23
Bates DW. Using information technology to reduce rates of medication errors in hospitals. BMJ. 2000;320:788.
24
Ghaleb MA, Barber N, Franklin BD, Yeung VW, Khaki ZF, Wong IC. Systematic review of medication errors in pediatric patients. Ann Pharmacother. 2006;40:1766-76.
25
ORIGINAL_ARTICLE
In silico evaluation of rare codons and their positions in the structure of cytosine deaminase and substrate docking studies
Cytosine deaminase (CDase) is used with 5-fluorocytosine (5FC) for genetic cancer treatment. This approach has several undesirable features, such as a relatively poor turnover of 5FC and low prodrug conversion activities, thus limiting the overall therapeutic response. We previously reported the molecular cloning of a new type of CDase in E. coli AGH09. Here, we describe the hidden layer of information of rare codons in this gene, which can help in problem solving of protein expression. With the help of several web servers, some rare codons in different locations of CDase gene were identified. By in silico modelling of CDase in I-TASSER server, the three rare codons of Arg242, Arg286 and Arg360 were evaluated. All of these rare codons were located at special positions that seem to have a critical role in proper folding of CDase. In silico docking of the substrate binding site simulation with AutoDock Vina showed that Glu218 is involved in substrate binding site, but the others residues were incompatible. Structural analysis showed that rare codon of Arg286 is located adjacent to Glu218 in binding site, which may have a critical role in ensuring the correct formation of the binding site structure. Investigation of this hidden information can enhance our understanding of CDase folding. Moreover, studies of these rare codons help to clarify their role in rational design of new and effective drugs.
https://tips.sums.ac.ir/article_42191_f545b94a62319c431688f3b3e3bd61bc.pdf
2016-06-01
AutoDock
Bioinformatics analysis
CDase
Rare codon
Mojtaba
Mortazavi
1
Department of Biotechnology, Institute of Science and High Technology and Environmental Science, Graduate University of Advanced Technology, Kerman, Iran
AUTHOR
Navid
Nezafat
navidnezafat@yahoo.com
2
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran
AUTHOR
Manica
Negahdaripour
negahdaripour@sums.ac.ir
3
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran
and Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ahmad
Gholami
gholami@sums.ac.ir
4
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran
and Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Masoud
Torkzadeh-Mahani
5
Department of Biotechnology, Institute of Science and High Technology and Environmental Science, Graduate University of Advanced Technology, Kerman, Iran
AUTHOR
Safa
Lotfi
6
Department of Biotechnology, Institute of Science and High Technology and Environmental Science, Graduate University of Advanced Technology, Kerman, Iran
AUTHOR
Younes
Ghasemi
ghasemiy@sums.ac.ir
7
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
Negroni L, Samson M, Guigonis J-M, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90β phosphorylation. Molecular cancer therapeutics. 2007;6(10):2747-56.
1
Miyagi T, Koshida K, Hori O, Konaka H, Katoh H, Kitagawa Y, et al. Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system. The journal of gene medicine. 2003;5(1):30-7.
2
Kaliberov S, Chiz S, Kaliberova L, Krendelchtchikova V, Della Manna D, Zhou T, et al. Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity. Cancer gene therapy. 2006;13(2):203-14.
3
OH N. The conversion of 5-methyldeoxycytidine to thymidine in vitro and in vivo. 1957.
4
Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proceedings of the National Academy of Sciences. 1992;89(1):33-7.
5
Mahan SD, Ireton GC, Knoeber C, Stoddard BL, Black ME. Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Engineering Design and Selection. 2004;17(8):625-33.
6
Gholami A, Shahin S, Mohkam M, Nezafat N, Ghasemi Y. Cloning, Characterization and Bioinformatics Analysis of Novel Cytosine Deaminase from Escherichia coli AGH09. International Journal of Peptide Research and Therapeutics.1-10.
7
Ireton GC, Black ME, Stoddard BL. The 1.14 Ã
crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003;11(8):961-72.
8
Fuchita M, Ardiani A, Zhao L, Serve K, Stoddard BL, Black ME. Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-FluorocytosineâMediated Cell Killing In vitro and In vivo. Cancer research. 2009;69(11):4791-9.
9
Dix DB, Thompson RC. Codon choice and gene expression: synonymous codons differ in translational accuracy. Proceedings of the National Academy of Sciences. 1989;86(18):6888-92.
