2024-03-28T17:39:29Z
https://tips.sums.ac.ir/?_action=export&rf=summon&issue=4972
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
Recent findings in production and health benefits of prebiotics; a review of literatures
Abdorrasoul
Malekpour
Mehdi
Forouzesh
Saeid
Gholamzadeh
Younes
Ghasemi
Mohammad
Moaddeli
Prebiotics are known as fermented ingredient with specific health benefits. The two main fermentative substrates of dietary origin are non-digestible carbohydrates and proteins which escape digestion in the small intestine. Beside traditional protocols for production of prebiotics, there are some commercial advanced methods for mass production of prebiotics with acceptable health effects. On the other hand, different types of nondigestible oligosaccharides (NDO) are used in the food and drug industries as functional foods and nutraceuticals due to their prebiotic effects and also immunomodulation effects (ex. SCFA modulate chemokine expression in intestinal epithelial cells). Prebiotics with novel and wide variety of health benefits deal with a bright future for improving society health.
Prebiotics
production
Health Benefits
2018
12
01
197
204
https://tips.sums.ac.ir/article_44692_cf98d2b1552fe1ef0d9725dd295f3b2a.pdf
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
QSAR analysis of some azole derivatives as potent aromatase inhibitors
Razeih
Sabet
Soghra
Khabnadideh
Samaneh
Mohseni
Ayyub
Mojaddami
Zahra
Rezaei
A high proportion of breast tumors are hormone-dependent, implying that endogenous estrogens play a critical role in cancer cell proliferation. One of the most effective strategies for the treatment of breast cancer is reduction of estrogens level by inhibiting aromatase enzyme which is responsible for catalyzing the rate-limiting step in estrogen biosynthesis. A series of azole derivatives as potential aromatase inhibitors were subjected to two different drug design methodologies, QSAR and molecular docking simulation. MLR, FA-MLR, PCR and GA-PLS were employed to make connections between the structural parameters and aromatase inhibitory activity. GA-PLS represented superior results and a model with a high statistical quality (R2 = 0.86 and Q2 = 0.83) for predicting the inhibitory activity. The results can provide useful information for the development of more potent aromatase inhibitors.
QSAR
Aromatase inhibitor
Azole derivatives
2018
12
01
205
218
https://tips.sums.ac.ir/article_42266_386f2aa39f171cda0865e50ca004c573.pdf
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
Antimicrobial effect of some herbal medicine against infectious bacteria isolated from burn wound
Shahin
Mohammadsadeghi
Hasan
Habibi
Abdolkhalegh
Keshavarzi
Abdorrasoul
Malekpour
Herbal compounds with antimicrobial effects are of major considerations because of increasing antimicrobial resistance of pathogenic bacteria. In this study, we investigated the antimicrobial effects of Melissa officinalis L, Plantago major L, Orobancha crenata Forsk, Phoenix dactylifera, Ziziphus mauritiana and Teucrium Polium seed extracts on some human pathogenic bacteria isolated from burn wounds. Disk-diffusion antibiotic sensitivity testing, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were applied to assess the antibacterial activity of the extracts in comparison to the tetracycline, as a control antibiotic. The extract of the Orobancha crenata showed stonger antibacterial effects than the other herbal extracts on Pseudomonas aeroginosa and Kelebsiela ponomoni. Staphylococcus aureus was the most sensitive one to the Ziziphus mauritiana nucleus extract compared to other herbs. According to the results of this study, it can be concluded that extracts of some native plants of Iran can be appropriate alternative to the existing antibiotics, applicable for prevention of burn infections.
Melissa officinalis
Teucrium Polium
Burn infections
pathogenic bacteria
2018
12
01
219
224
https://tips.sums.ac.ir/article_44693_56ccaa3771e4f1aea9be1b6958788a40.pdf
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
Volatile Constituents and Antioxidant Activity of Spathes from Five Uncommon Varieties of Phoenix dactylifera L.
