Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
Recent creative innovations for modernizing traditional medicine
1
4
EN
Ghazaleh
Mosleh
0000-0001-5664-4823
Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran
moslehgh@sums.ac.ir
Abdolali
Mohagheghzadeh
0000-0002-4873-1449
Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
mohaghegh@sums.ac.ir
10.30476/tips.2021.93166.1119
< p>Traditional medicine with a profound historical background is a rich source of clinical experiences for thousands of years. It has shown promising therapeutic effects on complex disorders with a holistic approach. However, the multi-component and multi-target pharmacology of traditional drugs are not clearly understood with the current reductionist approach. Modernization of traditional medicine (TM) by means of modern technology and academic thoughts as well as innovative methods and scientific experiments helps better perception of the ancient wisdom behind traditional mechanisms. Besides, modernization of TM via new ideas from the globally accepted scientific standards can result in a series of highly active, safe, and controllable modern TM products. In this approach, advanced technology and innovative methodology play a key role in TM development. On the other hand, personalized medicine paradigm which is recommended in TM theories aims to achieve the proper diagnosis and treatment for each patient. It particularly focuses on the maintenance of health and enhancing the resistance of body to diseases. The present work was conducted to emphasis the pivotal role of utilizing modern innovations in TM systems
Innovation,Traditional medicine,Systems biology
https://tips.sums.ac.ir/article_48014.html
https://tips.sums.ac.ir/article_48014_42eb4d1a7a6099a36c71416b449d916a.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
Appropriateness of Sildenafil Prescribing in Pulmonary Hypertension with Valvular Heart Disease: A Single Centre Study
5
12
EN
Tze Hoon
Goo
0000-0002-2933-1079
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
gtzehoon@gmail.com
Farizan
Abdul Ghaffar
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
farizan.ag@gmail.com
Wardati
Mazlan Kepli
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
warda2308@gmail.com
Nur Atiqah
Zulkifli
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
atiqahz93@gmail.com
Yen Chie
Lim
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
yenchie1040@gmail.com
Chen Wei
Cheng
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
derrick_c_wei@hotmail.com
10.30476/tips.2021.92905.1115
Oral sildenafil has proven efficacy in pulmonary hypertension in current clinical practice. However, there is a research gap in sildenafil prescribing among patients with valvular heart disease (VHD) and pulmonary hypertension (PH) in Malaysia. This study aimed to determine the appropriateness of sildenafil prescribing and rehospitalization rate in patients with corrected VHD and PH. This is a retrospective descriptive study using universal sampling with a calculated sampling size of 123. Patients who were diagnosed with VHD and PH in Hospital Serdang were recruited from 2014 - 2018. Patients' demographic and clinical characteristics were retrieved from Electronic Hospital Information System (eHIS) and recorded using a pre-designed data collection form. Appropriateness prescribing of sildenafil included appropriate dose(20mg to 80mg three times daily) and duration(total of eight weeks of sildenafil treatment that started before and continued after surgery). Rehospitalization is defined as any hospitalization within six months after surgery. Data were analyzed using descriptive and inferential statistics. From 123 patients (44.7% male, 55.3% female), 41% (n=51) and 61.8%(n=76) received appropriate dose and duration of Sildenafil respectively. Rehospitalization rate within six months after valve surgery was 55.3%(n=68). Univariate analysis showed that patients more than 65 years old (p=0.039), atrial fibrillation (AF) (p=0.04) and female (p=0.002) received appropriate prescribing of sildenafil. Only female patients and patients with AF were the predictors of appropriate prescribing of sildenafil. The role of sildenafil in VHD and PH remains unclear and needs further research in different perspectives such as short term and long-term duration with different doses.
