TY - JOUR ID - 42207 TI - Hepatoprotective effects of Artemia salina L. extract against carbon tetrachloride-induced toxicity JO - Trends in Pharmaceutical Sciences JA - TIPS LA - en SN - 2423-3722 AU - Mobasher, Mohammad Ali AU - Jamshidzadeh, Akram AU - Heidari, Reza AU - Ghahiri, Ghazal AU - Mobasher, Nazanin AD - Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Fars, Iran. AD - Y1 - 2016 PY - 2016 VL - 2 IS - 4 SP - 259 EP - 264 KW - Hepatotoxicity KW - CCl4 KW - Artemia salina L KW - Oxidative stress KW - HepG2 cells DO - N2 - The protective effects of Artemia salina L. extract was examined against carbon tetrachloride (CCl4)-induced cell toxicity. In the in vitro model of study, markers such as cell viability, cellular reduced and oxidized glutathione, and lipid peroxidation in HepG2 cells was evaluated. Human liver cancer cell line HepG2 was treated with CCl4 and Artemia salina extract, and markers of hepatotoxicity were investigated. Artemia salina extract showed significant dose-dependent protective effects against the cytotoxicity of CCl4. This extract was able to normalize the levels of GSH, and thiobarbituric acid-reactive (TBARs), which were altered due to CCl4 intoxication in HepG2 cells. As the oxidative stress markers were ameliorated, it might be concluded that Artemia salina extract possesses protective effects probably due to its antioxidant constituents. UR - https://tips.sums.ac.ir/article_42207.html L1 - https://tips.sums.ac.ir/article_42207_8b3964f2797112ac4c4f7cb457bf6d54.pdf ER -