Mohammad Ali
Farbodniaye Jahromi
Mahmood Reza
Moien
Motahare
Mollaei
This study deals with characterization of chemical composition of spathe essential oil of five male varieties of Phoenix dactylifera L. including Ghir (GHI), Lar (LAR), Khosooyeh (KHO), Boyer (BOY) and Shahani (SHA). The essential oil samples were prepared through hydro-distillation using a Clevenger type apparatus. Analysis of oil samples was carried out following dehydration process. Hexane diluted samples were injected into a Gas chromatograph attached to a Mass spectrometer (GC/MS). Kovats indices (KI) was calculated for each compound and their mass fragmentation pattern were studied. The results compared with the relevant information procured from Wiley nl7 library and the Pherobase and NIST databases. Results of quantitative analysis of oil specimens indicated that, Ghir (0.03%) and Lar (0.07%) cultivars contain the lowest and the highest extraction yield of essential oil respectively. The oil samples were further screened for their DPPH free radical scavenging effects by means of a thin layer chromatographic method which showed a positive indication of anti DPPH activity through the visualization of spots and a yellow colour change on spraying the chromatoplates with a 0.2 % methanolic solution of DPPH. Results also indicated that 3,4-dimethoxytoluene is the main component in all Phoenix dactylifera L. spathe oil samples. This methoxylated aromatic compound showed the highest cocentration in Boyer (62.45%) and the lowest proportion in Khosooyeh cultivar (41.57%). Boyer spathe oil was superior in manifestation of DPPH free radical scavenging activity as compared with other cultivars.
2018
12
01
225
234
https://tips.sums.ac.ir/article_44719_c04e865abfacf137e63a02e0a3067e21.pdf
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
Toxicity of Hexyl Acrylate Modified PAMAM Dendrimer
Mohammad Ashkan
Naderian
Amin Reza
Akbarizadeh
Akram
Jamshidzadeh
Ali
Dehshahri
The aim of this study was to evaluate the effect of the hexyl acrylate conjugated polyamidoamine (PAMSM) dendrimer on different cell lines in the presence and absence of serum. Although the positively charged dendrimers including PAMAM has been considered as efficient gene carriers, their cytotoxicity is a major barrier for their clinical applications. The conjugation of hexyl acrylate on PAMAM dendrimer was carried out to improve the hydrophilic-hydrophiobic balance of the dendrimer as well as the modulation of the positive charge on the dendrimer structure. The cytotoxicity of PAMAM derivatives was evaluated using MTT test on HepG2, MCF-7 and A549 cell lines in the presence and absence of serum. The results revealed that the modified PAMAM dendrimers induced less toxic effects on the cell lines in the presence of serum. Therefore, conjugation of acrylate on the PAMAM structure could be an efficient way to reduce the dendrimer toxicity allowing the administration of more dendrimer for gene delivery.
2018
12
01
235
240
https://tips.sums.ac.ir/article_44721_ab27903795e02ab5ed2a05b6d7d72136.pdf
Trends in Pharmaceutical Sciences
2423-3722
2423-3722
2018
4
4
A retrospective and cross-sectional study to evaluate potential drug – drug interaction in hospitalized pediatrics, Bandar Abbas, Iran
Motahareh
Ahmadi
Abd
Nazemi
Seyedeh Fatemeh
Davoodpour
Fahimeh
Gharaie Pour
Maryam
Montaseri
Omid
Safa
AbstractBackground: The incidence of drug interactions in hospitalized patients due to the administration of various drugs, the lack of proper monitoring and sometimes multiple patient’s co-morbidities, is common. This study aims to evaluate potential drug-drug interactions (PDDIs) in pediatrics hospitalized in an educational pediatric hospital. Methods: The present study is a retrospective cross-sectional study. The study population included patients hospitalized in different parts of Bandar Abbas pediatrics hospital. A total of 400 medical records were assessed. PDDIs were evaluated by Lexi-Comp drug interaction and SPSS software was used for data analysis.Result: Based on our results PDDIs were observed in 133 cases (33.25%). The mean ± SD of PDDIs per prescription was 1.97 ± 1.56. The majority of the interaction were moderate (79.1%) with risk rating C (45.7%). Salbutamol, phenytoin, phenobarbital and clarithromycin were responsible for the most interactions with 95, 40, 25,17 of PDDIs, respectively. Drug interactions with risk-rating X, observed in 5 cases. Number of drugs per prescription was significantly associated with PDDIs (P= 0.000)Conclusion: Although the prevalence rate of PDDIs in this study was lower than reported by recent studies, but careful evaluation of drug charts and implantation of educational programs for medical staff, should be considered. Abbreviation PDDIs: Potential Drug-Drug InteractionsDDIs: Drug-Drug InteractionsED: Emergency departmentNICU: Neonatal Intensive Care UnitPICU: Pediatric Intensive Care Unit
2018
12
01
241
248
https://tips.sums.ac.ir/article_44720_08399f5ca845670f8190238884d49a7c.pdf