Atorvastatin loaded PVA/alginate fibers as a potential wound dressing

Document Type : Original Article

Authors

1 Department of Pharmaceutics, School of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.

2 Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

10.30476/tips.2025.106250.1290

Abstract

Wound healing is a complex process that involves cellular and biochemical aspects. Many effective methods and formulations for wound healing have been reported in the studies. Hydrogels containing biodegradable and biocompatible polymers have shown significant effectiveness in wound healing process. Atorvastatin, an effective drug in the wound healing process, accelerates healing through impacting on various stages. In this study, a fiber was formed of two biocompatible polymers, sodium alginate and polyvinyl alcohol, with an optimized concentration of 1.2% and 10%, respectively. The drug was added to the initial polymer solution at a concentration of 1% and was simultaneously electrospun. Glutaraldehyde was used as cross-linker to enhance the physical characteristics of fiber. The fibers were subjected to strength and release assays. The prepared fiber exhibited smooth and uniform three-dimensional structure with proper strength. Atorvastatin was released within 30 minutes. Based on the results obtained, the proposed fiber could potentially be used in wound dressing membranes.

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