Solid-phase nano extraction as a green approach for the analyte isolation

Document Type : Review Article


1 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

2 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


Today rapid and reliable analytical method for determining the trace level of targeted analytes in biological analysis and different fields is an essential object in analysis. So we try to focus on novel methods suggested for improving solid-phase microextraction based on novel drug delivery systems, especially nanoparticles. Nanoparticles like (dendrimer, carbon-based nanoparticles, magnetic and mesoporous nanoparticles, …) and their application as a new sorbent combined with different methods such as solid microextraction and liquid microextraction techniques are discussed in this article. These nano sorbents induced the potentials like selectivity and sensitivity for these methods. Furthermore, this nano extraction caused the lower consumption of hazardous solvent and reduced the total time needed for the extraction procedure, especially in biological analysis. The beneficial effects of nanoparticles indicated that a meaningful future was expected for their application. These new sorbents can be evolved the analytical methods and create reliable and rapid analytical methods.     


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