10
Kane JF. Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli. Current opinion in biotechnology. 1995;6(5):494-500.
11
Muhlrad D, Parker R. Premature translational termination triggers mRNA decapping. 1994.
12
Nakamura Y, Gojobori T, Ikemura T. Codon usage tabulated from international DNA sequence databases: status for the year 2000. Nucleic acids research. 2000;28(1):292-.
13
Chartier M, Gaudreault F, Najmanovich R. Large-scale analysis of conserved rare codon clusters suggests an involvement in co-translational molecular recognition events. Bioinformatics. 2012;28(11):1438-45.
14
Widmann M, Clairo M, Dippon J, Pleiss J. Analysis of the distribution of functionally relevant rare codons. BMC genomics. 2008;9(1):207.
15
Thanaraj T, Argos P. Protein secondary structural types are differentially coded on messenger RNA. Protein science. 1996;5(10):1973-83.
16
Goodluck U. ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization. BMC Bioinformatics. 2015;16:303.
17
Theodosiou A, Promponas VJ. LaTcOm: a web server for visualizing rare codon clusters in coding sequences. Bioinformatics. 2012;28(4):591-2.
18
Zhang Y. I-TASSER server for protein 3D structure prediction. BMC bioinformatics. 2008;9(1):40.
19
Kaplan W, Littlejohn TG. Swiss-PDB viewer (deep view). Briefings in Bioinformatics. 2001;2(2):195-7.
20
DeLano WL. The PyMOL molecular graphics system. 2002.
21
Clarke TF, Clark PL. Rare codons cluster. PLoS One. 2008;3(10):e3412.
22
Varenne S, Baty D, Verheij H, Shire D, Lazdunski C. The maximum rate of gene expression is dependent in the downstream context of unfavourable codons. Biochimie. 1989;71(11):1221-9.
23
Varenne S, Lazdunski C. Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism. Journal of theoretical biology. 1986;120(1):99-110.
24
Sonnhammer EL, Eddy SR, Durbin R. Pfam: a comprehensive database of protein domain families based on seed alignments. Proteins-Structure Function and Genetics. 1997;28(3):405-20.
25
Dong H, Nilsson L, Kurland CG. Co-variation of trna abundance and codon usage inescherichia coliat different growth rates. Journal of molecular biology. 1996;260(5):649-63.
26
Wu S, Zhang Y. LOMETS: a local meta-threading-server for protein structure prediction. Nucleic acids research. 2007;35(10):3375-82.
27
Guex N, Peitsch M. Swiss-PdbViewer: a fast and easy-to-use PDB viewer for Macintosh and PC. Protein Data Bank Quaterly Newsletter. 1996;77(7).
28
Vriend G. WHAT IF: a molecular modeling and drug design program. Journal of molecular graphics. 1990;8(1):52-6.
29
Tina K, Bhadra R, Srinivasan N. Nucleic Acids Res 35. Web Server issue) W473âW476. 2007.
30
Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of computational chemistry. 2010;31(2):455-61.
31
Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of computational chemistry. 2009;30(16):2785-91.
32
OLBoyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. Open Babel: An open chemical toolbox. J Cheminf. 2011;3:33.
33
Hall RS, Fedorov AA, Xu C, Fedorov EV, Almo SC, Raushel FM. Three-dimensional structure and catalytic mechanism of cytosine deaminase. Biochemistry. 2011;50(22):5077-85.
34
Wallace AC, Laskowski RA, Thornton JM. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein engineering. 1995;8(2):127-34.
35
Shahbazi M, Haghkhah M, Rahbar MR, Nezafat N, Ghasemi Y. In Silico Sub-unit Hexavalent Peptide Vaccine Against an Staphylococcus aureus Biofilm-Related Infection. International Journal of Peptide Research and Therapeutics. 2015:1-17.
36
Zamani M, Nezafat N, Negahdaripour M, Dabbagh F, Ghasemi Y. In silico evaluation of different signal peptides for the secretory production of human growth hormone in E. coli. International Journal of Peptide Research and Therapeutics. 2015:1-8.
37
Fattahi M, Malekpour A, Mortazavi M, Safarpour A, Naseri N. The Characteristics of Rare Codon Clusters in the Genome and Proteins of Hepatitis C Virus; a Bioinformatics Look. Middle East journal of digestive diseases. 2014;6(4):214.
