Trends in Pharmaceutical Sciences and Technologies

Trends in Pharmaceutical Sciences and Technologies

Electrochemical sensor based on multi-walled carbon nanotubes and 4-(((4-mercaptophenyl)imino)methyl) benzene-1,2-diol for simultaneous determination of epinephrine in the presence of acetaminophen

Document Type : Research(Original) Article

Authors
Roghayyeh Aghaei
Mohammad Mazloum-Ardakani
Mohammad Abdollahi-Alibeik
Ali Moaddeli
Abstract
A carbon paste electrode modified with 4-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (MIB) and multi-walled carbon nanotubes MIB /CNT/CPE) was prepared for determination of epinefrine (EP) in the presence of acetaminophen (AC). Cyclic voltammetry, chronoamperometry and differential pulse voltammetry (DPV) techniques were used to investigate the modified electrode for the electrocatalytic oxidation of (EP) and (AC) in aqueous solutions. The separation of the oxidation peak potential for EP- AC was 200 mV. Under the optimum conditions, the calibration curve for EP was obtained in the range of 1.0 to 25.0 µM and 25.0 to 500.0 µM. The diffusion coefficient for the oxidation of EP at the surface of modified electrode was calculated as 5.76×10-5 cm2s-1.
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Trends in Pharmaceutical Sciences and Technologies
Volume 4, Issue 3 - Serial Number 3
17
September 2018
Pages 139-148