A Glimpse into the Pathophysiology, Classification, Clinical Presentations, and Management of Psoriasis

Document Type : Review Article

Authors

1 Department of phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medica

2 Shiraz University of Medical Sciences

10.30476/tips.2025.106092.1288

Abstract

The skin and dermatological diseases have a considerable potential to impact a person's social conduct, self-esteem, and willingness to engage in social interactions. The burden of skin diseases includes both their high incidence and the long-term morbidity associated with them. Psoriasis is the most prevalent immune-mediated inflammatory disease worldwide and is a multifactorial skin condition that arises from the interaction of immunological, genetic, and environmental factors. Numerous comorbidities, such as psoriatic arthritis, inflammatory bowel disease, metabolic syndromes, and complications related to respiratory, cardiovascular, and mental health, are associated with chronic psoriasis. There are several forms of cutaneous psoriasis. Psoriasis vulgaris is the most common phenotype, accounting for about 85–90% of psoriasis cases. Based on the clinical severity of the lesions, patients with psoriatic disease can be categorized as having mild, moderate, or severe disease. This review highlights various psoriasis presentations, related clinical signs and symptoms, and the available treatment options.

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