The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Options: A Brief Review

Document Type : Review Article


1 Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

3 School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

4 School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

5 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.


Acne vulgaris is a chronic multifactorial skin disease that millions of people around the world of suffering from that. Pathophysiology of acne consists of several mechanisms including hyper-seborrhea, hyperkeratinization of pilosebaceous units, increased bacterial proliferation, hyperandrogenism, alteration in sebum contents, and inflammatory processes. In this regard, consideration of the main causes of acne development and severity of acne lesions in the selection of suitable pharmacologic agents is essential. In this review, among the other factors, the role of the different lipids in pathophysiology of acne were considered. The common sources of skin lipids have been categorized into two main categories including endogenous and exogenous sources. Furthermore, the role of different factors including lipids and fatty acids, androgens, microorganisms, cosmeceuticals, and lipids oxidation and peroxides in acne vulgaris development have been summarized. In the end, the necessity of the choice of appropriate pharmacotherapy regimens and recruitment of novel drug delivery systems in acne management have been mentioned. 
Please cite this article as: Parisa Ghasemiyeh, Kiarash Noorizadeh, Dorsa Dehghan, Shiva Rasekh, Ouriel Zadmehr, Soliman Mohammadi-Samani. The Role of Different Factors in Pathophysiology of Acne and Potential Therapeutic Targets: A Brief Review. Trends in Pharmaceutical Sciences. 2022;8(2):107-118. doi: 10.30476/TIPS.2022.95146.1142


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