STOMACH SPECIFIC LOW DENSITY FLOATING MICROBALLOONS FOR EXTENDED DELIVERY OF RHYNCHOSIA DENSIFLORA EXTRACT IN THE TREATMENT OF PEPTIC ULCER

Document Type : Original Article

Authors

1 Department of Pharmacology, Faculty of Pharmacy, M S. Ramaiah University of Applied Sciences, MSR Nagar

2 Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India

3 Department of Pharmacognosy, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India

4 Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India

10.30476/tips.2021.93365.1124

Abstract

Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of Rhynchosia densiflora (Roth) DC leaves was prepared by Soxhlet extraction and subjected to phytochemical analysis. Microballoons loaded with ethanolic extract of Rhynchosia densiflora leaf were developed by solvent evaporation method and characterized by optical microscopy, floating time, and release characteristics. Acute oral toxicity study of microballons was carried out following OECD guidelines 423 and antiulcer activity was performed by pylorus ligation, indomethacin and cystamine induced duodenal ulcer methods.. Rhynchosia densiflora extract was found to contain glycosides, proteins, flavonoids, phenolic compounds, tannins and saponins. The particle size of microballoons of Rhynchosia densiflora extract was found to be in the range of 300μm. Acute toxicity studies of microballoons did not produce any toxic symptoms and mortality in animals, hence 100 and 200mg/kg concentrations were selected to screen antiulcer activity. Both the doses showed significant gastric ulcer healing effect and gastric antisecretory effect in pylorus ligated rats, gastric cytoprotective effect in indomethacin induced gastric ulcer and also produced a significant reduction in duodenal ulcers. Dose of 200mg/kg showed highly significant antiulcer activity than 100mg/kg. Thus, it is concluded that floating microballoons loaded with Rhynchosia densiflora extract significantly reduced gastric acid secretion, increased healing of gastric ulcers and also prevent the duodenal ulcers in rats.

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