Release of profens from nanofibers: Challenges and opportunities

Document Type : Review Article

Authors

1 Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran.

2 The Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

Abstract

Nanofibrous meshes refer to the structures made of ultra-fine polymeric fibers. Because of nanometer measure size with an excessive strength/weight ratio, they are actual suitable as a nanosystem for delivering drug molecules. Drug molecules which mixed in nanofibers, can be released from the surrounding environment by means of various mechanisms in different manners (burst release, sustainable release and tunable release). Nanofibers can be used by way of release rate controlling strategies as proper delivery structures for drug molecules.The objective of this review is to highpoint the capacity of nanofibers as novel releasing substances for profens (Propionic acid derivative drugs including Carprofen; Naproxen; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen and Tiaprofenic acid). The profens are a class of nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs). These drug molecules are derivatives of 2-phenylpropanoic acid. All contain a chiral center resulting in the formation of two enantiomers (R and S) of each profen.
In this review, full information will be reported about the new progresses for release behaviors of profen molecules form the novel nanofibrous delivery systems. The drug releasing kinetics of profen molecules from nanofibers will be described briefly. The authors use more than 80 articles , books and thesis published in the case of nanofibrous profens delivery and releasing systems.

Keywords

References

1. Doostmohammadi M, Forootanfar H, Ramakrishna S. Regenerative medicine and drug delivery: Progress via electrospun biomaterials. Mater Sci Eng: C. 2020;109:110521.
2. Celebioglu A, Uyar T. Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system. RSC Med Chem. 2020;11(2):245-258. Published 2020 Jan 8. doi:10.1039/c9md00390h
3. Nagiah N, Murdock CJ, Bhattacharjee M, Nair L, Laurencin CT. Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications. Sci Rep. 2020;10 (1):609.
4. Sofi HS, Abdal-hay A, Ivanovski S, Zhang YS, Sheikh FA. Electrospun nanofibers for the delivery of active drugs through nasal, oral and vaginal mucosa: Current status and future perspectives. Mater Sci Eng: C. 2020;111:110756.
5. Guo H, Tan S, Gao J, Wang L. Sequential release of drugs form a dual-delivery system based on pH-responsive nanofibrous mats towards wound care. J Mater Chem B. 2020;8(8):1759-1770.
6. Contreras-Cáceres R, Cabeza L, Perazzoli G, Díaz A, López-Romero JM, Melguizo C, et al. Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy. Nanomaterials (Basel). 2019 Apr 24;9(4):656. doi: 10.3390/nano9040656. PMID: 31022935; PMCID: PMC6523776.
7. Kajdič S, Zupančič Š, Roškar R, Kocbek P. The potential of nanofibers to increase solubility and dissolution rate of the poorly soluble and chemically unstable drug lovastatin. Int J Pharm. 2020 Jan 5;573:118809. doi: 10.1016/j.ijpharm.2019.118809. Epub 2019 Oct 31. PMID: 31678525.
8. Gupta P, Purwar R. Electrospun pH responsive poly (acrylic acid-co- acrylamide) hydrogel nanofibrous mats for drug delivery. J Polym Res. 2020;27 (10):296.
9. Yang J, Wang K, Yu D-G, Yang Y, Bligh SWA, Williams GR. Electrospun Janus nanofibers loaded with a drug and inorganic nanoparticles as an effective antibacterial wound dressing. Mat Sci Eng: C. 2020;111:110805.
10. Cleeton C, Keirouz A, Chen X, Radacsi N. Electrospun Nanofibers for Drug Delivery and Biosensing. ACS Biomater Sci Eng. 2019 Sep 9;5(9):4183-4205. doi: 10.1021/acsbiomaterials.9b00853. Epub 2019 Aug 23. PMID: 33417777.
11. Tort S, Han D, Steckl AJ. Self-inflating floating nanofiber membranes for controlled drug delivery. Int J Pharm. 2020;579:119164.