Appropriateness,pulmonary hypertension,sildenafil,valvular heart disease
https://tips.sums.ac.ir/article_48017.html
https://tips.sums.ac.ir/article_48017_2f356ccee560d5c3d4b2b6f748f473af.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
The therapeutic potential of trifluoperazine against ethanol and cold water stress-induced gastric lesions in rat
13
24
EN
Mohammad
Javad
Khoshnoud
0000-0003-2907-2596
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
khoshnoudm@sums.ac.ir
Marzieh
Rashedinia
0000-0001-8395-2944
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
rashedinia@sums.ac.ir
Majid
Keshavarzi
0000-0002-0173-2233
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
keshavarzi_majid@yahoo.com
Amir Hosein
Sakhteman
0000000219226523
Department of Medicinal Chemistry, Shiraz University of Medical Sciences, Shiraz, Iran.
asakhteman@sums.ac.ir
Vida
Izadi
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
vidaizadipharmacy88@gmail.com
Amin
Derakhshanfar
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
derakhshanfar@sums.ac.ir
10.30476/tips.2021.92622.1112
Gastric erosion is a multifactorial etiological disorder. The study aimed to evaluate the therapeutic effect of trifluoperazine (TFP ) on gastric lesioninduced by cold-water stress and ethanol in rats. TFP 5, 10 and 20 mg/kg as well as pantoprazole (20 mg/kg), as the standard treatment, was administered via oral gavage, 1 h before gastric lesion-induced by 50% ethanol (5 ml/kg per oral) or immersion in cold water (20-22 °C) in rats. Animals were anesthetized 1 h after ethanol gavage or 4 h after immersion in cold water. The stomach tissue was removed and allocated for histopathological and biochemical parameters including malondialdehyde (MDA )level, superoxide dismutase (SOD) and catalase (CAT) activity assay. Both models were induced significant increase in MDA level and decrease in SOD and CAT activity. Pre-treatment with TFP at doses of 10 and 20 mg/kg significantly increased the activity of SOD and CAT enzymes and decreased the concentration of MDA in both models. Also, pre-treatment with TFP ameliorated ethanol and cold-water stress-induced damage. TFP demonstrated gastric mucosal protection against oxidative injuries caused by ethanol and cold-water stress because of its antioxidant properties and inhibition of toxic oxidant in the stomach tissues.
Please cite this article as: Mohammad Javad Khoshnoud, Marzieh Rashedinia, Majid Keshavarzi, Amir Hosein Sakhteman, Vida Izadi, Amin Derakhshanfar. The therapeutic potential of trifluoperazine against ethanol and cold water stress-induced gastric lesions in rat. Trends in Pharmaceutical Sciences. 2022;8(1):13-24 .doi: 10.30476/TIPS.2021.92622.1112
Cold-water stress,Ethanol,Oxidative stress,Stomach Ulcer,Trifluoperazine
https://tips.sums.ac.ir/article_47904.html
https://tips.sums.ac.ir/article_47904_bfe757138a12818ebd92a655aaa62dc4.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer
25
36
EN
Devadath
NG
0000-0002-1505-666X
Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences,
Bengaluru-560054, India.
devadathng@gmail.com
Ashoka Babu
VL
Department of Pharmacognosy, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences,
Bengaluru-560054, India.
ababu007us@gmail.com
Basavaraj
BV
Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences,
Bengaluru-560054, India.
bvbasu@gmail.com
Mohammad
Azamthulla
0000-0001-8292-0406
Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences,
Bengaluru-560054, India.
mohammadazamthulla@gmail.com
10.30476/tips.2021.93365.1124
Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of R. densiflora (Roth) DC leaves was prepared by Soxhlet extraction and subjected to phytochemical analysis. Microballoons loaded with ethanolic extract of R. densiflora leaf were developed by solvent evaporation method and characterized by optical microscopy, floating time, and release characteristics. Acute oral toxicity study of microballons was carried out following OECD guidelines 423 and antiulcer activity was performed by pylorus ligation, indomethacin and cystamine induced duodenal ulcer methods. R. densiflora extract was found to contain glycosides, proteins, flavonoids, phenolic compounds, tannins and saponins. The particle size of microballoons of R. densiflora extract was found to be in the range of 300 μm. Acute toxicity studies of microballoons did not produce any toxic symptoms and mortality in animals, hence 100 and 200 mg/kg concentrations were selected to screen antiulcer activity. Both the doses showed significant gastric ulcer healing effect and gastric antisecretory effect in pylorus ligated rats, gastric cytoprotective effect in indomethacin induced gastric ulcer and also produced a significant reduction in duodenal ulcers. Dose of 200 mg/kg showed highly significant antiulcer activity than 100 mg/kg. Thus, it is concluded that floating microballoons loaded with R. densiflora extract significantly reduced gastric acid secretion, increased healing of gastric ulcers and also prevent the duodenal ulcers in rats.