38
Cheng T, Li Q, Zhou Z, Wang Y, Bryant SH. Structure-based virtual screening for drug discovery: a problem-centric review. The AAPS journal. 2012;14(1):133-41.
39
ORIGINAL_ARTICLE
Chemical assessment of eleven Cinnamon aromatic water populations from Fars (Iran) local markets in comparison to a standard sample
Current study aimed to chemically assess volatile constituents of eleven commercial cinnamon hydrosols purchased from Fars province (Iran) local markets in comparison to a standard sample. Via a liquid extractor, the volatile oil fractions of samples and also the standard hydrosol yielded from essential oil extraction of an authenticated cinnamon bark sample were recovered. Gas chromatography/ flame ionization detector (GC/FID) and subsequently GC/MS (GC/mass spectroscopy) were employed to assess and identify the chemical compositions of prepared samples. The procedure of analysis revealed in the appearance of totally 25 components. Cinnamaldehyde was found as the main constituent in ten populations (S2-S11) as well as in the standard sample (63.04-91.61%). Considerable amounts of Dibutyl phthalate, as a commonly used plasticizer was also detected in all samples. This is the first report of analysis and identification of volatile constituent in cinnamon hydrosol, a common medicinal beverage. Although, high amount of Cinnamaldehyde in cinnamon hydrosol can introduce this tasty medicinal beverage for further studies similar to the respective botanical part or various usual extracts, more comprehensive monitoring is to be performed on safety, purity and quality of such preparation.
https://tips.sums.ac.ir/article_42192_4cefcab15c909e776ff398793733bf0b.pdf
2016-06-01
Aromatic water
Cinnamomum verum J.Presl
GC/MS
Hydrosol
Volatile constituent
Bita
Shahpar
1
Shiraz University of Medical Sciences, International Branch
LEAD_AUTHOR
Mahmoodreza
Moein
2
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. and Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohammad M.
Zarshenas
zarm@sums.ac.ir
3
Department of Phytopharmaceuticals
(Traditional Pharmacy), School of Pharmacy
and Pharmaceutical Sciences Research Center,
Shiraz University of Medical Sciences,
Shiraz, Iran
AUTHOR
Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, et al. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Canadian journal of physiology and pharmacology. 2007 Sep;85(9):837-47. PubMed PMID: 18066129. Epub 2007/12/11. eng.
1
Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biological research. 2009;42(1):93-8.
2
Rattanachaikunsopon P, Phumkhachorn P. Potential of cinnamon (Cinnamomum verum) oil to control Streptococcus iniae infection in tilapia (Oreochromis niloticus). Fish Sci. 2010 2010/03/01;76(2):287-93. English.
3
Duraipandiyan V, Ignacimuthu S. Antifungal activity of traditional medicinal plants from Tamil Nadu, India. Asian Pacific Journal of Tropical Biomedicine. 2011 10//;1(2, Supplement):S204-S15.
4
Mathew S, Abraham TE. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chemistry. 2006;94(4):520-8.
5
Park I-K, Park J-Y, Kim K-H, Choi K-S, Choi I-H, Kim C-S, et al. Nematicidal activity of plant essential oils and components from garlic (Allium sativum) and cinnamon (Cinnamomum verum) oils against the pine wood nematode (Bursaphelenchus xylophilus). Nematology. 2005;7(5):767-74.
6
Pandey M, Chandra DR. Evaluation of Ethanol and Aqueous extracts of Cinnamomum verum Leaf Galls for Potential Antioxidant and Analgesic activity. Indian J Pharm Sci. 2015 Mar-Apr;77(2):243-7. PubMed PMID: 26009661. Pubmed Central PMCID: PMC4442477. Epub 2015/05/27. eng.
7
Medagama AB. The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutr J. 2015;14(1):108. PubMed PMID: 26475130. Pubmed Central PMCID: PMC4609100. Epub 2015/10/18. eng.
8
Kadan S, Saad B, Sasson Y, Zaid H. In Vitro Evaluations of Cytotoxicity of Eight Antidiabetic Medicinal Plants and Their Effect on GLUT4 Translocation. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:549345. PubMed PMID: 23606883. Pubmed Central PMCID: PMC3625546. Epub 2013/04/23. eng.
9
Okutan L, Kongstad KT, Jager AK, Staerk D. High-resolution alpha-amylase assay combined with high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy for expedited identification of alpha-amylase inhibitors: proof of concept and alpha-amylase inhibitor in cinnamon. J Agric Food Chem. 2014 Nov 26;62(47):11465-71. PubMed PMID: 25368916. Epub 2014/11/05. eng.