12. Sa’adon S, Abd Razak SI, Ismail AE, Fakhruddin K. Drug-Loaded Poly-Vinyl Alcohol Electrospun Nanofibers for Transdermal Drug Delivery: Review on Factors Affecting the Drug Release. Procedia Comput Sci. 2019;158:436-442.
13. Khodadadi M, Alijani S, Montazeri M, Esmaeilizadeh N, Sadeghi-Soureh S, Pilehvar-Soltanahmadi Y. Recent advances in electrospun nanofiber-mediated drug delivery strategies for localized cancer chemotherapy. J Biomed Mater Res. 2020;108 (7):1444-1458.
14. Kharaghani D, Gitigard P, Ohtani H, Kim KO, Ullah S, Saito Y, Khan MQ, Kim IS. Design and characterization of dual drug delivery based on in-situ assembled PVA/PAN core-shell nanofibers for wound dressing application. Sci Rep. 2019;9 (1):12640.
15. Huang CK, Zhang K, Gong Q, Yu DG, Wang J, Tan X, Quan H. Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning. Int J Biol Macromol. 2020 Jun 1;152:68-76. doi: 10.1016/j.ijbiomac.2020.02.239. Epub 2020 Feb 22. PMID: 32097744.
16. Tavanaie MA. Drug Delivery of Nanofibers Based on Biodegradable Synthetic Polymer Blends: A Review. Basparesh. 2017;7 (2):13-29.
17. Yan E, Jiang J, Yang X, Fan L, Wang Y, An Q, Zhang Z, Lu B, Wang D, Zhang D. pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer. J Drug Deliv Sci Technol. 2020;55:101455.
18. Yang Y, Chang S, Bai Y, Du Y, Yu D-G. Electrospun triaxial nanofibers with middle blank cellulose acetate layers for accurate dual-stage drug release. Carbohydr Polym. 2020;243:116477.
19. Hou J, Yang J, Zheng X, Wang M, Liu Y, Yu D-G. A nanofiber-based drug depot with high drug loading for sustained release. Int J Pharm. 2020;583:119397.
20. Jain R, Shetty S, Yadav KS. Unfolding the electrospinning potential of biopolymers for preparation of nanofibers. J Drug Deliv Sci Technol. 2020;57:101604.
21. Sun Y, Cheng S, Lu W, Wang Y, Zhang P, Yao Q. Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization. RSC Adv. 2019;9 (44):25712-25729.
22. Ismail HM, Ali-Adib S, Younes HM. Reactive and functionalized electrospun polymeric nanofibers for drug delivery and tissue engineering applications. Ther Deliv. 2019 Jul;10(7):397-399. doi: 10.4155/tde-2019-0028. Epub 2019 Jul 15. PMID: 31304876.
23. Moydeen AM, Ali Padusha MS, Aboelfetoh EF, Al-Deyab SS, El-Newehy MH. Fabrication of electrospun poly(vinyl alcohol)/dextran nanofibers via emulsion process as drug delivery system: Kinetics and in vitro release study. Int J Biol Macromol. 2018;116:1250-1259.
24. Unnithan AR, Sasikala AR, Murugesan P, Gurusamy M, Wu D, Park CH, et al. Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing. Int J Biol Macromol. 2015;77:1-8. doi: 10.1016/j.ijbiomac.2015.02.044. Epub 2015 Mar 5. PMID: 25748849.
25. Faraji Dizaji B, Hasani Azerbaijan M, Sheisi N, Goleij P, Mirmajidi T, Chogan F, Irani M, Sharafian F. Synthesis of PLGA/chitosan/zeolites and PLGA/chitosan/metal organic frameworks nanofibers for targeted delivery of Paclitaxel toward prostate cancer cells death. Int J Biol Macromol. 2020;164:1461-1474.
26. Tuğcu-Demiröz F, Saar S, Tort S, Acartürk F. Electrospun metronidazole-loaded nanofibers for vaginal drug delivery. Drug Dev Ind Pharm. 2020 Jun;46(6):1015-1025. doi: 10.1080/03639045.2020.1767125. Epub 2020 May 25. PMID: 32393132.
27. Göttel B, de Souza e Silva JM, Santos de Oliveira C, Syrowatka F, Fiorentzis M, Viestenz A, Viestenz A, Mäder K. Electrospun nanofibers – A promising solid in-situ gelling alternative for ocular drug delivery. Eur J Pharm Biopharm. 2020;146:125-132.
28. Farokhi M, Mottaghitalab F, Reis RL, Ramakrishna S, Kundu SC. Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges. J Control Release. 2020 May 10;321:324-347. doi: 10.1016/j.jconrel.2020.02.022. Epub 2020 Feb 13. PMID: 32061791.