Please cite this article as: Devadath NG, Ashoka Babu VL, Basavaraj BV, Mohammad Azamthulla. Floating Microballoons for the treatment of Peptic Ulcer. Trends in Pharmaceutical Sciences. 2022;8(1):25-36.
doi: 10.30476/TIPS.2021.93365.1124
peptic ulcer,Microspheres,Rhynchosia densiflora (Roth) DC,Pylorus Ligation,Gastric acid,Antiulcer agents
https://tips.sums.ac.ir/article_48015.html
https://tips.sums.ac.ir/article_48015_560be8f7e31588705512138cb9e2f32a.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
Preparation and in vitro evaluation of controlled release granules of mesalazine for colon targeted drug delivery system
37
42
EN
Sanaz
Mehdi-alamdarlou
0000-0001-6446-0098
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
mehdialamdarlou@sums.ac.ir
Negin
Mozafari
0000-0001-8711-2651
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
neginmozafari@sums.ac.ir
Saeid
Daneshamooz
0000-0003-0849-6736
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
daneshamuz@sums.ac.ir
Hajar
Ashrafi
0000-0002-0205-7217
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
hashrafi@sums.ac.ir
10.30476/tips.2021.92954.1116
Targeted drug delivery systems into the colon to cure different local diseases like ulcerative colitis, cancer, and irritable bowel diseases have gained attention. These drug delivery systems are more effective for local inflammation and have limited side effects. The purpose of the present study is to formulate a controlled-release system of mesalazine, an anti-inflammatory agent by fluidized bed coating. The formulation was prepared using hydroxyl propyl methylcellulose as sustained delivery and cellulose acetate phthalate for enteric-coated behavior. The prepared granules were evaluated for particles size, moisture content, friability, dissolution test. The granules made with wet granulation had a suitable size and free flowability with carr's index lower than 20. It was concluded that the prepared granules could be successfully formulated with the use of release retarding polymers. The formulation showed appropriate release retardation of the drug, indicating the potential of a delivery system. A further investigation like capsule preparation and microbial count examination is needed for better evaluation of the formulation.
Please cite this article as: Sanaz Mehdi-alamdarlou, Negin Mozafari, Saeid Daneshamouz, Hajar Ashrafi. Preparation and in vitro evaluation of controlled release granules of mesalazine for colon targeted drug delivery system. Trends in Pharmaceutical Sciences. 2022;8(1):37-42 .doi: 10.30476/TIPS.2021.92954.1116
cellulose acetate phthalate,controlled release,Inflammation,hydroxyl propyl methylcellulose,Mesalazine
https://tips.sums.ac.ir/article_48016.html
https://tips.sums.ac.ir/article_48016_9873a8a6c8b6e59027bd75833518e3fe.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
A Tablet Matrix with Hibiscus rosa Sinensis Leave Mucilage for Effective Treatment of Rare Lymphangioleiomyomatosis Using Sirolimus
43
50
EN
Hindustan
Abdul Ahad
0000-0001-5329-6878
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
abdulhindustan@gmail.com
Haranath
Chinthaginjala
0000-0001-8604-6306
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
haranathriper@gmail.com
Yarragunta
Roja
0000-0002-4071-2833
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
yarraguntaroja@gmail.com
Kandlapalli
Swathi
0000-0003-3952-6280
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
kandlapalliswathi100@gmail.com
Pandre
Shravya
0000-0001-5425-9921
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
pandreshravya2002@gmail.com
Anam
Rashi
0000-0001-5641-8308
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu-515721 Andhra Pradesh, India.
