Document Type : Review Article
Authors
1
Phytopharmaceutical Technology and Traditional Medicine Incubator
2
Department of Phytopharmaceuticals, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3
School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
10.30476/tips.2025.105864.1284
Abstract
Rydingia persica (Burm.f.) Scheen & V.A.Albert is an endemic plant known for its use in Iranian folk medicine. The decoction made from the roots and aerial parts of R. persica has been traditionally utilized for its anti-diabetic properties in Iran. This study aims to highlight the ethnomedicinal, pharmacological, and anti-diabetic activities of R. persica. The review encompasses clinical, in vivo, and in vitro studies related to diabetes and its complications. A comprehensive literature search was conducted across various scientific databases, including PubMed, Scopus, ISI-Web of Science, and the local Iranian database IRANDOC. Relevant articles were identified using keywords "Rydingia persica," "Otostegia persica," "ShekarShafa," "Goldar/Golder," and "Gol-Khaarou," covering studies published from the inception up to 2024. Pharmacological studies on R. persica indicate significant anti-diabetic potential. Various extracts from the plant, especially its aerial parts, have demonstrated anti-hyperglycemic, anti-hyperlipidemic, and antioxidant effects in both in vitro and in vivo studies. Key phytochemicals, including quercetin, caffeic acid, and isorhamnetin have been identified as major contributors to these effects. The extracts of the plant have shown promising results in lowering blood glucose levels, improving insulin sensitivity, and reducing oxidative stress. Furthermore, R. persica has demonstrated protective effects on vital organs, including the liver and kidneys, in animal models. Despite these encouraging findings, clinical studies involving human participants remain limited. Only one trial has reported insignificant effects from a methanol extract of the leaves. Therefore, further research, particularly clinical trials, is needed to validate the therapeutic potential of R. persica for managing diabetes.
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