29. Zandi N, Lotfi R, Tamjid E, Shokrgozar MA, Simchi A. Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110432. doi: 10.1016/j.msec.2019.110432. Epub 2019 Nov 15. PMID: 31923974.
30. Meneguin AB, da Silva Barud H, Sábio RM, de Sousa PZ, Manieri KF, de Freitas LAP, Pacheco G, Alonso JD, Chorilli M. Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery. Carbohydr Polym. 2020;249:116838.
31. Khalili Amand F, Esmaeili A. Investigating the properties of electrospun nanofibers made of hybride polymer containing anticoagulant drugs. Carbohydr Polym. 2020;228:115397.
32. Jiang Y-N, Mo H-Y, Yu D-G. Electrospun drug-loaded core–sheath PVP/zein nanofibers for biphasic drug release. Int J Pharm. 2012;438 (1):232-239.
33. Day RO, Graham GG, Williams K. Propionic Acid Derivative Drugs (Profens). In: Parnham MJ, ed. Compendium of Inflammatory Diseases. Basel: Springer Basel; 2016:1106-1110.
34. Duggan KC, Hermanson DJ, Musee J, et al. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat Chem Biol. 2011;7(11):803-809. doi:10.1038/nchembio.663
35. Mao Y, Chen M, Guidoin R, Li Y, Wang F, Brochu G, Zhang Z, Wang L. Potential of a facile sandwiched electrospun scaffold loaded with ibuprofen as an anti-adhesion barrier. Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111451. doi: 10.1016/j.msec.2020.111451. Epub 2020 Aug 27. PMID: 33255038.
36. Chen CT, Chen CH, Sheu C, Chen JP. Ibuprofen-Loaded Hyaluronic Acid Nanofibrous Membranes for Prevention of Postoperative Tendon Adhesion through Reduction of Inflammation. Int J Mol Sci. 2019 Oct 11;20(20):5038. doi: 10.3390/ijms20205038. PMID: 31614502; PMCID: PMC6834315.
37. Xu Y, Li JJ, Yu DG, Williams GR, Yang JH, Wang X. Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior. Eur J Pharm Sci. 2017 Aug 30;106:422-430. doi: 10.1016/j.ejps.2017.06.017. Epub 2017 Jun 11. PMID: 28614732.
38. Jamshidi-Adegani F, Seyedjafari E, Gheibi N, Soleimani M, Sahmani M. Prevention of adhesion bands by ibuprofen-loaded PLGA nanofibers. Biotechnol Prog. 2016 Jul 8;32(4):990-7. doi: 10.1002/btpr.2270. Epub 2016 Aug 3. PMID: 27061396.
39. Yu D-G, Zhang X-F, Shen X-X, Brandford-White C, Zhu L-M. Ultrafine ibuprofen-loaded polyvinylpyrrolidone fiber mats using electrospinning. Polym Int. 2009;58 (9):1010-1013.
40. Shi Y, Wei Z, Zhao H, Liu T, Dong A, Zhang J. Electrospinning of ibuprofen-loaded composite nanofibers for improving the performances of transdermal patches. J Nanosci Nanotechnol. 2013 Jun;13(6):3855-63. doi: 10.1166/jnn.2013.7157. PMID: 23862418.
41. Chen S, Wang G, Wu T, et al. Silver nanoparticles/ibuprofen-loaded poly(L-lactide) fibrous membrane: anti-infection and anti-adhesion effects. Int J Mol Sci. 2014;15(8):14014-14025. Published 2014 Aug 12. doi:10.3390/ijms150814014
42. Tran T, Hernandez M, Patel D, Burns E, Peterman V, Wu J. Controllable and switchable drug delivery of ibuprofen from temperature responsive composite nanofibers. Nano Convergence. 2015;2 (1):15.
43. Liu S, Hu C, Li F, Li XJ, Cui W, Fan C. Prevention of peritendinous adhesions with electrospun ibuprofen-loaded poly(L-lactic acid)-polyethylene glycol fibrous membranes. Tissue Eng Part A. 2013;19(3-4):529-37.
44. Mohiti-Asli M, Saha S, Murphy SV, Gracz H, Pourdeyhimi B, Atala A, Loboa EG. Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo. J Biomed Mater Res B Appl Biomater. 2017 Feb;105(2):327-339. doi: 10.1002/jbm.b.33520. Epub 2015 Oct 28. PMID: 26509902.
45. Shi Y, Xu S, Dong A, Zhang J. Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats. J Mater Sci Mater Med. 2013 Feb;24(2):333-41. doi: 10.1007/s10856-012-4805-1. Epub 2012 Nov 9. PMID: 23138838.
46. Potrč T, Baumgartner S, Roškar R, Planinšek O, Lavrič Z, Kristl J, Kocbek P. Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs. Eur J Pharm Sci. 2015 Jul 30;75:101-13. doi: 10.1016/j.ejps.2015.04.004. Epub 2015 Apr 21. PMID: 25910438.