anamreshi99@gmail.com
10.30476/tips.2021.90567.1087
Using a blend of herbal and synthetic polymers, the authors aim to extend the release of Sirolimus from the tablets. Sirolimus was used as a model drug, Hydroxy Propyl Methyl Cellulose was used as a synthetic polymer, and mucilage from Hibiscus rosa sinensis leaves was used as a natural polymer in this study. In addition to treating Lymphangioleiomyomatosis damage and suppressing body rejection toward transplanted organs, sirolimus is also an orphan drug. The Sirolimus matrix tablets are made with a combination of H. rosa sinensis leaf mucilage and Hydroxypropyl Methyl Cellulose. We assessed the flow properties of the blend and classified the designed tablets for official and non-official tests, including Sirolimus discharge. Sirolimus matrix tablets have passable pre- and post-formulation parameters with good Sirolimus content. A chemical interaction between Sirolimus and the polymers used in the study was not observed. Researchers also discovered that H. rosa sinensis leaf mucilage can be a good polymer in combination with other polymers for prolonged drug release.
Please cite this article as: Hindustan Abdul Ahad*1, Chinthaginjala Haranath1, Yarragunta Roja, Kandlapalli Swathi, Pandre shravya, Anam Rashi. A Tablet Matrix with Hibiscus Rosa Sinensis Leave Mucilage for Effective Treatment of Rare Lymphangioleiomyomatosis Using Sirolimus. Trends in Pharmaceutical Sciences. 2022;8(1):43-50.doi: 10.30476/TIPS.2021.90567.1087
Hibiscus rosa sinensis,Matrix,release,Sirolimus,Tablets
https://tips.sums.ac.ir/article_48019.html
https://tips.sums.ac.ir/article_48019_2ebb99fc0f3204b0332f3183bc9fd9b2.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
PCR based identification of exotoxin A-producing Pseudomonas aeroginosa isolated from burn wound infection
51
56
EN
Gholamreza
Morshedi
0000-0001-6069-9106
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences,
Zanjan, Iran.
rezamorshedi3116@gmail.com
Vahid
Ghanbarinejad
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
vahidghanbarinejad@gmail.com
Mina
Zareei
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences,
Shiraz, Iran
mina.zareei@yahoo.com
Abazar
Poornajaf
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
abazar_pournajaf@yahoo.com
Hossein
Hassanian-Moghaddam
0000-0003-4370-0544
Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
vahidghanbarinejd@gmail.com
Vahid
Hadi
Department of Biochemistry and Nutrition, Faculty of Medicine, AJA University of Medical Sciences,
Tehran, Iran.
vahidhadi1@gmail.com
Abbas
Isvand
Department of Food Quality Control Laboratory, Army Health Center of Excellence (NEZAJA), Tehran, Iran
isvand54@gmail.com
Mohammad reza
Saadati
Department of Food Quality Control Laboratory, Army Health Center of Excellence (NEZAJA), Tehran, Iran
mamalimrs978@gmail.com
Homayoun
Maleki
Department of Education and Research, Army Health Center of Excellence (NEZAJA), Tehran, Iran
ana.homayon@yahoo.com
Majid
Keshavarzi
0000-0002-0173-2233
Department of Environmental Health Engineering, School of Public Health, Sabzevar University of Medical
Sciences, Sabzevar, Iran
keshavarzi_majid@yahoo.com
10.30476/tips.2021.93218.1121
Exotoxin A (exoA) is a major pathogenic factor in Pseudomonas aeruginosa. This non-fermenting gram-negative bacillus causes a wide range of infections. P. aeruginosa is a major cause of hospital-acquired infections. With this view, this study was aimed to identify P. aeruginosa strains carrying the exoA gene isolated from burn wounds. As part of the cross-sectional study, 110 samples of burns were collected in several hospitals. After identification of bacterial strains by biochemical and microbiological tests, genomic DNA was extracted. PCR reaction was performed for screening for exoA gene. After examining DNA extracted using quantitative (Nano drop with OD260/280=1.8-2nm) and qualitative (electrophoresis on the 0.7% gel agarose) methods, 75.4% (n; 83 of 110) isolates carried the exoA gene. The high prevalence of the exoA gene in P. aeruginosa strains indicate the important role of this exoenzyme in the spread of infection in burn patients. Therefore, it is recommended that people with burn infections be screened for the exoA gene.
