Document Type : Original Article
Authors
1
Department of phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medica
2
Student Research Committee, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
10.30476/tips.2025.104471.1264
Abstract
Considering the importance of pain, this study aims to present a standard topical formulation for pain control. In the texts of traditional Persian pharmaceutical books, many verbs, and citrus fruits are mentioned as pain relievers. In this study, the Plantago ovata Forssk. plant was selected from the book of Makhzen al-Adviyah, and related aqueous and acidic extractions were yielded in rose oil. After microscopic characterization and determining the identification number of the plant, Plantago ovata seed extract was prepared with different acidic and aqueous types, and the mucilage was prepared after evaluating several cream formulations, finally, the proportion of 65% oil and 35% stearic acid contained 0.7% extract. It was chosen as the appropriate formulation, which was more suitable for appearance characteristics (uniform texture and proper spreading without feeling rough on the skin). The final semi-solid formulation was examined in terms of the uniformity and integrity of the cream and the examination of rubability and cream consistency tests, the examination of spreadability, pH measurement, and the examination of viscosity and rheology properties, and the results showed that this formulation in terms of pharmaceutics tests and the total saccharide content was in the acceptable range. After passing the clinical trials, the mentioned product can be effective as a product derived from herbal compounds for pain control.
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