47. Gao Y, Teoh TW, Wang Q, Williams GR. Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems. J Mater Chem B. 2017;5 (46):9165-9174.
48. Li Z, Kang H, Che N, Liu Z, Li P, Li W, et al. Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers. Carbohydr Polym. 2014 Oct 13;111:18-24. doi: 10.1016/j.carbpol.2014.04.017. Epub 2014 Apr 18. PMID: 25037324.
49. Yu D-G, Branford-White C, Shen X-X, Zhang X-F, Zhu L-M. Solid Dispersions of Ketoprofen in Drug-Loaded Electrospun Nanofibers. J Dispers Sci Technol. 2010;31 (7):902-908.
50. Kenawy E-R, Abdel-Hay FI, El-Newehy MH, Wnek GE. Controlled release of ketoprofen from electrospun poly(vinyl alcohol) nanofibers. Mater Sci Engin: A. 2007;459 (1):390-396.
51. Wen S, Hu Y, Zhang Y, Huang S, Zuo Y, Min Y. Dual-functional core-shell electrospun mats with precisely controlled release of anti-inflammatory and anti-bacterial agents. Mater Sci Eng C Mater Biol Appl. 2019 Jul;100:514-522. doi: 10.1016/j.msec.2019.02.076. Epub 2019 Feb 23. PMID: 30948088.
52. Sta M, Aguiar G, Forni AAJ, Medeiros SF, Santos AM, Demarquette NR. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs. J Appl Polym Sci. 2020;137 (11):48472.
53. Zhu T, Chen S, Li W, Lou J, Wang J. Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)–nanopoly(lactic-co-glycolic acid) core–shell composite nanofibers: Preparation, characterization, and anti-adhesion activity. J Appl Polym Sci. 2015;132 (22).
54. Minisy IM, Salahuddin NA, Ayad MM. In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers. Polym Bull. 2020.
55. Lee H, Xu G, Kharaghani D, Nishino M, Song KH, Lee JS, et al. Electrospun tri-layered zein/PVP-GO/zein nanofiber mats for providing biphasic drug release profiles. Int J Pharm. 2017 Oct 5;531(1):101-107. doi: 10.1016/j.ijpharm.2017.08.081. Epub 2017 Aug 19. PMID: 28830784.
56. Vrbata P, Berka P, Stránská D, Doležal P, Musilová M, Čižinská L. Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int J Pharm. 2013 Nov 30;457(1):168-76. doi: 10.1016/j.ijpharm.2013.08.085. Epub 2013 Sep 16. PMID: 24050988.
57. Riggin CN, Qu F, Kim DH, Huegel J, Steinberg DR, Kuntz AF, Soslowsky LJ, Mauck RL, Bernstein J. Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation. Ann Biomed Eng. 2017 Oct;45(10):2348-2359. doi: 10.1007/s10439-017-1876-7. Epub 2017 Jun 26. PMID: 28653294; PMCID: PMC5831397.
58. Godakanda VU, Li H, Alquezar L, Zhao L, Zhu L-M, de Silva R, de Silva KMN, Williams GR. Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers. Int J Pharm. 2019;562:172-179.
59. Liu Y, Nguyen A, Allen A, Zoldan J, Huang Y, Chen JY. Regenerated cellulose micro-nano fiber matrices for transdermal drug release. Mater Sci Engin: C. 2017;74:485-492.
60. Tarlani A, Isari M, Khazraei A, Eslami Moghadam M. New sol-gel derived aluminum oxide-ibuprofen nanocomposite as a controlled releasing medication. Nanomedi Res J. 2017;2 (1):28-35.
61. Raimi-Abraham BT, Mahalingam S, Davies PJ, Edirisinghe M, Craig DQ. Development and Characterization of Amorphous Nanofiber Drug Dispersions Prepared Using Pressurized Gyration. Mol Pharm. 2015 Nov 2;12(11):3851-61. doi: 10.1021/acs.molpharmaceut.5b00127. Epub 2015 Oct 6. PMID: 26402331.
62. Nabipour Z, Nourbakhsh MS, Baniasadi M. Evaluation of Ibuprofen Release from Gelatin /Hydroxyapatite /Polylactic Acid Nanocomposites. Iran J Pharm Sci. 2018;14 (1):75-84.
63. Mao Y, Chen M, Guidoin R, Li Y, Wang F, Brochu G, et al. Potential of a facile sandwiched electrospun scaffold loaded with ibuprofen as an anti-adhesion barrier. Mater Sci Eng C. 2021;118:111451.
64. Qirui H, Xiang LQ. Synthesis of Electrospun Zein and Silk Fibroin/Zein Meshes with Ibuprofen for Drug Delivery to Chronic Wounds. Thesis, 2018.