Please cite this article as: Gholamreza Morshedi, Vahid Ghanbarinejad, Mina Zarei, Abazar Pournajaf, Hossein <br />Hassanian-Moghaddam, Vahid Hadi,Abbas Isvand, Mohammad Reza Saadati, Homayoun Maleki, Majid Keshavarzi. PCR based identification of exotoxin A-producing Pseudomonas aeroginosa isolated from burn wound infection. Trends in Pharmaceutical Sciences. 2022;8(1):51-56 .doi: 10.30476/TIPS.2021.93218.1121
exotoxin A,Pseudomonas Aeruginosa,Burn Wound
https://tips.sums.ac.ir/article_48018.html
https://tips.sums.ac.ir/article_48018_02e4598293c82ab93d022f465c9750ff.pdf
Shiraz University of Medical Sciences
Trends in Pharmaceutical Sciences
2423-3722
2423-5652
8
1
2022
03
01
Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines
57
64
EN
Yemi
Adekunle
0000-0002-9392-3925
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ibadan University, Nigeria.
yemiadekunle03@yahoo.com
Babatunde
Samuel
0000-0001-5553-4438
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ibadan University, Nigeria.
tundebsamuel@gmail.com
Toluwanimi
Emmanuel
0000-0002-7202-8112
Department of Pharmacognosy, Faculty of Pharmacy, Ibadan University, Nigeria.
toluwanimiemmanuel@rocketmail.com
Johnson
Adeniji
0000-0002-0406-6707
WHO Polio Laboratory, Department of Virology, College of Medicine, badan University, Nigeria.
adek1808@yahoo.com
Omonike
Ogbole
0000-0002-6487-9494
Department of Pharmacognosy, Faculty of Pharmacy, Ibadan University, Nigeria.
nikeoa@yahoo.com
10.30476/tips.2022.94313.1136
The burden of cancer is alarmingly great on humans. However, the relevance of plants in combating cancer cannot be undermine. We joined the global search for anticancer agents from plants by screening nineteen (19) medicinal plant extracts on human breast carcinoma (MCF-7) and rhabdomyosarcoma (RD) cell lines using the 3- [4, 5-dimethylthiazol–2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Vincristine was used as the positive reference. Results were presented as mean IC50±standard error of the mean using GraphPad Prism (6.0). One-way ANOVA was used to establish the level of statistical significance. The results showed that twelve of the extracts were moderately cytotoxic on MCF-7 while seven were moderately active on RD (IC50, 30-100 µg/mL). Two of the extracts, Afzelia africana stem and Anogeissus leiocarpus root, showed significant activity on MCF-7 while seven had significant activity on RD (IC50 <br /> Please cite this article as: Yemi A. Adekunle, Babatunde B. Samuel*, Toluwanimi E Akinleye, Adekunle J. Adeniji, Omonike O. Ogbole. Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines. Trends in Pharmaceutical Sciences. 2022;8(1):57-64 .doi: 10.30476/TIPS.2022.94313.1136
Cytotoxicity,medicinal plants,Breast cancer,Rhabdomyosarcoma
https://tips.sums.ac.ir/article_48284.html
https://tips.sums.ac.ir/article_48284_a912c5c4397467ec095df1ca40c6f200.pdf