10
Abeysekara W, Premakumara G, Ratnasooriya W. Anti-cholinesterase activity of bark and leaf extracts of Ceylon cinnamon (Cinnamomum zeylanicum Blume) in vitro. 2015.
11
Khasnavis S, Pahan K. Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 Jun;7(2):424-35. PubMed PMID: 21701815. Pubmed Central PMCID: PMC3189510. Epub 2011/06/28. eng.
12
Assadollahi V, Gholami M, Zendedel A. C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1). Bratislavske lekarske listy. 2015;116(2):132-5. PubMed PMID: 25665482. Epub 2015/02/11. eng.
13
Chaudhary SS, Tariq M, Zaman R, Imtiyaz S. The In vitro anti-acne activity of two unani drugs. Ancient science of life. 2013 Jul;33(1):35-8. PubMed PMID: 25161328. Pubmed Central PMCID: PMC4140019. Epub 2014/08/28. eng.
14
Harada M, Hirayama Y, Yamazaki R. Pharmacological studies on Chinese cinnamon. V. Catecholamine releasing effect of cinnamaldehyde in dogs. Journal of pharmacobio-dynamics. 1982 Aug;5(8):539-46. PubMed PMID: 6130136. Epub 1982/08/01. eng.
15
Khan A, Safdar M, Khan MMA, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes care. 2003;26(12):3215-8.
16
Rao PV, Gan SH. Cinnamon: A Multifaceted Medicinal Plant. Evidence-based complementary and alternative medicine : eCAM. 2014 04/10
17
/01/received
18
/12/accepted;2014:642942. PubMed PMID: PMC4003790.
19
Singh G, Maurya S, DeLampasona MP, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Sep;45(9):1650-61. PubMed PMID: 17408833. Epub 2007/04/06. eng.
20
Zarshenas MM., Sakhteman A., Etemadfard H., Moein MR. Trachyspermum ammi Hydrosol, An Almost Pure Source of Thymol; Analysis of the Recovered Essential Oil from Different Samples. International Journal of Pharmacognosy and Phytochemical Research. 2015;7(3):457-60.
21
Catty S. Hydrosols: the next aromatherapy: Inner Traditions/Bear & Co; 2001.
22
Moein M, Zarshenas MM, Delnavaz S. Chemical composition analysis of rose water samples from Iran. Pharmaceutical biology. 2014 Oct;52(10):1358-61. PubMed PMID: 24863280. Epub 2014/05/28. eng.
23
Thomas F. PDR for Herbal Medicine. Montval New Jersy: Medical Economics Company. 2000:829-30.
24
Matsumoto M, Hirata-Koizumi M, Ema M. Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction. Regulatory Toxicology and Pharmacology. 2008 2//;50(1):37-49.
25
Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Critical reviews in food science and nutrition. 2011 Jul;51(6):547-62. PubMed PMID: 21929331. Epub 2011/09/21. eng.
26
Inuzuka K. Ï Electronic Structure of Cinnamaldehyde. Bulletin of the Chemical Society of Japan. 1961;34(11):1557-60.
27
Sun Q, Shang B, Wang L, Lu Z, Liu Y. Cinnamaldehyde inhibits fungal growth and aflatoxin B1 biosynthesis by modulating the oxidative stress response of Aspergillus flavus. Applied Microbiology and Biotechnology. 2015:1-10.
28
Ling F, Jiang C, Liu G, Li M, Wang G. Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius. Parasitology. 2015.
29
Zhao J, Zhang X, Dong L, Wen Y, Zheng X, Zhang C, et al. Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia. British Journal of Pharmacology. 2015;172(20):5009-23.
30
Yang D, Liang XC, Shi Y, Sun Q, Liu D, Liu W, et al. Anti-oxidative and anti-inflammatory effects of cinnamaldehyde on protecting high glucose-induced damage in cultured dorsal root ganglion neurons of rats. Chinese journal of integrative medicine. 2016 Jan;22(1):19-27. PubMed PMID: 26577110. Epub 2015/11/19. eng.
31
Gowder SJ, Devaraj H. Effect of the food flavour cinnamaldehyde on the antioxidant status of rat kidney. Basic & clinical pharmacology & toxicology. 2006;99(5):379-82.