65. SATRIAWAN NE. Sintesis Dan Karakterisasi Nanofiber Selulosa Asetat Penambahan Ibuprofen Sebagai Model Sistem Penghantar Obat. Thesis , Universitas Airlangga, 2017.
66. Batool F, Morand DN, Thomas L, Bugueno IM, Aragon J, Irusta S, et al. Synthesis of a Novel Electrospun Polycaprolactone Scaffold Functionalized with Ibuprofen for Periodontal Regeneration: An In Vitro andIn Vivo Study. Materials (Basel). 2018 Apr 10;11(4):580. doi: 10.3390/ma11040580. PMID: 29642582; PMCID: PMC5951464.
67. Yuan Z, Zhao J, Zhu W, Yang Z, Li B, Yang H, et al. Ibuprofen-loaded electrospun fibrous scaffold doped with sodium bicarbonate for responsively inhibiting inflammation and promoting muscle wound healing in vivo. Biomater Sci. 2014;2 (4):502-511.
68. Wang L, Chen D, Sun J. Layer-by-layer deposition of polymeric microgel films on surgical sutures for loading and release of ibuprofen. Langmuir. 2009 Jul 21;25(14):7990-4. doi: 10.1021/la9004664. PMID: 19326871.
69. Yuan Z, Zhao J, Yang Z, Li B, Yang H, Cui W, et al. Synergistic Effect of Regeneration and Inflammation via Ibuprofen-Loaded Electrospun Fibrous Scaffolds for Repairing Skeletal Muscle. Eur J Inflamm. 2014;12 (1):41-52. doi:10.1177/1721727X1401200105
70. Cantón I, Mckean R, Charnley M, Blackwood KA, Fiorica C, Ryan AJ, MacNeil S. Development of an Ibuprofen-releasing biodegradable PLA/PGA electrospun scaffold for tissue regeneration. Biotechnol Bioeng. 2010 Feb 1;105(2):396-408. doi: 10.1002/bit.22530. PMID: 19731254.
71. Tungprapa S, Jangchud I, Supaphol P. Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats. Polym. 2007;48 (17):5030-5041.
72. Jiang H, Fang D, Hsiao B, Chu B, Chen W. Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes. J Biomater Sci Polym Ed. 2004;15(3):279-96. doi: 10.1163/156856204322977184. PMID: 15147162.
73. Sequeira RS, Miguel SP, Cabral CSD, Moreira AF, Ferreira P, Correia IJ. Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration. Int J Pharm. 2019;570:118640.
74. Yang Y, Li W, Yu DG, Wang G, Williams GR, Zhang Z. Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning. Carbohydr Polym. 2019 Jan 1;203:228-237. doi: 10.1016/j.carbpol.2018.09.061. Epub 2018 Sep 26. PMID: 30318208.
75. Maslakci NN, Ulusoy S, Uygun E, Çevikbaş H, Oksuz L, Can HK, Uygun Oksuz A. Ibuprofen and acetylsalicylic acid loaded electrospun PVP-dextran nanofiber mats for biomedical applications. Polym Bull. 2017;74 (8):3283-3299.
76. Shalumon KT, Sheu C, Chen CH, Chen SH, Jose G, Kuo CY, et al. Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation. Acta Biomater. 2018 May;72:121-136. doi: 10.1016/j.actbio.2018.03.044. Epub 2018 Apr 5. PMID: 29626695.
77. Hu C, Liu S, Zhang Y, Li B, Yang H, Fan C, et al. Long-term drug release from electrospun fibers for in vivo inflammation prevention in the prevention of peritendinous adhesions. Acta Biomater. 2013 Jul;9(7):7381-8. doi: 10.1016/j.actbio.2013.03.040. Epub 2013 Apr 6. PMID: 23567943.
78. Luraghi A, Peri F, Moroni L. Electrospinning for drug delivery applications: A review. J Control Release. 2021;334:463-84.
79. Sahmani S, Khandan A, Saber-Samandari S, Mohammadi Aghdam M. Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug. Mater Sci Engin: C. 2020;111:110835.
80. Celebioglu A, Uyar T. Fast Dissolving Oral Drug Delivery System Based on Electrospun Nanofibrous Webs of Cyclodextrin/Ibuprofen Inclusion Complex Nanofibers. Mol Pharmaceutics. 2019;16 (10):4387-4398.
81. Immich APS, Arias ML, Carreras N, Boemo RL, Tornero JA. Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen. Mater Sci Engin: C. 2013;33 (7):4002-4008.
82. Celik G, Oksuz AU. Controlled Release of Ibuprofen From Electrospun Biocompatible Nanofibers With In Situ QCM Measurements. J Macromol Sci A. 2015;52 (1):76-83.
Trends in Pharmaceutical Sciences
Volume 7, Issue 3
September 2021
Pages 201-218

Files

Share

How to cite

Statistics