TY - JOUR ID - 42164 TI - Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study JO - Trends in Pharmaceutical Sciences JA - TIPS LA - en SN - 2423-3722 AU - Motazedian, Mohammad Hossein AU - Mohammadpour, Nilofar AU - Khabnadideh, Soghra AD - Basic Research in Infectious Diseases center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Parasitology, School of Medicine. Ahvaz University of Medical Sciences, Ahvaz Iran. AD - School of Pharmacy and pharmaceutical sciences research center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2015 PY - 2015 VL - 1 IS - 3 SP - 149 EP - 152 KW - Giardiasis KW - Treatment KW - Metronidazole DO - N2 - Giardiasis is a protozoal infection of small intestine caused by giardia lamblia. The disease is usually asymptomatic though it can present as acute or chronic diarrhea. Giardiasis is a major cause of intestinal infection and Iran is an endemic area of the disease. Despite reports about drug resistance, long course treatment and various side effects, metronidazole is the drug of choice for giardiasis.In this study we investigated in vivo effects of five new derivatives (a-e) of metronidazole (MTZ) on the giardia lamblia trophozoite in infected mice. Giardia intestinalis cysts were isolated from a patient and purified by sucrose gradient method. Fifty Purified cysts were inoculated to mice and after development of infection, the new metronidazole derivatives were given to the mice and results were compared to metronidazole as positive control.Compounds a and b showed desirable antigiardiasis activity and could destroy the cyst and trophozoite of giardia lamblia in mice after both two and four days, but the activity of the other compounds appeared only after 4 days. UR - https://tips.sums.ac.ir/article_42164.html L1 - https://tips.sums.ac.ir/article_42164_837a89a1db3cd12ccc35d12cec6daf44.pdf ER -