32
Li J-E, Futawaka K, Yamamoto H, Kasahara M, Tagami T, Liu T-H, et al. Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. The American journal of Chinese medicine. 2015;43(05):879-92.
33
Wang F, Pu C, Zhou P, Wang P, Liang D, Wang Q, et al. Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2. Cellular Physiology and Biochemistry. 2015;36(1):315-24.
34
ElâRaouf A, Ola M, ElâSayed ESM, Manie MF. Cinnamic Acid and Cinnamaldehyde Ameliorate CisplatinâInduced Splenotoxicity in Rats. Journal of biochemical and molecular toxicology. 2015;29(9):426-31.
35
Kuçukgul Gulec A, Altinterim B, Aksu O. Determination of lethal concentration (LC50) values of Cinnamomum zeylanicum hydrosol on carp fish. Iranian Journal of Fisheries Sciences. 2013;12(1):34-44.
36
Roussis V, Tsoukatou M, Petrakis PV, Ioanna C, Skoula M, Harborne JB. Volatile constituents of four Helichrysum species growing in Greece. Biochemical Systematics and Ecology. 2000 3//;28(2):163-75.
37
Sabulal B, Dan M, J AJ, Kurup R, Chandrika SP, George V. Phenylbutanoid-rich rhizome oil of Zingiber neesanum from Western Ghats, southern India. Flavour and Fragrance Journal. 2007;22(6):521-4.
38
Methven L, Tsoukka M, Oruna-Concha MJ, Parker JK, Mottram DS. Influence of sulfur amino acids on the volatile and nonvolatile components of cooked salmon (Salmo salar). J Agric Food Chem. 2007 Feb 21;55(4):1427-36. PubMed PMID: 17253713. Epub 2007/01/27. eng.
39
Bouzouita N, Kachouri F, Hamdi M, Chaabouni MM. Antimicrobial activity of essential oils from Tunisian aromatic plants. Flavour and Fragrance Journal. 2003;18(5):380-3.
40
da Silva JD, Luz AIR, da Silva MHL, Andrade EHA, Zoghbi MdGB, Maia JGS. Essential oils of the leaves and stems of four Psidium spp. Flavour and Fragrance Journal. 2003;18(3):240-3.
41
Radulescu V, Chiliment S, Oprea E. Capillary gas chromatography-mass spectrometry of volatile and semi-volatile compounds of Salvia officinalis. Journal of chromatography A. 2004 Feb 20;1027(1-2):121-6. PubMed PMID: 14971492. Epub 2004/02/20. eng.
42
Yañez X, Pinzon ML, Solano F, Sanchez LR. Chemical composition of the essential oil of Psidium caudatum McVaugh. Molecules. 2002;7(9):712-6.
43
Tzakou O, Harvala C, Galati E, Sanogo R. Essential oil composition of Nepeta argolica Bory et Chaub. subsp. argolica. Flavour and Fragrance Journal. 2000;15(2):115-8.
44
Shalit M, Katzir N, Tadmor Y, Larkov O, Burger Y, Shalekhet F, et al. Acetyl-CoA: alcohol acetyltransferase activity and aroma formation in ripening melon fruits. Journal of Agricultural and Food Chemistry. 2001;49(2):794-9.
45
Tepe B, Sokmen M, Sokmen A, Daferera D, Polissiou M. Antimicrobial and antioxidative activity of the essential oil and various extracts of Cyclotrichium origanifolium (Labill.) Manden. & Scheng. Journal of Food Engineering. 2005;69(3):335-42.
46
Bylaite E, Meyer AS. Characterisation of volatile aroma compounds of orange juices by three dynamic and static headspace gas chromatography techniques. European food research and technology. 2006;222(1-2):176-84.
47
Barbosa LC, Paula VF, Azevedo AS, Silva EA, Nascimento EA. Essential oil composition from some plant parts of Conyza bonariensis (L.) Cronquist. Flavour and fragrance journal. 2005;20(1):39-41.
48
Mahattanatawee K, Goodner KL, Baldwin EA, editors. Volatile constituents and character impact compounds of selected Floridaâs tropical fruit. Proc Fla State Hort Soc; 2005.
49
Lucero ME, Fredrickson EL, Estell RE, Morrison AA, Richman DB. Volatile composition of Gutierrezia sarothrae (broom snakeweed) as determined by steam distillation and solid phase microextraction. Journal of Essential Oil Research. 2006;18(2):121-5.
