Evaluation of Intravenous immunoglobulin usage pattern in an educational hospital, a descriptive-cross sectional study, Bandar Abbas, IRAN

Ahmadi, Motahareh; Safa, Omid; Nazemi, Abd; Doorandish, Bahram; Gharaie Pour, Fahimeh; Montaseri, Maryam

doi:10.30476/tips.2019.82124.1010

Evaluation of Intravenous immunoglobulin usage pattern in an educational hospital, a descriptive-cross sectional study, Bandar Abbas, IRAN

Document Type : Original Article

Authors

Motahareh Ahmadi ¹

Omid Safa ²

Abd Nazemi ³

Bahram Doorandish ⁴

Fahimeh Gharaie Pour ²

Maryam Montaseri ⁵

¹ Hormozgan University of Medical Sciences

² Department of Clinical Pharmacy, Faculty of Pharmacy , Hormozgan University of Medical Sciences, Bandar Abbas , Hormozgan , Iran

³ Pediatric Hospital, Hormozgan University of Medical Sciences, Bandar Abbas , Hormozgan , Iran

⁴ Faculty of Pharmacy , Hormozgan University of Medical Sciences, Bandar Abbas , Hormozgan , Iran

⁵ Instructor of Biostatistics , Department of Public Health , Faculty of Health , Hormozgan University of Medical Sciences, Bandar Abbas , Hormozgan , Iran

10.30476/tips.2019.82124.1010

Abstract

Introduction: The goal of DUE is to improve patients’ care. Studying the administration and utilization pattern of IVIg is an important research topic due to its significant role in the treatment and control of many disorders, high prices, and limited availability. We aimed to evaluate the pattern of IVIg use in an educational hospital.
Material and methods: In this descriptive-cross sectional and retrospective study, 250 patients’ records included medical orders, nursing notes and drug chart were studied. We used FDA and UK protocol to evaluate of IVIg indications in our study. Data were analyzed using SPSS software.
Results: Prescription of IVIg in our hospital adhered to FDA- approved indications and red indications of UK guideline with 64.1% and 67.6%, respectively. ITP was the most common cause of the correct prescriptions (52.7% based on FDA guideline and 50% based on UK guideline). Sepsis (15.5%), hyperbillirubinemia (10.4%), encephalitis (3.5%), and aplastic anemia (1.38%) were incorrect indications of IVIg in our study. ADRs was observed in 14.5% of patients.
Discussions: Consumption of IVIg in our hospital, was more consistent with international guidelines compared with other hospitals in IRAN, of course unnecessary prescriptions cannot be ignored. We suggest to develop own national guideline and educate our prescribers to minimize irrational prescription of expensive and important medicines such as IVIg.

Keywords

Drug Utilization Evaluation

Intravenous Immunoglobulin

Inpatient