The association between Helicobacter pylori eradication in peptic ulcer patients and gastric cancer? Investigation in an East-Asian population

Document Type: Breif Report


Mashhad univ med sci



H. pylori is Gram-negative, microaerophilic, and motile bacteria which colonized in human stomach of nearly 50% of world population; there are several evidence for chronic colonization with H. pylori that significantly increased the risk of gastric cancer development (15). Eradication of H. pylori infection can have reduced the risk of gastric cancer as well as reduction of H. pylori in young population as reservoir of infection (5,10). According to literatures, the mother to child transmission is predominant rout of H. pylori transmission in Japanese population; therefore, eradication of H. pylori infection can be considered as appropriated strategy for reducing both of gastric cancer as well as H. pylori infection burden (16). There are several literatures in relation to efficacy of H. pylori eradication for prevention of gastric cancer development in asymptomatic carrier and patients with endoscopic resections (7,8); however, we evaluated the efficacy of H. pylori eradication in reduction of gastric cancer in patients with history of peptic ulcer. We are suggested that H. pylori infection should be eradicated in peptic ulcer patients in order to reducing the risk of develop to gastric cancer.