50
Alonzo G, Fatta Del Bosco S, Palazzolo E, Saiano F, Tusa N. Citrus somatic hybrid leaf essential oil. Flavour and fragrance journal. 2000;15(4):258-62.
51
Liolios C, Laouer H, Boulaacheb N, Gortzi O, Chinou I. Chemical composition and antimicrobial activity of the essential oil of Algerian Phlomis bovei De Noe subsp. bovei. Molecules. 2007;12(4):772-81.
52
Chieng T, Assim Z, Fasihuddin B. Toxicity and antitermite activities of the essential oils from Piper sarmentosum. The Malaysian Journal of Analytical Sciences. 2008;12(1):234-9.
53
Alissandrakis E, Kibaris AC, Tarantilis PA, Harizanis PC, Polissiou M. Flavour compounds of Greek cotton honey. Journal of the science of food and agriculture. 2005;85(9):1444-52.
54
Vagionas K, Ngassapa O, Runyoro D, Graikou K, Gortzi O, Chinou I. Chemical analysis of edible aromatic plants growing in Tanzania. Food chemistry. 2007;105(4):1711-7.
55
Maggi F, Bilek T, Lucarini D, Papa F, Sagratini G, Vittori S. Melittis melissophyllum L. subsp. melissophyllum (Lamiaceae) from central Italy: A new source of a mushroom-like flavour. Food Chemistry. 2009;113(1):216-21.
56
SimiÄ A, SokoviÄ MD, RistiÄ M, GrujiÄâJovanoviÄ S, VukojeviÄ J, Marin PD. The chemical composition of some Lauraceae essential oils and their antifungal activities. Phytotherapy Research. 2004;18(9):713-7.
57
Fan G, Lu W, Yao X, Zhang Y, Wang K, Pan S. Effect of fermentation on free and bound volatile compounds of orange juice. Flavour and fragrance journal. 2009;24(5):219-25.
58
Javidnia K, Miri R, Kamalinejad M, Edraki N. Chemical composition of Ferula persica Wild. essential oil from Iran. Flavour and fragrance journal. 2005;20(6):605-6.
59
Zeng Y-X, Zhao C-X, Liang Y-Z, Yang H, Fang H-Z, Yi L-Z, et al. Comparative analysis of volatile components from Clematis species growing in China. Analytica chimica acta. 2007;595(1):328-39.
60
Fokialakis N, Prokopios M, Mitaku S. Essential oil constituents of Valeriana italica and Valeriana tuberosa. Stereochemical and conformational study of 15-acetoxyvaleranone. Zeitschrift für Naturforschung C. 2002;57(9-10):791-6.
61
ORIGINAL_ARTICLE
Predicting the functionality of major intrinsic proteins: An in silico analysis in Musa
Major intrinsic proteins (MIPs) are tetrameric complexs with six transmembrane domains. MIPs which are involved in water and nutrient permeability have been called aquaporins and aquaglyceroporins respectivly. Four important subfamilies of MIPs are plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), nodolin-26 like intrinsic proteins (NIPs) and small basic intrinsic proteins (SIPs). Musa sp. from the order Zingiberals is not only the largest supply of food for millions of people but also has tremendous therapeutic properties like ameliorating digestive and metabolic disorders. This species is sensitive to any kind of water deficit. Recently the genomic sequence of Musa acuminata has been determined. Besides the localization of MaMIP genes on the chromosomes and the localization of MaMIP proteins in subcellular compartments, the substrate selectivity of MaMIPs has been determined by dual NPA (Asparagine-Prolin-Alanine) motifs, the ar/R (aromatic/Arginine) selectivity filter and Froger’s position. MaPIP subfamilies were transporters of water, boron, carbon dioxide, hydrogen peroxide and urea. MaTIP subfamilies were transporters of water, hydrogen peroxide, urea and ammonia. MaNIP subfamily has been shown to be transporters of silicon, urea and boron. This functional prediction of the MaMIP roles provides the opportunity to genetically target these passive transporters for the improvement of the species trait.
