The therapeutic potential of trifluoperazine against ethanol and cold water stress-induced gastric lesions in rat

Document Type : Original Article

Authors

1 Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Food and Supplements Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Medicinal Plants Processing, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Medicinal Chemistry, Shiraz University of Medical Sciences, Shiraz, Iran.

5 Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/tips.2021.92622.1112

Abstract

PurposeGastric erosion is a multifactorial etiological disorder. The study aimed to evaluate the therapeutic effect of trifluoperazine (TFP ) on gastric lesioninduced by cold-water stress and ethanol in rats.
MethodsTFP 5, 10 and 20 mg/kg as well aspantoprazole (20 mg/kg), as the standard treatment, was administered via oral gavage, 1 h before gastric lesion-induced by 50% ethanol (5 ml/kg per oral) or immersion in cold water (20-22°C) in rats. Animals were anesthetized 1h after ethanol gavage or 4 h after immersion in cold water. The stomach tissue was removed and allocated for histopathologicalandbiochemical parameters including malondialdehyde level, superoxide dismutase and catalase activity assay.
ResultsBoth models wereinduced with a significant increase in the MDA level and a decrease in the SOD and CAT activity. Pre-treatment with TFP at doses of 10 and 20 mg/kg significantly increased the activity of SOD and CAT enzymes and decreased the concentration of MDA in both models. Also,pre-treatment with TFP ameliorated ethanol and cold-water stress-induced damage.
ConclusionTFP demonstrated gastric mucosal protection against oxidative injuries caused by ethanol and cold-water stress because of its antioxidant properties and inhibition of toxic oxidant in the stomach tissues.

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