https://tips.sums.ac.ir/article_42193_0e4b03a7646638ffadf876e110e5c87f.pdf
2016-06-01
Musa acuminata
major intrinsic protein
aquaporin
protein function
substrate selectivity
Shiva
Hemmati
hemmatish@sums.ac.ir
1
LEAD_AUTHOR
ORIGINAL_ARTICLE
Preparation of Enteric Coated Pellets Containing Lansoprazole Using Extrusion/Spheronization Technique
Lansoprazole degrades rapidly in an aqueous solution at low pH values. Degradation rate increases at pH values below 4 .The aim of this study was development of enteric coated pellets containing Lansoprazole by an extrusion/ spheronization technique. Eight different formulations based on lactose and six different formulations based on mannitol, consisting of different portions of other excipients including sucrose, hydroxy propyl methyl cellulose, magnesium carbonate, and sodium lauryl sulfate have been prepared. Feret diameter, shape factor, and amount of drug released were determined for each formulation. Among different formulations, F14, which consists of mannitol, sucrose, HPMC, talc, magnesium carbonate, and lansoprazole, is considered to be the best formulation. Six other different formulations for the preparation of enteric coatings based on Eudragit S100, Eudragit L100, triethyl citrate, and talc were prepared and coating procedure on pellets (F14) was performed using coating pan. In vitro drug release tests in acidic media (pH=1.2) and buffer media (pH=6.8) were performed for pellets, coated with each coating formulation and dissolution profile for each formulation was prepared. The pellets coated by formulation F.C 4, consisting of Eudragit L 100, triethylcitrate, and talc, showed a proper in vitro drug release profile. Accelerated stability tests were performed on coated pellets according to USP, and data suggested that pellets will be stable for 2 years
https://tips.sums.ac.ir/article_42194_686c3e35903e2046f68e130762ec336f.pdf
2016-06-01
Tavakol
Heidari Shayesteh
1
Department of Medicinal Chemistry, School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran.
AUTHOR
Mina
Abbasnia
2
Department of Pharmaceutics, School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran.
AUTHOR
Reza
Mahjub
rmahjub@gmail.com
3
Department of Pharmaceutics, School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran.
LEAD_AUTHOR
Koo OM, Heng PW. The Influence of Microcrystalline Cellulose Grade on Shape and Shape Distributions of Pellets Produced by Extrusion-Spheronization. Chem Pharm Bull (Tokyo). 2001;49:1383-7.
1
Abbaspour MR, Sadeghi F, Afrasiabi Gharekani H. Design and study of ibuprofen disintegrating sustained-release tablets comprising coated pellets. Eur J Pharm Biopharm. 2008;68:747-59.
2
Podczeck F, Knight P. The Evaluation of Formulations for the Preparation of Pellets with High Drug Loading by Extrusion/Spheronization. Pharm Dev Technol. 2006;11:263-74.
3
Tomer G, Podczeck F, Newton JM. The influence of model drugs on the preparation of pellets by extrusion/spheronization: II. Spheronization parameters. Int J Pharm. 2002;231:107-19.
4
Gherbre Sellasie Issac. (2005).Pharmaceutical pelletization technology. New York, US: Marcel Dekker.
5
Fielden KE, Newton JM, Rowe RC. Movement of liquids throw powder beds. Int J Pharm.1992;79:47-60.
6
Piao J, Lee JE, Weon KY, Kim DW, Lee JS, Park JD, Nishiyama Y, Fukui I, Kim JS. Development of Novel Mucoadhesive Pellets of Metformin Hydrochloride. Arch Pharm Res. 2009;32:391-97.
7
Dietrich R, Brausse R. Validation of the pellet coating process used for a new sustained-release theophylline formulation. Arzneimittelforschung. 1988;38:1210-9.
8
Kramar A, Turk S, Verecer F. Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films. Int J Pharm. 2003;256:43-52.
9
Kablitz CD, Harder K, Urbanetz NA. Dry coating in a rotary fluid bed. Eur J Pharm Sci. 2006;27:212-19.
10
el-Mahdi IM, Deasy PB. Tableting of coated ketoprofen pellets. J Microencapsul. 2000;17:133-44.
11
Ganesan M, Pal TK, Jayakumar M. Pellet coating by air suspension technique using a mini-model coating unit. Boll Chim Farm. 2003;142:290-4.
12
Sachs G, Shin JM, Howden CW. Review article: The clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 2006;23:2-8.
13
Michael R. Riley. 2000). Drug facts and comparisons. Missouri, US: facts and comparisons®
14
Tabata T, Makino T, Kikuta J, et al. Manufacturing method of stable enteric granules of a new antiulcer drug (Lansoprazole). Drug Dev Ind Pharm. 1994;20:1661-72.
15
Tutunji MF, Qaisi AM, El-Eswed B, Tutunji LF. An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile. Int J pharm. 2006;323:110-16.
16
Deasy PB, Law FML. Use of extrusion-spheronization to develop an improved oral dosage form of indomethacin. Int J Pharm. 1997; 148:201-9.
17
Sheng JJ, Kasim NA, Chandrasekharan R, Amidon GL. Solubilization and dissolution of insoluble weak acid, ketoprofen: effects of pH combined with surfactant. Eur J Pharm Sci. 2006;29: 306-14.
18
Shah VP, Konecny JJ, Everett RL, McCullough B, Noorizadeh AC, Skelly JP. In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. Pharm Res. 1989; 6:612-8.
19
Balaxi M, Nikolakakis I, Kachrimanis K, Malamataris S. Combined effects of wetting, drying, and microcrystalline cellulose type on the mechanical strength and disintegration of pellets. J Pharm Sci. 2009;98:676-89.
20
Balogh E, Kallai N, Dredan J, Lengyel M, Klebovich I, Antal I. Application of computer image analysis for characterization of pellets. Acta Pharm Hung. 2007;77:123-31.
21
Jin Y, Wang YF, Wang CR, et al. Preparation of sustained-release and enteric coated pellets of pantoprazole. Chinese Pharmaceutical Journal. 2009;44:997-1001
22
Zhang SQ, Rahman Z, Thumma S, Repka MA, Chen GH, Li SM. Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome. Drug Dev Ind Pharm. 2009;35:57-64
23
Sinchaipanid N, Chitropas P, Mitrevej A. Influences of Layering on Theophylline Pellet Characteristics. Pharm Dev Technol. 2004;9:163-70.
24
Kleinebudde P, Schröder M, Schultz P, Müller BW, Waaler T, Nymo L. Importance of the Fraction of Microcrystalline Cellulose and Spheronization Speed on the Properties of Extruded Pellets Made from Binary Mixtures. Pharm Dev Technol. 1999;4:397-404.
25
Chatchawalsaisin J, Podczeck F, Newton JM. The preparation by extrusion/spheronization and the properties of pellets containing drugs, microcrystalline cellulose and glyceryl monostearate. Eur J Pharm. 2005;24:35-48.
26
Asghar LF, Chure CB, Chandran S. Colon specific delivery of indomethacin: Effect of incorporating pH sensitive polymers in xanthan gum matrix bases. AAPS PharmSciTech. 2009;10:335-45.
27
ORIGINAL_ARTICLE
QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents
Dichloroacetate (DCA) is a pyruvate mimetic compound that stimulates the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA works by turning on the apoptosis which is suppressed in tumor cells, hence let them to die on their own. Here, in this paper a series of DCA analogues were applied to quantitative structure–activity relationship (QSAR) analysis. A collection of chemometrics methods such as multiple linear regression (MLR), factor analysis–based multiple linear regression (FA-MLR), principal component regression (PCR), simple Free-Wilson analysis (FWA) and partial least squared combined with genetic algorithm for variable selection (GA-PLS) were conducted to make relations between structural features and cytotoxic activities of a variety of DCA derivatives. The best multiple linear regression equation obtained from genetic algorithms partial least squares which predict 91% of variances. On the basis of the produced model, an in silico-screening study was also employed and new potent lead compounds based on new structural patterns were suggested. Docking studies of these compounds were also investigated and promising results were obtained. The docking results were also conducted to protein ligand interaction fingerprints (PLIF) studies using self-organizing map (SOM) in order to evaluate the predictive ability in suggesting new potent compounds and some compounds were introduced as a good candidates for synthesis.
https://tips.sums.ac.ir/article_42195_072396b245b96fd805158616da82a912.pdf
2016-06-01
in silico screening
molecular docking
N-phenyl dichloroacetamide
protein ligand interaction fingerprints
QSAR
Masood
Fereidoonnezhad
masood6289@gmail.com
1
AUTHOR
Zeinab
Faghih
faghihz@sums.ac.ir
2
AUTHOR
Elham
Jokar
e.jokar@gamil.com
3
AUTHOR
Ayyub
Mojaddami
mojaddamia@sums.ac.ir
4
AUTHOR
Zahra
Rezaei
rezaeiz@sums.ac.ir
5
AUTHOR
Mehdi
Khoshneviszadeh
khoshnevim@sums.ac.ir
6
LEAD_AUTHOR